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Method for extracting icariin from epimedium

A technology of icariin and epimedium, which is applied in the field of drug preparation, can solve the problems of discontinuous production, unfavorable industrial production, and reduction of icariin, so as to reduce extraction temperature, reduce continuous heating time, and increase investment The effect of potency

Active Publication Date: 2017-04-26
北京颐方生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method extracts icariin to hydrolyze the glycosides to obtain icariin and reduce the amount of icariin, etc., and it is static and non-continuous production, which is not conducive to industrial production

Method used

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  • Method for extracting icariin from epimedium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A method for extracting icariin from Epimedium, comprising the steps of:

[0049] (1) Epimedium is pulverized into 10-100 mesh powder; Epimedium powder is input in the continuous countercurrent tubular ultrasonic extraction machine with 120Kg / h speed, reversely imports 95% industrial ethanol with 800L / h flow rate, while maintaining ultrasonic extraction Under the conditions of tube temperature 35°C, ultrasonic frequency 22KHz, and ultrasonic power 32KW, extract for 25 minutes; input the extract into the liquid slag squeeze separation device, separate the slag, and press 20Kg / h for separation to obtain the extract; input the extract Concentrate under reduced pressure in a dynamic circulation low-temperature evaporation concentrator, recover the organic solvent, collect the extract, and obtain Epimedium extract;

[0050] (2) The Epimedium extract of step (1) is dissolved in water, then extracted 2 times with ethyl acetate, each time the organic solvent consumption is 1 / 3 ...

Embodiment 2

[0056] A method for extracting icariin from Epimedium, comprising the steps of:

[0057] (1) Epimedium is pulverized into 10-100 mesh powder; Epimedium powder is input in the continuous countercurrent tubular ultrasonic extraction machine with 120Kg / h speed, reversely imports 95% industrial ethanol with 900L / h flow rate, while maintaining ultrasonic extraction Under the conditions of tube temperature 42°C, ultrasonic frequency 24KHz, and ultrasonic power 32KW, extract for 30 minutes; input the extract into the liquid slag squeeze separation device, separate the slag, and press 60Kg / h for separation to obtain the extract; input the extract Concentrate under reduced pressure in a dynamic circulation low-temperature evaporation concentrator, recover the organic solvent, collect the extract, and obtain Epimedium extract;

[0058] (2) Dissolving the Epimedium extract of step (1) in water, then extracting 3 times with chloroform, each organic solvent consumption is 20% of the water ...

Embodiment 3

[0064] A method for extracting icariin from Epimedium, comprising the steps of:

[0065] (1) Epimedium is crushed into 10-100 mesh powder; Epimedium powder is input in the continuous countercurrent tubular ultrasonic extraction machine with 120Kg / h speed, reversely imports 95% industrial ethanol with 1000L / h flow rate, while maintaining ultrasonic extraction Under the conditions of tube temperature 50°C, ultrasonic frequency 27KHz, and ultrasonic power 32KW, extract for 40 minutes; input the extract into the liquid slag squeeze separation device, separate the slag, and press 100Kg / h for separation to obtain the extract; input the extract Concentrate under reduced pressure in a dynamic circulation low-temperature evaporation concentrator, recover the organic solvent, collect the extract, and obtain Epimedium extract;

[0066] (2) the Epimedium extract of step (1) is dissolved in water, then extracted 3 times with chloroform, each organic solvent consumption is equal to the volu...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine extraction and in particular relates to a method for extracting icariin from epimedium. The method comprises the following steps: extracting an epimedium medicinal material by adopting a continuous countercurrent ultrasonic method, concentrating the obtained extracting solution, dissolving in water, extracting with ethyl acetate and n-butanol successively, taking an n-butanol extraction portion, concentrating, then passing through a macroporous adsorption column, and finally recrystallizing, so that the icariin product is obtained, and detection shows that the purity of the icariin product obtained by adopting the method provided by the invention is more than 98%. The method provided by the invention can be used for extracting the icariin from the epimedium rapidly and efficiently in a large scale; and the production cycle for producing the product is short, the energy consumption is low, and the environmental pollution is less.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and relates to a method for extracting medicinal materials, in particular to a method for extracting icariin from epimedium. Background technique [0002] Epimedium is a traditional Chinese herbal medicine plant resource in my country, with a wide variety and rich reserves. According to the pharmacological effects and medical uses of icariin, especially its hydrolyzed icariin and its corresponding derivatives, Epimedium is rapidly and efficiently extracted from Epimedium plants on a large scale in industry Horoside compounds became a demand. Epimedium contains a variety of active ingredients, icariin (ICA) and flavonoids are the main active ingredients, in addition to alkaloids, lignans, polysaccharides and trace elements, phenolic glycosides, organic acids, ionone class and phenylethanol glycosides etc. The whole herb of Epimedium is used medicinally. Indications for impotence and prematu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
CPCC07H1/08C07H17/07
Inventor 石清东陈赫岩王姣
Owner 北京颐方生物科技有限公司
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