Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of degradable polymer coronary stent and preparation method thereof

A vascular stent and polymer technology are applied in the field of degradable polymer coronary vascular stents and their preparation, which can solve the problems of immaturity, poor effect, and inability to better and convenient use of degradable vascular stents, and reduce the number of vascular stents. The use of drugs, the avoidance of the number of operations, and the effect of good results

Active Publication Date: 2019-11-08
NANJING FIRST HOSPITAL
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] With the continuous progress and development of medical technology, implantable medical devices are getting more and more attention and are widely used. When performing related medical operations on coronary vessels, vascular stents are needed to support the catheter. Stents While satisfying the rigidity of use, it is also necessary to achieve the purpose of being absorbed and degraded by the body, so that it is more convenient for patients to use and reduce the medical expenses and pain of patients. The degradable vascular stent technology under the existing technology is relatively immature and cannot Better Ease of Use, Less Effective

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The present invention provides a technical solution: a degradable polymer coronary stent, comprising: a magnesium alloy, a composite layer, a degradable polyester polymer and starch, wherein the magnesium alloy includes (by mass percentage): zinc 16%, silicon 0.4%, calcium 1.3%, trace elements 2.4%, magnesium 79.9%, the composite layer includes (by mass percentage): reinforcing fiber 14%, tricalcium phosphate 17%, agar 67.5%, water 1.5%.

[0024] Trace elements are composed of one or more of silicon, yttrium, manganese, aluminum, copper, and the degradable polyester polymers are polyglycolic acid, polycaprolactone, polyethylene adipate and polylactic acid-ethanol Acid copolymer, reinforcement fiber is degradable short fiber.

[0025] A method for preparing a degradable polymer coronary stent, the stent is prepared by the following steps:

[0026] S1: Skeleton production: Using zinc, silicon, calcium, trace elements and magnesium as raw materials, the skeleton and conne...

Embodiment 2

[0033] The present invention provides a technical solution: a degradable polymer coronary stent, comprising: a magnesium alloy, a composite layer, a degradable polyester polymer and starch, wherein the magnesium alloy includes (by mass percentage): zinc 18%, silicon 0.5%, calcium 1.7%, trace elements 3%, magnesium 76.8%, the composite layer includes (by mass percentage): reinforcing fiber 18%, tricalcium phosphate 16%, agar 63%, water 2%.

[0034] Trace elements are composed of one or more of silicon, yttrium, manganese, aluminum, copper, and the degradable polyester polymers are polyglycolic acid, polycaprolactone, polyethylene adipate and polylactic acid-ethanol Acid copolymer, reinforcement fiber is degradable short fiber.

[0035] A method for preparing a degradable polymer coronary stent, the stent is prepared by the following steps:

[0036] S1: Skeleton production: Using zinc, silicon, calcium, trace elements and magnesium as raw materials, the skeleton and connectors ...

Embodiment 3

[0043] The present invention provides a technical solution: a degradable polymer coronary stent, comprising: a magnesium alloy, a composite layer, a degradable polyester polymer and starch, wherein the magnesium alloy includes (by mass percentage): zinc 22%, silicon 0.6%, calcium 1.8%, trace elements 3.6%, magnesium 72%, the composite layer includes (by mass percentage): reinforcing fiber 13%, tricalcium phosphate 18%, agar 68%, water 1%.

[0044] Trace elements are composed of one or more of silicon, yttrium, manganese, aluminum, copper, and the degradable polyester polymers are polyglycolic acid, polycaprolactone, polyethylene adipate and polylactic acid-ethanol Acid copolymer, reinforcement fiber is degradable short fiber.

[0045] A method for preparing a degradable polymer coronary stent, the stent is prepared by the following steps:

[0046] S1: Skeleton production: Using zinc, silicon, calcium, trace elements and magnesium as raw materials, the skeleton and connectors ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention relates to the field of implantable medical apparatuses, and in particular to a degradable high-polymer coronary vascular scaffold, which consists of magnesium alloy, a composite layer, a degradable polyester polymer and starch, wherein the magnesium alloy comprises the following components (in percentage by mass): 15-23% of zinc, 0.3-0.7% of silicon, 1-2% of calcium, 2-3.6% of trace elements and the balance of magnesium; and the composite layer comprises the following components (in percentage by mass): 12-23% of strengthening fibers, 15-21% of tricalcium phosphate, 61-72% of agar and the balance of water. The invention also discloses a manufacturing method of the degradable high-polymer coronary vascular scaffold, wherein the vascular scaffold is manufactured by the following steps: S1, making a skeleton; S2, conducting roughness treatment; S3, making a composite layer; and S4, uniformly smearing the composite layer, which is made in the step S3, on a vascular scaffold main body. The vascular scaffold provided by the invention is simpler and is more scientific and reasonable in formula; pain in patients can be reduced to a great extent, the use of medicines can be relieved and operating times in a later period can be reduced; and the vascular scaffold is conducive to popularization.

Description

technical field [0001] The invention relates to the field of implantable medical devices, in particular to a degradable polymer coronary stent and a preparation method thereof. Background technique [0002] With the continuous progress and development of medical technology, implantable medical devices are getting more and more attention and are widely used. When performing related medical operations on coronary vessels, vascular stents are needed to support the catheter. Stents While satisfying the rigidity of use, it is also necessary to achieve the purpose of being absorbed and degraded by the body, so that it is more convenient for patients to use and reduce the medical expenses and pain of patients. The degradable vascular stent technology under the existing technology is relatively immature and cannot Better for ease of use, less effective. Contents of the invention [0003] The purpose of the present invention is to provide a degradable polymer coronary stent and a ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/02A61L31/14
CPCA61L31/022A61L31/086A61L31/10A61L31/148A61L2300/102A61L2300/112A61L2300/232A61L2300/604A61L2420/04A61L2420/06A61L2420/08C08L3/02C08L5/12C08L67/04
Inventor 张代民
Owner NANJING FIRST HOSPITAL