Preparation method of natural macromolecular hollow microspheres

A technology of natural macromolecules and hollow microspheres is applied in the field of preparation of natural macromolecular hollow microspheres. Simple, easy-to-use effects

Inactive Publication Date: 2017-05-10
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the emulsion method requires a long reaction time in the process of preparing natural polymer microspheres, and the yield is low, the preparation process is complicated, and toxic cross-linking agents are required, which destroys the activity of drugs and molecules therein (Shi , et al., 2014)

Method used

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  • Preparation method of natural macromolecular hollow microspheres
  • Preparation method of natural macromolecular hollow microspheres
  • Preparation method of natural macromolecular hollow microspheres

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Disperse chitin powder in a mixture of 20 wt% KOH, 50 wt% NaOH, and 12 wt% urea, freeze it at -30°C, place it for 12 hours, and then thaw it into a solution at room temperature with a concentration of 0.001 wt %. Put the chitin solution into the syringe, the distance between the needle tip and the receiving device is 3 cm, the voltage between the needle tip and the receiving device is 0Kv, and the driving speed of the pump is 0.1mlh -1 , the coagulation liquid is liquid nitrogen, and the chitin balls are dried in a freeze dryer at -20°C. The freeze-dried microspheres are put into water and rinsed until neutral, and freeze-dried again to obtain neutral chitin hollow microspheres.

Embodiment 2

[0029] Disperse chitin powder in a mixture of 20 wt% KOH, 50 wt% NaOH, and 12 wt% thiourea, freeze it at -30°C, place it for 12 hours, and then thaw it into a solution at room temperature with a concentration of 8 wt%. Put the chitin solution into the syringe, the distance between the needle tip and the receiving device is 3 cm, the voltage between the needle tip and the receiving device is 0Kv, and the driving speed of the pump is 0.1 ml h -1 , the coagulation liquid is liquid nitrogen, and the chitin balls are dried in a freeze dryer at -20°C. The freeze-dried microspheres are put into water and rinsed until neutral, and freeze-dried again to obtain neutral chitin hollow microspheres.

Embodiment 3

[0031] Disperse chitin powder in a mixture of 20 wt% KOH, 20 wt% LiOH, and 12 wt% urea, freeze it at -30°C, place it for 12 hours, and then thaw it into a solution at room temperature with a concentration of 0.001 wt %. Put the chitin solution into the syringe, the distance between the needle tip and the receiving device is 100 cm, the voltage between the needle tip and the receiving device is 0Kv, and the driving speed of the pump is 0.1ml h -1 , the coagulation liquid is liquid nitrogen, and the chitin balls are dried in a freeze dryer at -20°C. The freeze-dried microspheres are put into water and rinsed until neutral, and freeze-dried again to obtain neutral chitin hollow microspheres.

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Abstract

The invention discloses a preparation method of natural macromolecular hollow microspheres. The preparation method comprises the following steps: dissolving natural macromolecules in a mixed solvent of KOH, LiOH, NaOH and urea at a low temperature, and obtaining a chitin, cellulose or chitosan solution by virtue of freezing-thawing circulation; and spraying the chitin solution into liquid nitrogen by virtue of an electrostatic drop method, and obtaining chitin, cellulose and chitosan hollow microspheres with a hollow structure by virtue of freeze drying. According to the preparation method of the invention, the chitin, the cellulose and the chitosan hollow microspheres having good biological compatibility and degradation and having a hollow interior and regular pores on spherical walls can be obtained and have a wide application prospect in various fields such as environmental treatment, tissue engineering, agricultural and biological materials and the like.

Description

technical field [0001] The invention belongs to the field of natural polymer materials, and in particular relates to a preparation method of natural polymer hollow microspheres. Background technique [0002] Hollow microspheres have a large specific surface area and have great application prospects in the fields of controlled drug release, artificial cells, catalysts, microreactors, lithium-ion batteries, and environmental treatment, and have attracted the attention of more and more researchers (Zhou , et al., 2016). Natural polymer hollow microspheres have good biocompatibility, degradability, and non-toxicity, and have been widely used in the fields of biomedicine, tissue engineering, and biotechnology (Yang, et al., 2009). [0003] Chitin, chitosan, and cellulose are widely used natural polymers, based on their superior biological properties, such as biocompatibility, biodegradability and physical properties, such as gel-forming, hydrophilic properties, good Mechanical ...

Claims

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Application Information

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IPC IPC(8): C08J3/12C08L5/08C08L1/02
CPCC08J3/12C08J2301/02C08J2305/08
Inventor 施晓文丁福源钱茜杜予民
Owner WUHAN UNIV
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