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Preparation method of curcumin nanometer emulsion

A technology of nanoemulsion and curcumin, applied in the field of preparation of curcumin nanoemulsion, can solve the problems of curcumin destruction, influence of curcumin application, poor water solubility and oil solubility, etc.

Inactive Publication Date: 2017-05-17
何德海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Experiments have proved that curcumin has health functions of lowering blood fat, anti-tumor, anti-inflammation, promoting choleresis, and anti-oxidation. There are two problems in the promotion of curcumin at present. The first is that curcumin is an alcohol-soluble compound. Water-soluble and oil-soluble are relatively poor, have seriously influenced the application of curcumin in water-soluble products and oil-soluble products; Curcumin and phospholipids are added to the organic solvent, heated to 40-90°C, refluxed for 30-180 minutes, and then the organic solvent is removed by rotary thin film evaporation to obtain the curcumin precursor
This method can be completed due to the need for heating, and heating tends to have a greater destructive effect on curcumin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The preparation method of curcumin nanoemulsion, its formula is expressed as follows by weight percentage:

[0045] Curcumin 10%

[0046] Natural VE 5%

[0047] Glyceryl Caprylate 3%

[0048] Soy Lecithin 7%

[0049] Polyoxyethylated Castor Oil 15%

[0050] Glycerin 5%

[0051] water 55%

[0052] The preparation steps are: in a closed anaerobic state, that is, filling nitrogen or an inert gas in a closed environment. Since the effect is the same, only to ensure a continuous anaerobic state, this embodiment chooses to fill nitrogen. After filling nitrogen The air pressure in the closed environment is slightly greater than the air pressure in the external environment, that is, the standard atmospheric pressure, which can effectively prevent the ingress of external air and oxidize the curcumin. Prepare curcumin, natural VE and glyceryl caprylate according to the above proportions to make a suspension for later use; then mix soybean lecithin, polyoxyethylated castor o...

Embodiment 2

[0054] The preparation method of curcumin nanoemulsion, its formula is expressed as follows by weight percentage:

[0055] Curcumin 12%

[0056] Natural VE 3%

[0057] Glyceryl Caprylate 2%

[0058] Soy Lecithin 8%

[0059] Polyoxyethylated Castor Oil 10%

[0060] Glycerin 5%

[0061] water 60%

[0062] Except that proportioning is different from embodiment 1 in this embodiment, others are all identical with embodiment 1.

Embodiment 3

[0064] The preparation method of curcumin nanoemulsion, its formula is expressed as follows by weight percentage:

[0065] Curcumin 10%

[0066] Natural VE 4%

[0067] Glyceryl Caprylate 1%

[0068] Soy Lecithin 5%

[0069] Polyoxyethylated Castor Oil 12%

[0070] Glycerin 3%

[0071] Water 65%

[0072] Except that proportioning is different from embodiment 1 in this embodiment, others are all identical with embodiment 1.

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Abstract

The invention discloses a preparation method of curcumin nanometer emulsion. The curcumin nanometer emulsion is prepared from the following components in percentage by weight: 10-15% of curcumin, 3-8% of natural VE, 1-3% of caprylic capric triglyceride, 5-10% of granulesten, 10-15% of polyoxyethylenated castor oil, 3-10% of glycerine and the balance of water. The invention also discloses the preparation method of the curcumin nanometer emulsion. As the preparation process is conducted in an oxygen-free condition, oxidization of the curcumin is avoided effectively; as a transient heating means is adopted to heat suspension liquid to 200 DEG C within 5 seconds, damage on the curcumin caused by long temperature rise time during the processing process is avoided; in addition, as the soyabean lecithin is adopted and the caprylic capric triglyceride auxiliarily serves as emulsion stabilizer, emulsification stability is improved.

Description

technical field [0001] The invention relates to the field of preparation of curcumin emulsion, in particular to a preparation method of curcumin nanoemulsion. Background technique [0002] Curcumin is a colored substance extracted from turmeric. It has complex components. The main components are curcumin, demethoxycurcumin, and bisdemethoxycurcumin. It is a rare pigment with diketones in the plant kingdom. Diketones. Curcumin is an orange-yellow crystalline powder with a slightly bitter taste and is insoluble in water. In food production, it is mainly used for the coloring of candy, jelly, batter and other products. Experiments have proved that curcumin has health functions of lowering blood fat, anti-tumor, anti-inflammation, promoting choleresis, and anti-oxidation. There are two problems in the promotion of curcumin at present. The first is that curcumin is an alcohol-soluble compound. Water-soluble and oil-soluble are relatively poor, have seriously influenced the app...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/12A61K47/24A61K47/14A61P3/06A61P35/00A61P29/00A61P1/16A61P39/06
CPCA61K47/14A61K47/24A61K9/1075A61K31/12
Inventor 何德海
Owner 何德海
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