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Expanded polytetrafluoroethylene artificial dura mater and preparation technique thereof

A technology of polytetrafluoroethylene and artificial dura mater, which is applied in prosthesis, medical science, etc., can solve the problems of thin thickness and poor anti-sticking performance, and achieve the effects of simple process, convenient operation, reduced volume and manufacturing cost

Inactive Publication Date: 2017-05-17
DABO MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The purpose of the present invention is to overcome the defects of existing artificial dura mater antibacterial, poor anti-adhesive performance and thinner thickness

Method used

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  • Expanded polytetrafluoroethylene artificial dura mater and preparation technique thereof
  • Expanded polytetrafluoroethylene artificial dura mater and preparation technique thereof
  • Expanded polytetrafluoroethylene artificial dura mater and preparation technique thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] S1, mixing materials: the polytetrafluoroethylene of 70% Teflon 601A brand and the isoparaffin solvent oil Isopar-L of 30% mass fraction are mixed uniformly by mass fraction;

[0049] S2, aging: aging the mixture obtained in step S1 at 50°C for 12h;

[0050] S3. Paste extrusion: send the product in the step S2 to an extruder for extrusion, the compression ratio during extrusion is 30, the extrusion temperature is 50°C, and the extrusion pressure is 3Mpa;

[0051] S4. Calendering: send the product in the step S3 to a calender for calendering to obtain a polytetrafluoroethylene base tape. The thickness of the polytetrafluoroethylene base tape is 1.2 mm and the width is 12 cm. During the calendering process, the calendering The speed of the two rollers of the machine is 3m / min;

[0052] S5. Degreasing: degreasing the polytetrafluoroethylene tape obtained in step S4 at 220° C.;

[0053] S6, longitudinal stretching: the product of the step S5 is subjected to longitudinal s...

Embodiment 2

[0057] The invention provides an expanded polytetrafluoroethylene artificial dura mater. The dura mater is prepared by mixing polytetrafluoroethylene whose raw material brand is Daikin F106 and isoparaffin solvent oil Isopar-C.

[0058] The present invention also provides a preparation process of expanded polytetrafluoroethylene artificial dura mater, comprising the following steps,

[0059] S1, mixing materials: the Daikin F106 brand polytetrafluoroethylene with a mass fraction of 75% and the Isopar-C with a mass fraction of 25% are mixed evenly;

[0060] S2, aging: aging the mixture obtained in step S1 at 35°C for 12h;

[0061] S3. Paste extrusion: send the product in step S2 to an extruder for extrusion, the compression ratio during extrusion is 50, the extrusion temperature is 50°C, and the extrusion pressure is 4 Mpa;

[0062] S4, calendering: Send the product in the step S3 to a calender for calendering to obtain a polytetrafluoroethylene base tape, the thickness of the...

Embodiment 3

[0068] The invention provides an expanded polytetrafluoroethylene artificial dura mater. The dura mater is prepared by mixing polytetrafluoroethylene whose raw material brand is Daikin F106 and isoparaffin solvent oil Isopar-C.

[0069] The present invention also provides a preparation process of expanded polytetrafluoroethylene artificial dura mater, comprising the following steps,

[0070] S1, mixing materials: the Daikin F104 brand polytetrafluoroethylene with a mass fraction of 74% and the Isopar-L with a mass fraction of 26% are mixed evenly;

[0071] S2. Aging: aging the mixture obtained in step S1 at 30° C. for 24 hours;

[0072] S3, Paste extrusion: Send the product in the step S2 to an extruder for extrusion, the compression ratio during extrusion is 40, the extrusion temperature is 40°C, and the extrusion pressure is 1 Mpa;

[0073] S4, calendering: Send the product in the step S3 to a calender for calendering to obtain a polytetrafluoroethylene base tape, the thick...

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Abstract

The invention discloses an expanded polytetrafluoroethylene artificial dura mater. The dura mater is prepared by mixing polytetrafluoroethylene and an extrusion aid. The thickness of the dura mater is 0.25-1mm, and the pore size is 0.1-1 mu m. The invention also discloses a preparation technique of the expanded polytetrafluoroethylene artificial dura mater. The preparation technique comprises the following steps: mixing, aging, paste extrusion, calendering, degreasing, longitudinal stretching, lateral stretching and sintering. By adopting the special extrusion technique and special two-way stretching technique, the microscopic sizes of the nodes and fibers are controlled to be less than the diameter or width of bacteria, so that the prepared expanded polytetrafluoroethylene artificial dura mater has the characteristics of favorable antibacterial property and antisticking property. Besides, in order to resist the intracranial pressure, the expanded polytetrafluoroethylene artificial dura mater disclosed by the invention also has the characteristic of super high thickness.

Description

technical field [0001] The invention relates to the technical field of implanted medical device products, in particular to an expanded polytetrafluoroethylene artificial dura mater and a preparation process thereof. Background technique [0002] The dura mater is a tough outer layer of fibrous tissue that covers the brain and neck. On the one hand, it protects and insulates the nervous tissue, and on the other hand, it acts as an impermeable membrane that contains the cerebrospinal fluid. When the dura mater needs to be removed during external trauma or surgery, it is very necessary to repair and reconstruct it. At present, many materials are used as dura mater repair and reconstruction patches, such as patient's own tissue or animal tissue and different kinds of synthetic materials. [0003] As a substitute for dura mater repair or reconstruction, it must have the following characteristics: non-toxic, good biocompatibility, no immunity to the human body, no foreign body r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/56
CPCA61L27/16A61L27/56C08L27/18
Inventor 魏太演曾达林意华林丽明冯柏瀚
Owner DABO MEDICAL TECH CO LTD
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