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A kind of preparation method of nano-microspheres of pH response sustained-release vancomycin

A technology of vancomycin and nano-microspheres, which is applied in the field of material science and nano-materials, and achieves the effects of less investment in equipment, simple and easy preparation methods, and less resource consumption

Active Publication Date: 2019-04-30
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, how to control the release of antibacterial drugs is a relatively big challenge at present.

Method used

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  • A kind of preparation method of nano-microspheres of pH response sustained-release vancomycin
  • A kind of preparation method of nano-microspheres of pH response sustained-release vancomycin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A preparation method of pH-responsive sustained-release vancomycin nano-microspheres, characterized in that it comprises the following steps:

[0035] step one,

[0036] Dissolve 0.15 mmol of template molecule vancomycin, 1 mmol of hydroxyethyl methacrylate and 1 mmol of diethylaminoethyl methacrylate in 10 mL of deionized water and stir to obtain a mixed solution, and then add the cross-linking agent dimethyl Ethylene glycol dimethacrylate and photoinitiator Irgacure 651 were dissolved in 30mL of ethanol and dropped into the mixed solution under stirring state, and the reaction mixture was obtained after stirring for 15min; the crosslinking agent ethylene glycol dimethacrylate The consumption of described photoinitiator Irgacure 651 is the consumption of described vancomycin, hydroxyethyl methacrylate, diethylaminoethyl methacrylate and crosslinking agent ethylene glycol dimethacrylate quality 2% of the sum;

[0037] step two,

[0038] Pour the reaction mixture desc...

Embodiment 2

[0041] A preparation method of pH-responsive sustained-release vancomycin nano-microspheres, characterized in that it comprises the following steps:

[0042] step one,

[0043] Dissolve 0.1 mmol of template molecule vancomycin, 0.5 mmol of hydroxyethyl methacrylate and 0.5 mmol of diethylaminoethyl methacrylate in 5 mL of deionized water and stir to obtain a mixed solution, and then add the crosslinking agent Ethylene glycol dimethacrylate and photoinitiator Irgacure 651 are dissolved in 20mL of ethanol and then dropped into the mixed solution under stirring state, and the reaction mixture is obtained after stirring for 10min; the crosslinking agent ethylene glycol dimethacrylate The consumption of alcohol ester is 10mmol; The consumption of described photoinitiator Irgacure 651 is described vancomycin, hydroxyethyl methacrylate, diethylamino ethyl methacrylate and cross-linking agent ethylene glycol dimethacrylate 1% of the sum of ester mass;

[0044] step two,

[0045] Po...

Embodiment 3

[0048] A preparation method of pH-responsive sustained-release vancomycin nano-microspheres, characterized in that it comprises the following steps:

[0049] step one,

[0050] Dissolve 0.2mmol of template molecule vancomycin, 1.5mmol of hydroxyethyl methacrylate and 1.5mmol of diethylaminoethyl methacrylate in 15mL of deionized water and stir to obtain a mixed solution, and then add the cross-linking agent Ethylene glycol dimethacrylate and photoinitiator Irgacure 651 were dissolved in 40mL of ethanol and then dropped into the mixed solution in the stirring state, and the reaction mixture was obtained after stirring for 20min; the crosslinking agent ethylene glycol dimethacrylate The consumption of alcohol ester is 30mmol; The consumption of described photoinitiator Irgacure 651 is described vancomycin, hydroxyethyl methacrylate, diethylamino ethyl methacrylate and cross-linking agent ethylene glycol dimethacrylate 3% of the sum of ester masses;

[0051] step two,

[0052]...

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Abstract

The invention discloses a preparation method for a nanoparticle capable of releasing vancomycin by responding to pH. The method comprises the following steps of: dissolving template molecule vancomycin, functional monomer hydroxyethyl methylacrylate and 2-(diethylamino) ethyl methacrylate in deionized water and uniformly stirring, thereby acquiring a mixed solution; dissolving a cross-linking agent and a photoinitiator in ethyl alcohol and then dripping into the mixed solution under a stirring state, and then acquiring the reaction mixture after stirring; pouring the reaction mixture into a three-neck flask and standing by for 1-3h at 4 DEG C; introducing nitrogen into the flask so as to discharge air in the flask; putting the flask to an environment at 15-35 DEG C, performing UV-irradiation in the wavelength of 365nm on the flask and continuously mechanical stirring for 0.5-1.5h, thereby acquiring the nanoparticle carrying the vancomycin. The preparation method disclosed by the invention is simple and easy; the resource consumption is less; a method for triggering precipitation polymerization by ultraviolet rays is economic and environment-friendly; the vancomycin is prevented from thermal decomposition under high temperature; the prepared nanoparticle is high in drug loading capacity; the release of the vancomycin can be effectively controlled.

Description

technical field [0001] The invention relates to the technical fields of material science and nanomaterials, in particular to a method for preparing pH-responsive sustained-release vancomycin nano-microspheres. Background technique [0002] Biomedical materials are the basis for the study of artificial organs and medical devices, and are used for diagnosing, treating diseases, surgically repairing or replacing damaged tissues and organs, or enhancing their functions without adversely affecting the organism. . Among them, biomedical implant materials have received extensive attention from researchers in recent years. [0003] Surgical implants are often used to restore joint function in patients. At present, the problem of infection caused by tissue rejection at the implant site greatly limits the widespread use of implant materials. This kind of infection usually leads to the failure of the implant operation. At this time, the general measure is to take out the implant and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F222/14C08F220/18C08F220/28C08F220/34C08F2/48C08F2/44A61K9/51A61K47/32A61K38/14A61P31/04
CPCA61K9/0002A61K9/5138A61K38/14C08F2/44C08F2/48C08F220/18C08F220/1804C08F222/1006C08F222/102C08F220/281C08F220/34
Inventor 吴水林毛丛杨刘想梅谢显洲谭磊许子强
Owner HUBEI UNIV
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