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Composition for preventing and treating radiation-induced oral mucositis and application of composition

A technology of oral mucositis and composition, which is applied in the field of medicine, can solve problems such as ineffective mucosal repair, decreased body immunity, and influence on wound healing, achieving no dependence on use, promoting regeneration and repair, shortening the The effect of wound healing time

Inactive Publication Date: 2017-05-24
BENGT I SAMUELSSON INST OF LIFE SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For radiation-induced oral mucositis, local anti-inflammatory, bactericidal and analgesic agents are often used to treat and relieve clinically, but simple anti-bacterial and anti-inflammatory agents do not have a positive effect on the repair of the mucosa, and radiation causes the body’s immunity to decrease, often due to the combination of other infections Aggravate symptoms and affect wound healing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1: A preparation method of mussel soft tissue extract.

[0044] Shell the mussels, collect 300g of soft tissue, divide it into three parts, add 100ml of the acidic solution in the table below with a content of 0.3%, homogenate for 10 minutes, and centrifuge to obtain the supernatant, which is the mussel soft tissue extract.

[0045] The protein content and pH value in the supernatant were determined, and the protein content was determined by the Coomassie brilliant blue method.

[0046] Table 1

[0047] example acid solution protein content pH value 1 citric acid 2.6mg / ml 4.5 2 Acetic acid 3.5mg / ml 3.2 3 perchloric acid 3.0mg / ml 1.0

Embodiment 2

[0048] Embodiment 2: A kind of composition of preventing and treating radiation oral mucositis

[0049] The composition for preventing and treating radioactive oral mucositis comprising mussel soft tissue extract and fungal polysaccharide is composed of the following components: 15 mg dry powder of mussel soft tissue extract, 20 mg dry powder of fungal polysaccharide, 1 mg molasses, and 0.05 mg menthol. Make a mouthwash after fully dissolving in water.

[0050] Collect 20 patients who need face and neck radiotherapy, and randomly divide them into a test group and a control group. The test group uses the mouthwash for preventing and treating oral mucositis prepared in Example 2 for gargling 30 minutes before radiotherapy, and the control group performs blank control. After radiotherapy, the occurrence of oral mucositis in each subject was observed.

[0051] Evaluation of radiation oral mucositis according to WHO mucosal reaction: Grade I-no response or mucosal hyperemia; Grade...

Embodiment 3

[0054] Embodiment 3: A kind of composition of preventing and treating radiation oral mucositis

[0055] The composition for preventing and treating radioactive oral mucositis comprising mussel soft tissue extract and fungal polysaccharide consists of the following components: dry powder of mussel soft tissue extract 13.5 mg, dry powder of fungal polysaccharide 16 mg, peppermint oil 0.01 mg, and the above substances are fully dissolved in physiological saline Made into a spray.

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PUM

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Abstract

The invention belongs to the field of medical treatment and particularly relates to composition for preventing and treating radiation-induced oral mucositis and an application of the composition. The composition contains mytilus edulis linnaeus soft tissue extract and fungal polysaccharide. The composition for preventing and treating radiation-induced oral mucositis can block radiation injury caused by extrinsic factors, has ultrastrong radiation-proof effect, promotes tissue regeneration and repair of oral mucosa while preventing oral mucositis, shortens wound healing time and has functions of diminishing inflammation and relieving pain. The composition is mild and non-irritating, has no toxic or side effects and avoids usage dependency.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a composition for preventing and treating radiation-induced oral mucositis and its application. Background technique [0002] In the medical field, radiological diagnosis and treatment are widely used, especially clinical radiotherapy for tumor patients has become a common method of tumor treatment, which increases the probability of medical staff and patients being exposed to radiation. Exposure to direct or indirect ionizing radiation for a long time will seriously damage the body function of the whole body, leading to a serious decline in the body's immunity and defense repair function. Radiation oral mucositis is one of the common serious complications in the process of radiotherapy for head and neck tumors. Initially, the oral mucosa is red and swollen, followed by reactive expansion of capillaries, local congestion, erythema, erosion, ulcers, and pseudomembrane coverage....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/618A61P1/02A61P39/00A61P29/00A61K31/715
CPCA61K35/618A61K31/715
Inventor 高敏
Owner BENGT I SAMUELSSON INST OF LIFE SCI CO LTD