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In-situ gel preparation and use thereof

An in-situ gel and preparation technology, applied in aerosol delivery, medical preparations of non-active ingredients, extracellular fluid diseases, etc., can solve problems affecting drug absorption and curative effect, shortening the contact time between drugs and nasal cavity surfaces, etc. , to achieve the effect of no nasal cilia toxicity, good compliance and strong affinity

Pending Publication Date: 2017-05-31
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The nasal mucosa is sensitive to external stimuli, and the cilia on the surface drive the secretion to the pharynx at a rate of 5-6mm / min. Generally, the residence time of liquid drugs in the nasal cavity is only 10-20min, which is easily eliminated, thus greatly shortening the The contact time between the drug and the surface of the nasal cavity directly affects the absorption and efficacy of the drug

Method used

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  • In-situ gel preparation and use thereof
  • In-situ gel preparation and use thereof
  • In-situ gel preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Preparation formula and preparation method:

[0012]

[0013] Preparation method: Weigh the prescription amount of Poloxamer 188 and hydroxypropylmethylcellulose K4M, add 600mL of deionized water, heat in a water bath at 90°C to completely dissolve the material aqueous solution into an environmentally sensitive hydrophilic gel, and then add the prescription The amount of polyethylene glycol 600, glucose, and Bropol to dissolve and mix well, add deionized water to the total amount, and divide into nasal drops or nasal spray bottles with spray pumps to obtain the product.

Embodiment 2

[0015] Preparation formula and preparation method:

[0016]

[0017]

[0018] Preparation method: Weigh the prescribed amount of deacetylated gellan gum and Carbomer 910, add 800mL of deionized water, heat in a 90°C water bath to completely dissolve the material aqueous solution into an environmentally sensitive hydrophilic gel, and then add the prescribed amount of Dissolve hyaluronic acid, glucose, and chlorhexidine acetate, mix well, add deionized water to the total amount, and divide into nasal drops or nasal spray bottles with a spray pump to obtain the product.

Embodiment 3

[0020] Preparation formula and preparation method:

[0021]

[0022] Preparation method: Weigh the prescribed amount of Poloxamer 407 and Carbomer 940, add 650mL of deionized water to shake and mix, refrigerate in a refrigerator at 4°C overnight to fully swell to form a uniform and clear gel solution, and then add Prescribed amount of polyethylene glycol 200, mannitol, benzalkonium bromide, benzoic acid to dissolve and mix thoroughly, add deionized water to the total amount, and divide into nasal drops or nasal spray bottles with spray pumps , that is.

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PUM

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Abstract

The invention relates to a use of an in-situ gel preparation in preparation of an agent for wetting a nasal cavity in a plateau or a dry environment, protecting a nasal cavity in a dry special environment and preventing and treating rhinitis sicca and epistaxis. The in-situ gel preparation comprises, by massic volume, 1-30% of an environment-sensitive hydrophilic gel matrix material, 2.5-25% of other pharmaceutically acceptable pharmaceutical excipients and the balance of water.

Description

technical field [0001] The present invention relates to an in-situ gel preparation and its application. Specifically, the present invention relates to the application of the in-situ gel preparation in the protection of the nasal cavity in a plateau or dry environment, the protection of the nasal cavity in a special dry environment, and the prevention and treatment of rhinitis sicca and epistaxis. Background technique [0002] In situ gel, also known as instant gel, has a large water content and is a new type of drug delivery carrier that is sensitive to environmental factors and has the advantages of both solutions and gels. The in-situ gel preparation is in a liquid state with good fluidity at room temperature, and it is administered in the form of a solution. Due to changes in local temperature, ionic strength or pH, a phase transition occurs instantaneously at the application site to form a semi-solid or solid preparation. [0003] The nasal mucosa is sensitive to externa...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/32A61P11/02A61P7/04
Inventor 高钰琪杨峰余岚徐刚马志强谢和兵李现贵张钢
Owner ARMY MEDICAL UNIV
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