A kind of atomoxetine hydrochloride oral solution and preparation method thereof

A technology of atomoxetine hydrochloride and oral solution, which is applied in the field of atomoxetine hydrochloride oral solution and preparation thereof, can solve the problems of difficult taking by patients, poor taste and the like, achieves high product stability, simple preparation method, and eliminates fear sense of effect
CN106727291BActive Publication Date: 2020-02-11SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
6 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANDONG DYNE MARINE BIOTECHCAL PHARM HLDG CO LTD
Publication Date
2020-02-11

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to pharmaceutical composition containing atomoxetine hydrochloride and a preparation method of the pharmaceutical composition, in particular to an atomoxetine hydrochloride oral solution preparation and a preparation method thereof. Beta-cyclodextrin and tartaric acid are combined for taste masking treatment, the atomoxetine hydrochloride oral solution preparation with good taste is prepared, the preparation method is simple, the atomoxetine hydrochloride oral solution preparation has the good taste, large quantities of sweetening agents, flavors and fragrances are not added, the toxic and side effects are reduced, the defects of poor compliance of existing atomoxetine hydrochloride preparations for children and the like are overcome, the medication compliance of children patients is improved, and the clinical medication requirement of children is met.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a pharmaceutical composition containing atomoxetine hydrochloride and a preparation method thereof, in particular to a atomoxetine hydrochloride oral solution preparation and a preparation method thereof. Background technique

[0002] Atomoxetine hydrochloride: (-)-N-methyl-3-phenyl-3-(2-methylphenoxy)-propylamine hydrochloride, the structural formula is as shown in formula 1:

[0003]

[0004] It is the first non-stimulant drug for the treatment of attention deficit hyperactivity disorder (ADHD). The drug was developed by Lilly Company in the 1980s. It was originally intended to develop the product as an antidepressant, but it was terminated in the Phase III antidepressant trial in the early 1990s, but it failed in attention deficit hyperactivity disorder (attention deficit hyperactivity disorder). Disorder, ADHD) tests have shown effective results, and it was launched in the United States in January 2003. The trade name i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More