Seaweed gum vegetable soft capsule shell and preparation method

A seaweed gel and soft capsule technology, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of capsule shell rupture, high cross-linking degree, amino acid cross-linking reaction, etc., to achieve less pollution, The effect of high chemical stability

Active Publication Date: 2020-03-10
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to its special molecular structure, animal-derived gelatin has many disadvantages in practical application: (1) The water content is too high, and the hygroscopic drug filled is easy to absorb the water in the soft capsule shell, resulting in drug instability and easy rupture of the capsule shell (2) High degree of cross-linking, prone to amino acid cross-linking reaction, resulting in disintegration or reduced dissolution of soft capsules; (3) Gelatin easily reacts with aldehyde-containing pharmaceutical ingredients to produce insoluble substances, which shortens the disintegration time Extension; (4) According to the ethnic habits of Muslims at home and abroad, animal protein capsules are not edible, so the supply of drugs to Islamic countries and regions is restricted, and it has become a product that hinders sales; (5) Gelatin soft capsules may cause animal-origin infections The possibility of disease, especially the frequent occurrence of mad cow disease and foot-and-mouth disease in recent years

Method used

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  • Seaweed gum vegetable soft capsule shell and preparation method
  • Seaweed gum vegetable soft capsule shell and preparation method
  • Seaweed gum vegetable soft capsule shell and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: a kind of vegetable capsule shell of soft capsule, it comprises the raw material of following weight ratio:

[0032] Agar 3Kg, Alginate 4Kg, κ-Carrageenan 10Kg, Sorbitol 25Kg, Glycerin 15Kg, CaCl 2 0.02Kg, water 43Kg.

[0033] Vegetable capsule shells can be prepared by the existing soft capsule production method. The compressed capsules are sent to a drying room for drying, the drying temperature is set at 40° C., the relative air humidity is controlled at 30%, and the drying time is about 3 hours.

[0034] Evaluate the rubber elasticity, strength and bonding temperature of the product of Example 1, and measure the appearance properties, moisture content, disintegration time limit and other indicators for the soft capsule samples produced in a small trial.

[0035] The results are shown in Table 1:

[0036] The capsule shell property of table 1 embodiment 1

[0037]

Embodiment 2

[0038] Embodiment 2: a kind of vegetable capsule shell of soft capsule, it comprises the raw material of following weight ratio:

[0039] Agar 2Kg, Alginate 8Kg, κ-Carrageenan 8Kg, Sorbitol 30Kg, Glycerin 10Kg, ZnCl 2 0.03Kg, water 42Kg.

[0040] Vegetable capsule shells can be prepared by the existing soft capsule production method. The compressed capsules are sent to a drying room for drying, the drying temperature is set at 42° C., the relative air humidity is controlled at 35%, and the drying time is about 3 hours.

[0041] Evaluate the rubber elasticity, strength and bonding temperature of the product of Example 2, and carry out the measurement of indicators such as appearance properties and moisture content to the soft capsule sample produced in a small trial.

[0042] The results are shown in Table 2:

[0043] The capsule shell property of table 2 embodiment 2

[0044]

Embodiment 3

[0045] Embodiment 3: a kind of vegetable capsule shell of soft capsule, it comprises the raw material of following weight ratio:

[0046] Agar 4Kg, Alginate 6Kg, κ-Carrageenan 6Kg, Sorbitol 22Kg, Glycerin 18Kg, ZnCl 2 0.02Kg, water 44Kg.

[0047] Vegetable capsule shells can be prepared by the existing soft capsule production method. The compressed capsules are sent to a drying room for drying, the drying temperature is set at 45° C., the relative air humidity is controlled at 40%, and the drying time is about 2 hours.

[0048] Evaluate the rubber elasticity, strength and bonding temperature of the product of Example 3, and measure the appearance properties, moisture content, disintegration time limit and other indicators for the soft capsule samples produced in a small trial.

[0049] The results are shown in Table 3:

[0050] The capsule shell property of table 3 embodiment 3

[0051]

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Abstract

The invention relates to formulae and properties of seaweed gel plant soft capsule shells. The formula of the seaweed gel plant soft capsule shell comprises 10-30 parts by weight of a seaweed gel, 30-50 parts by weight of a plasticizer, 0.001-0.1 part by weight of a coagulant aid and the balance of water, wherein the water content accounts for 10-20% of the total weight of the capsule shell. The seaweed gel plant soft capsule shell provided by the invention has the characteristics of being colorless and transparent, high in elasticity, high in strength, low in bonding temperature and the like.

Description

technical field [0001] The invention relates to the technical field of soft capsules, in particular to the formula and properties of vegetable soft capsule shells with alginate as the main raw material. Background technique [0002] Soft capsule refers to a dosage form made by sealing a certain amount of oily liquid medicine or semi-solid contents such as suspensions and emulsions in spherical or oval soft capsules. It has been widely used in health care products and Preparation of medicines. Compared with other solid dosage forms, soft capsules have the advantages of high bioavailability, good sealing performance, beautiful appearance, and suitable for multiple purposes. In recent years, due to its unique properties and efficacy, soft capsules have been paid more and more attention by the medical and health circles, and their applications have become more and more extensive. At present, the medicines and health foods of soft capsule preparations at home and abroad, the va...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/26A61K47/10A61K47/02
CPCA61K9/4816A61K47/02A61K47/10A61K47/26A61K47/36
Inventor 史大永李祥乾王立军江波吴宁
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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