Method for producing cordyceps sinensis Qisheng capsule preparation
A production method and technology of Cordyceps, which are applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve the problems of easy rejection, single production method, loss of active ingredients, etc., and achieve a simple and feasible production method. The effect of reducing energy consumption and avoiding the loss of ingredients
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[0020] Example 1
[0021] The production method of Cordyceps Qishen capsules includes the following steps:
[0022] 1) Weigh the raw materials according to the weight portion for use: 80g Cordyceps, 1200g Astragalus, 600g Salvia, 600g Safflower, 320g Suanzaoren;
[0023] 2) Take the Cordyceps sinensis and crush it into fine powder;
[0024] 3) Take the astragalus, crush it, pass a 100-mesh sieve, place it in a container, add double weight of 85% (v / v) ethanol, stir and extract at 300rpm, control the microwave power to 500W during the extraction process, and the extraction time to 120min; Then place it at 4°C for 8 hours, filter, and filter the residue for use; the filtrate is evaporated under reduced pressure to recover ethanol, and the filtrate is concentrated to extract A with a density of 1.2g / ml; the content of astragaloside IV in extract A is tested by high performance liquid chromatography 1.31mg / ml;
[0025] Add twice the weight of the filter residue to the above filter residue...
Example Embodiment
[0039] Example 2
[0040] Animal toxicity test
[0041] There were 40 healthy Kunming mice, half male and half male, and weighed 18.6±2.1g. The 40 mice were randomly divided into two groups, each group was half male and half male, and 20 of them served as a control group and were irrigated with normal water; Mice were given the preparation of Example 1 at a dose of 200 mg / kg three times a day. Toxicity experiments on mice showed that: Compared with the control group, there was no significant difference in mice after administration. The experiment was observed for two consecutive weeks. The general condition, food intake, drinking water, and weight gain were normal. On the day of administration and within two weeks after administration, no animal deaths were seen, indicating that the drug has low toxicity and is safe for clinical use.
Example Embodiment
[0042] Example 3
[0043] Comparison test of efficacy
[0044] Animals: 80 SD male rats, weighing 219±13g, healthy and clean, raised in the company's experimental animal center.
[0045] Grouping treatment: 80 SD male rats were randomly selected as the blank control group based on no significant difference in body weight, and the remaining 60 rats were prepared for adriamycin nephropathy model. The model rats were randomly divided into model control group (gavage of normal saline, dose 100mg / kg), Example 1 group (gavage of the preparation produced in Example 1, dose 100mg / kg), control group 1 (gavage control The preparation produced in Example 1, with a dose of 100 mg / kg), with 20 animals per group. Gavage once a day for one month. Rats in each group were left with 24h urine volume at the beginning and end of the experiment to measure the quantification of 24h urine protein (Sullic acid method).
[0046] Observation indicators: including the rat's diet, body hair, stool, mental sta...
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