Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for producing cordyceps sinensis Qisheng capsule preparation

A production method and technology of Cordyceps, which are applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve the problems of easy rejection, single production method, loss of active ingredients, etc., and achieve a simple and feasible production method. The effect of reducing energy consumption and avoiding the loss of ingredients

Active Publication Date: 2017-05-31
XIANGYU PHARMA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant found in the pharmaceutical process that the production method of the drug is relatively simple, and the same extraction process is used for various raw materials, so there is a defect in the loss of active ingredients, and the Cordyceps Qishen Capsules need to be taken 4 capsules each time, three times a day, and the dosage is too large , some patients find it hard to accept and prone to rejection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The production method of Cordyceps Qishen Capsules, it comprises the steps:

[0022] 1) Weigh each raw material according to the weight part for later use: Cordyceps sinensis 80g, astragalus 1200g, salvia miltiorrhiza 600g, safflower 600g, jujube seed 320g;

[0023] 2) Take Cordyceps sinensis and crush it into fine powder;

[0024] 3) Take astragalus, crush it, pass through a 100-mesh sieve, put it in a container, add twice the weight of 85% (v / v) ethanol, stir and extract at 300rpm, control the microwave power to 500W during the extraction process, and the extraction time is 120min; Then place it at 4°C for 8 hours, filter, and filter the residue for later use; the filtrate is evaporated under reduced pressure to recover ethanol, and the filtrate is concentrated to extract A with a density of 1.2g / ml; the content of astragaloside IV in the extract A is tested by high performance liquid chromatography 1.31mg / ml;

[0025] Add twice the weight of water to the above filt...

Embodiment 2

[0040] Animal Toxicity Test

[0041] 40 healthy Kunming strain mice, half male and half female, body weight 18.6±2.1g, 40 mice were randomly divided into two groups, with half male and half male in each group, 20 of which were used as the control group and fed with normal water; the other 20 Only mouse is given the preparation of embodiment 1, dosage is 200mg / kg, every day three times, application mouse is carried out toxicity experiment and shows: compare with control group, after administration, mouse does not see obvious difference, and experiment observes continuously for two weeks, and mouse General condition, food intake, drinking water, and weight gain were all normal. On the day of administration and within two weeks after administration, no animal died, suggesting that the drug has low toxicity and is safe for clinical use.

Embodiment 3

[0043] Drug efficacy comparison test

[0044] Animals: 80 SD male rats, weighing 219±13g, healthy and clean, raised in the experimental animal center of our company.

[0045] Grouping treatment: 80 SD male rats, 20 were randomly selected as blank control group according to no significant difference in body weight, and the remaining 60 were prepared for doxorubicin nephropathy model. The model rats were randomly divided into model control group (gastric administration of normal saline, dose 100 mg / kg), Example 1 group (gastric administration of the preparation produced in Example 1, dose 100 mg / kg), control group 1 (gastric administration of control The preparation produced in Example 1, dose 100mg / kg), 20 rats in each group. Gastrointestinal administration once a day for one month in a row. The rats in each group were collected 24h urine volume at the beginning and end of the experiment to measure the 24h urine protein (sulfallic acid method).

[0046] Observation indicator...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Uv intensityaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of Chinese medicinal herb extraction and discloses a method for producing a cordyceps sinensis Qisheng capsule preparation. The method comprises the following steps: 1) weighing raw materials; 2) preparing cordyceps sinensis fine powder; 3) preparing astragalus extract; 4) preparing radix salviae milliorrhizae extract; 5) preparing safflower extract; 6) preparing spine date seed extract; and 7) uniformly mixing, grinding and granulating. The preparation produced by the invention has an excellent effect of treating chronic nephritis, and the effect is superior to that of the existing cordyceps sinensis Qisheng capsule product.

Description

technical field [0001] The invention belongs to the technical field of Chinese herbal medicine extraction, and in particular relates to a production method of a capsule preparation of Cordyceps Qishen. Background technique [0002] Cordyceps Qishen Capsule is an effective drug for treating chronic nephritis. Its ingredients are relatively simple, its effect is good, and its side effects are small, so it is favored by patients. The applicant found in the pharmaceutical process that the production method of the drug is relatively simple, and the same extraction process is used for various raw materials, which has the defect of loss of active ingredients, and the Cordyceps Qishen Capsules need to be taken 4 capsules each time, three times a day, and the dosage is too large , some patients are difficult to accept, prone to rejection. How to maximize the utilization of raw materials and improve drug efficacy by improving the process is a problem that we need to study. Contents...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/725A61K9/48A61P13/12
CPCA61K9/48A61K36/068A61K36/286A61K36/481A61K36/537A61K36/725A61K2236/19A61K2236/331A61K2236/333A61K2236/39A61K2236/53A61K2300/00
Inventor 林凡儒聂昌盛付君叶毛传伟杜玲杰
Owner XIANGYU PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com