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Method for improving conception rate of milk cows with ovarian cyst

A technology for ovarian cysts and conception rate, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, peptide/protein components, etc., can solve the problem of difficulty in further improving the conception rate of cows with ovarian cysts, and achieves good application prospects and easy operation. , the effect of reducing costs

Inactive Publication Date: 2017-05-31
BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] PGF2a and GnRH have been used to improve the conception rate of cows with ovarian cysts, and have achieved certain results, but this technology has hit a bottleneck, and it is difficult to further improve the conception rate of cows with ovarian cysts

Method used

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  • Method for improving conception rate of milk cows with ovarian cyst
  • Method for improving conception rate of milk cows with ovarian cyst

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 Diagnosis of Ovarian Cyst in Dairy Cows

[0024] Diagnostic instrument: veterinary B-ultrasound instrument (Honda HS-1500, Japan).

[0025] diagnosis method:

[0026] For long-maturity infertile lactating cows, use the rectum to grasp B-ultrasound diagnosis. The frequency of B-ultrasound diagnosis is 7.5MHz, and the abnormal situation of the ovary can be observed through the display screen.

[0027] diagnostic result:

[0028] Ultrasound shows that the diameter of the ovary is more than 20mm, the follicle wall thickness is less than 3mm, and the follicle structure that can exist for at least 7 days without the presence of active corpus luteum tissue is a follicular cyst; the diameter of the ovary is more than 20mm, the follicle wall thickness is more than 3mm, and the texture is hard The structure of the corpus luteum is a corpus luteum cyst.

Embodiment 2

[0029] Embodiment 2 Improves the method for conception rate of dairy cows with ovarian cysts

[0030] Test cows: 74 cows with ovarian cysts diagnosed in Example 1.

[0031] treatment method:

[0032] Method A:

[0033] a: Intramuscular injection of cloprostenol (PGF2a) 0.6 mg to cows diagnosed with cysts on day 0;

[0034] b: 2 days later, intramuscular injection of gonadotropin-releasing hormone (GnRH) 100 μg;

[0035] c: 6 days later, intramuscular injection of gonadotropin-releasing hormone (GnRH) 100 μg;

[0036] d: After 7 days, intramuscular injection of cloprostenol (PGF2a) 0.6 mg;

[0037] e: 56 hours later, intramuscular injection of gonadotropin-releasing hormone (GnRH) 100 μg;

[0038] f: 16 hours apart, regular insemination.

[0039] Method B:

[0040] a: Intramuscular injection of cloprostenol (PGF2a) 0.6 mg to cows diagnosed with cysts on day 0, and intravenous injection of luteinizing hormone (LH) 200 units;

[0041] b: 2 days later, intramuscular inject...

Embodiment 3

[0053] Example 3 Semen Thawing, Insemination Method and Early Pregnancy Diagnosis

[0054] 1) Take out 0.25mL thin tube frozen semen of dairy cows (purchased from Beijing Dairy Cow Center's sexually controlled frozen semen) from liquid nitrogen, and thaw in a 38°C water bath for 30 seconds;

[0055] 2) Cut off the cap of the thin tube, add frozen semen into the insemination gun, and prepare for insemination;

[0056] 3) Insemination method

[0057] Strictly disinfect the vulva of cows. Deep insemination of the uterine body is used, and the insemination site is required to be 2-5 cm deep in the uterine horn on the ovulation side, so as to ensure that enough sperm reach the site for fertilization with the egg. And do "light insertion, slow push, slow out" during insemination, so as not to cause damage to the cow's uterus.

[0058] 4) Early pregnancy diagnosis

[0059] 28 days after mating, collect 5ml of blood, separate the serum, use the IDEXX Visual Early Pregnancy Detecti...

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Abstract

The invention provides a method for improving the conception rate of milk cows with ovarian cyst. According to the method provided by the invention, the milk cows are treated through an effective amount of rHCG (recombinant Human Chorionic Gonadotropin), PGF2a (cloprostenol) and GnRH (Gonadotropin-releasing Hormone) within schedule time and the conception rate is improved. The invention further provides a medicament combination comprising the rHCG, the PGF2a and the GnRH. A milk cow experiment shows that the method can be used for promoting the normality of a milk cow reproductive cycle, can be widely popularized and applied in the field of livestock breeding and has good market prospect and social effect.

Description

technical field [0001] The invention relates to the technical field of livestock reproductive disorder control, in particular to a method for improving the conception rate of dairy cows with ovarian cysts. Background technique [0002] Ovarian cyst is one of the most common causes of infertility in dairy cows. It directly leads to low reproductive efficiency of dairy cows in breeding production. The incidence of ovarian cysts in dairy cows is as high as 6% to 17%, sometimes even as high as 30%. Ovarian cysts mainly include follicular cysts and corpus luteum cysts. Follicular cysts are mainly formed due to follicular epithelial degeneration, follicular wall connective tissue hyperplasia and thickening, egg cell death, and unabsorbed or increased cell fluid. Follicular cysts mostly occur during the period of the highest milk production in the 4th to 6th parity, and the main features are irregular frequent estrus and continuous estrus, and even euphoria. Luteal cyst is a cys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/24A61P15/08A61K38/09A61K31/5575
CPCA61K38/24A61K9/0019A61K31/5575A61K38/09A61K2300/00
Inventor 白佳桦刘彦许晓玲冯涛肖霖力宋玉清肖银霞
Owner BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
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