Synthesis of amphipathic block antibacterial peptide as well as preparation method and application of assembly of amphipathic block antibacterial peptide

Abstract

The invention provides synthesis of amphipathic block antibacterial peptide as well as a preparation method and application of an assembly of the amphipathic block antibacterial peptide. The amphipathic block antibacterial peptide is prepared from hydrophilic amino acid, hydrophobic amino acid, triphosgene, an organic solvent, an initiator, a de-protection agent and a precipitant. The amphipathic block antibacterial peptide provided by the invention has broad-spectrum and excellent antibacterial properties, is an economic, low-toxic and stable biological material, has wide application prospects and values, is low in raw material price, easy in raw material obtaining and low in cost, and in addition, the synthesis is simple in route and controllable in condition.

Description

technical field

[0001] The invention belongs to the field of antibacterial biomaterials, and in particular relates to the synthesis of an amphiphilic block antibacterial peptide and the preparation method and application of an assembly thereof. Background technique

[0002] At present, the long-term abuse of antibiotics has led to the emergence and widespread spread of super-resistant bacteria, which has reduced the effectiveness of antibiotics, and even some bacteria are difficult to kill by antibiotics, such as bacteria carrying the MCR‐1 gene. Therefore, it is urgent to seek new antibacterial agents to replace traditional antibiotics. Although inorganic antibacterial agents such as Ag and its metal oxides have good antibacterial properties, their biocompatibility limits their wide application in the human body; while organic antibacterial agents such as quaternary ammonium salts, halogenated amines, and biguanides And chitosan, etc., also limit its application because of...

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