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A preparation method of ferric oxide-loaded nano hydrogel based on interpenetrating network structure

An interpenetrating network structure, nano-hydrogel technology, applied in the field of preparation of ferric tetroxide-loaded nano-hydrogel, can solve the problems of limited application, easy aggregation of water phase incompatibility, etc., and achieve good biocompatibility, The effect of easy availability of raw materials and simple process

Active Publication Date: 2019-02-01
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional Fe3O4 magnetic nanoparticles have limited their application in various fields due to their easy aggregation and incompatibility with water. The microspheres are also superparamagnetic, and can eventually be widely used in biological fields such as drug-targeted therapy and magnetic resonance bioimaging.

Method used

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  • A preparation method of ferric oxide-loaded nano hydrogel based on interpenetrating network structure
  • A preparation method of ferric oxide-loaded nano hydrogel based on interpenetrating network structure
  • A preparation method of ferric oxide-loaded nano hydrogel based on interpenetrating network structure

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Take 1.9027g NIPAM, 0.0355g MBA, 0.076g SDS and dissolve in 140ml deionized water, and bubble N at room temperature 2 Deoxygenation, magnetic stirring for 100 minutes; the reaction temperature was raised to 70 ° C, and 2 Keep warm for 30 minutes under protection;

[0033] Then dissolve 0.083g initiator APS in 10ml deionized water, add to the above solution, keep N 2 atmosphere, continue to react for 4 hours; then soak the obtained reactant in deionized water and dialyze for 7 days, change the water three times a day to remove residual reaction raw materials and electrolytes in the reaction system; the molecular weight cut-off of the dialysis bag used is 8000-14000 to obtain PNIPAM.

[0034] Take 15ml PNIPAM solution, dilute ten times, add 0.3203g MBA, N 2 Stir magnetically for 30min under protection; add 1.523g AA under ice bath, and stir magnetically for 20min; then mix 0.1023g APS and 0.1023g Na 2 S 2 o 5 Dissolve in 5ml deionized water respectively, add the abov...

Embodiment 2

[0038] Take 1.9027g NIPAM, 0.0355g MBA, 0.076g SDS and dissolve in 140ml deionized water, and bubble N at room temperature 2 Deoxygenation, magnetic stirring for 100 minutes; the reaction temperature was raised to 70 ° C, and 2 Keep warm for 30 minutes under protection;

[0039] Then dissolve 0.083g initiator APS in 10ml deionized water, add to the above solution, keep N 2 atmosphere, continue to react for 4 hours; then soak the obtained reactant in deionized water and dialyze for 7 days, change the water three times a day to remove residual reaction raw materials and electrolytes in the reaction system. The molecular weight cut-off of the dialysis bag used is 8000-14000. That is PNIPAM.

[0040] Take 15ml PNIPAM solution, dilute ten times, add 0.3203g MBA, N 2 Stir magnetically for 30min under protection; add 2.5043g AA under ice bath, and stir magnetically for 20min; then mix 0.1023g APS and 0.1023g Na 2 S 2 o 5 Dissolve in 5ml of deionized water respectively, add the...

Embodiment 3

[0043] Take 1.9027g NIPAM, 0.0355g MBA, 0.076g SDS and dissolve in 140ml deionized water, and bubble N at room temperature 2 Deoxygenation, magnetic stirring for 100 minutes; the reaction temperature was raised to 70 ° C, and 2 Keep warm for 30 minutes under protection;

[0044] Then dissolve 0.083g initiator APS in 10ml deionized water, add to the above solution, keep N 2 atmosphere, continue to react for 4 hours; then soak the obtained reactant in deionized water and dialyze for 7 days, change the water three times a day to remove residual reaction raw materials and electrolytes in the reaction system. The molecular weight cut-off of the dialysis bag used is 8000-14000. That is PNIPAM.

[0045] Take 15ml PNIPAM solution, dilute ten times, add 0.3203g MBA, N 2 Stir magnetically for 30min under protection; add 1.523g AA under ice bath, and stir magnetically for 20min; then mix 0.1023g APS and 0.1023g Na 2 S 2 o 5 Dissolve in 5ml of deionized water respectively, add the ...

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Abstract

The invention relates to a method for preparing ferriferous oxide-supported nano-hydrogel based on an interpenetrating network structure. The method comprises the following steps: dissolving N-isopropyl acrylamide, a crosslinking agent and an emulsifier in de-ionized water, performing stirring in a nitrogen atmosphere, preserving heat at 65 to 80 DEG C, then adding an initiator, continuing reaction for 0.5 to 4h, and performing dialysis to obtain PNIPAM; adding the crosslinking agent into an aqueous solution of the PNIPAM, performing stirring in the nitrogen atmosphere, adding AA, performing stirring, adding the initiator and a catalyst, performing reaction for 0.5 to 1.5h, and performing dialysis to obtain PNIPAM / PAA interpenetrating structured nano-hydrogel; adding Fe<2+> and Fe<3+> into the nano-hydrogel, adding ammonia water at room temperature, performing reaction for 1 to 3h, and performing dialysis. The method is simple in process and environment-friendly, and the raw materials are readily available; prepared magnetic hybrid gel is well dispersed in an aqueous medium, and has broad prospects in the fields of drug loading, controlled release and the like.

Description

technical field [0001] The invention belongs to the field of preparation of nano-hydrogels, in particular to a preparation method of ferric oxide-loaded nano-hydrogels based on an interpenetrating network structure. Background technique [0002] Hydrogel refers to a class of soft materials formed by physical or chemical cross-linking, which can absorb a large amount of water and maintain its three-dimensional structure. Smart nanohydrogels can respond to small changes in environmental information, such as temperature, pH, magnetism, light, etc., and produce corresponding volume changes, so they have important application values ​​in chemical sensors, controlled drug release, and material separation. Among them, temperature and pH, as two important environmental conditions, have attracted the attention of the outside world. The most typical monomers for preparing temperature-sensitive / pH-responsive nano-hydrogels are N-isopropylacrylamide (NIPAM) and acrylic acid (AA). nano...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08F220/54C08F222/38C08F220/06C08L33/24C08L33/02C08K3/22
CPCC08F220/06C08F220/54C08J3/075C08J2333/02C08J2333/24C08K2201/011C08L33/02C08L33/24C08L2205/02C08L2205/04C08K2003/2275C08F222/385
Inventor 鲁希华李晓晓李雪婷
Owner DONGHUA UNIV