Clobetasol propionate molecule capturer, and preparation method and applications thereof

A technology of clobetasol propionate and traps, applied in the field of molecular traps, can solve problems such as harming human health, ignorance, and destruction of hormone balance

Active Publication Date: 2017-05-31
GUANGXI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, driven by commercial interests in recent years, the abuse of hormones in the cosmetics industry is on the rise. This kind of drugs that should be used seriously is abused by some unscrupulous manufacturers and beauty salons as special ingredients for skin tenderness and whitening. "Seven-day freckle removal" an

Method used

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  • Clobetasol propionate molecule capturer, and preparation method and applications thereof
  • Clobetasol propionate molecule capturer, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Preparation of Clobetasol Propionate Molecular Capture

[0036] (1) Graphene oxide modified polyethylene filter plate

[0037] Place 4 pieces of polyethylene filter plates (diameter 5-10mm, thickness 2-3mm) in acetonitrile for several hours, take them out, and put them in jars; take 3.6mL of graphite oxide slurry with a concentration of 11.1mg / mL and add it to 6.4 In mL N,N-dimethylformamide, ultrasonically disperse into a graphene oxide sol and transfer it to a jar, place it on an oscillator and shake it at room temperature for 60 minutes, take out the filter plate, and dry it at 50°C for 1 hour; repeat coating Six times, the graphene oxide-coated polyethylene filter plate is obtained;

[0038] (2) Preparation of silanized graphene oxide coated filter plate

[0039] Put 50mL of ethanol and 20mL of water in a beaker, add 9.0mL of ammonia water, mix well and transfer to a three-necked flask, then add 20 pieces of graphene oxide-coated polyethylene filter plates, and...

Embodiment 2

[0050] 1. Preparation of Clobetasol Propionate Molecular Capture

[0051] Steps (1), (2) are the same as in Example 1.

[0052] (3) Preparation of molecularly imprinted polymer membranes containing clobetasol propionate by surface imprinting polymerization

[0053] Put 0.94g of clobetasol propionate and 9.4mL of 3-aminopropyltriethoxysilane into a beaker containing 20mL of acetonitrile, and ultrasonicate for 3min to form a pre-polymerization solution; then add 16 pieces of silanized Graphene oxide coated filter plate, sealed and protected from light for 8 hours; add 20mL tetraethyl orthosilicate, 4mL glacial acetic acid, 40mL absolute ethanol, stir well, transfer to a three-necked flask, add a stirrer, condenser, thermometer , nitrogen deoxygenation, constant temperature reaction at 30°C for 15 hours, and a molecularly imprinted polymer film containing clobetasol propionate was formed on the surface of the silanized graphene oxide-coated filter plate;

[0054] (4) Elution of...

Embodiment 3

[0060] 1. Preparation of Clobetasol Propionate Molecular Capture

[0061] Steps (1), (2) are the same as in Example 1.

[0062] (3) Preparation of molecularly imprinted polymer membranes containing clobetasol propionate by surface imprinting polymerization

[0063] Put 1.41g of clobetasol propionate and 14.1mL of 3-aminopropyltriethoxysilane into a beaker filled with 30mL of acetonitrile, and ultrasonicate for 3min to form a pre-polymerization solution; then add 24 pieces of silanized Graphene oxide coated filter plate, sealed and protected from light for 8 hours; add 30mL tetraethyl orthosilicate, 6mL glacial acetic acid, 60mL absolute ethanol, stir evenly, transfer to a three-necked flask, add a stirrer, condenser, thermometer , nitrogen deoxygenation, constant temperature reaction at 30°C for 15 hours, and a molecularly imprinted polymer film containing clobetasol propionate was formed on the surface of the silanized graphene oxide-coated filter plate;

[0064] (4) Elutio...

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Abstract

The invention discloses a clobetasol propionate molecule capturer. According to a preparation method, a graphene oxide modified polyethylene filter board is taken an internal support body, and synthesis of a clobetasol propionate membrane on the surface of the internal support body is carried out. In synthesis of the molecularly imprinted polymer membrane, clobetasol propionate is taken as a template molecule, 3-aminopropyltriethoxysilane is taken as a functional monomer, ethyl orthosilicate is taken as a cross-linking agent, and glacial acetic acid is taken as a silane hydrolysis condensating agent. The clobetasol propionate molecule capturer is a novel molecular imprinting-solid phase extraction integral material, is adopted in pretreatment of selective adsorption and dynamic extraction separation of trace illegally added clobetasol propionate in cosmetic samples with complex matrix so as to realize rapid separation detection on clobetasol propionate. The invention also discloses the preparation method of the clobetasol propionate molecule capturer. The preparation method is simple; cost is relatively low; organic solvent using amount is low, solid phase extraction operation is simple and rapid, and is high in efficiency.

Description

technical field [0001] The invention belongs to the technical field of molecular traps, in particular to a molecular trap for clobetasol propionate and its preparation method and application. Background technique [0002] Glucocorticoids are a class of commonly used clinical drugs obtained by modifying hydrocortisone as the structural basis. They have anti-inflammatory, anti-allergic, inhibiting fibroblast proliferation, and reducing serotonin production. Short-term use has certain tenderness on the skin. white effect. Clobetasol propionate (Clobetasol propionate, CBT) is a potent glucocorticoid, has strong anti-inflammatory, anti-itching effects, and is clinically used to treat neurodermatitis, contact dermatitis, seborrheic dermatitis, eczema, etc. , psoriasis, lupus erythematosus and other skin diseases. Clobetasol propionate belongs to the glucocorticoid substances banned in cosmetics. Long-term use of cosmetics containing such substances will cause thinning of the ski...

Claims

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Application Information

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IPC IPC(8): C08J7/16C08J7/12C08J7/06C08G77/26C08J9/26B01J20/26B01J20/30B01J20/20G01N30/02C08L23/06C08L83/08
CPCB01J20/20B01J20/268C08G77/26C08J7/06C08J7/12C08J7/16C08J9/26C08J2323/06C08J2383/08C08J2483/08G01N30/02
Inventor 李小燕王芳吴宗远刘敏刘莉朱晨谭学才雷福厚
Owner GUANGXI UNIV FOR NATITIES
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