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Composition based on a stabilized solution of active ingredients

A technology of active substances and compositions, applied in the field of medicine

Inactive Publication Date: 2017-05-31
娜塔莉亚·米克拉维娜·德卡奇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is no information in the literature on the use of solutions containing both dicathoxine and hyaluronic acid as a therapeutic drug

Method used

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  • Composition based on a stabilized solution of active ingredients
  • Composition based on a stabilized solution of active ingredients
  • Composition based on a stabilized solution of active ingredients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0192] Preparation of stable solutions and pharmaceutical compositions based on the solutions

[0193] Add 800ml of distilled water to the flask. 16g of sodium succinate, 50mg of succinic acid, and 1.2g of sodium chloride were sequentially added to the flask and mixed on a magnetic stirrer (600rpm) for 5-10min until the ingredients were completely dissolved. Then, 200 mg of dicathocin was added to the solution under constant stirring until it was completely dissolved, and molten high-molecular-weight hyaluronic acid (401kDa-2,500,000Da) was added and stirred on a magnetic stirrer until the high-molecular-weight hyaluronic acid was completely hydrated (dissolved).

[0194] Subsequently, the pH of the obtained solution was adjusted to 7.3 with succinic acid, if necessary, and finally the prepared solution was made up to 1000 ml with purified water.

Embodiment 2

[0196] Preparation of stable solutions

[0197] Repeat the steps of Example 1, except that sodium hyaluronate is used instead of high molecular weight hyaluronic acid.

Embodiment 3

[0199] Preparation of gel formulations of pharmaceutical compositions based on stable solutions

[0200] Add 800ml of distilled water to the flask. 200mg of dicathoxine, 1.42g of sodium lactate, 360mg of lactic acid, and 30g of glycerin were sequentially added to the flask and mixed on a magnetic stirrer (600rpm) for 5-10min until the ingredients were completely dissolved. Then, 5 g of high molecular weight hyaluronic acid (401 kDa-2,500,000 Da) was added to the solution under constant stirring and stirred on a magnetic stirrer until the hyaluronic acid was completely hydrated (dissolved). 30 g of hydroxypropylmethylcellulose was added to the solution, and the volume of the mixed solution was adjusted to 1000 ml with purified water and mixed. If necessary, add lactic acid or sodium lactate to adjust the pH of the solution to 7.315.

[0201] The preparation method based on dicathoxine and low-molecular hyaluronic acid stable solution was tested in a large range of component r...

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Abstract

This invention relates to pharmaceutical compositions (variants) based on a stabilized solution of two active ingredients, said stabilized solution of two active ingredients comprising, as first active ingredient, low-molecular weight hyaluronic acid and / or a pharmaceutically acceptable salt thereof, wherein the molecular mass of said acid or salt is from 100 kDa to 400 kDa or, in a variant, from 400 kDa to 2.5 MDa, and, as second active ingredient, Decametoxin or a water-soluble salt thereof, and a stabilizer in the form of a pharmaceutically acceptable salt that is capable of dissolving in water and dissociating in aqueous solutions into metal cations and acid residue anions, or a mixture of such salts, wherein the stabilizer is capable of forming water-soluble compounds with hyaluronic acid and / or a pharmaceutically acceptable salt thereof and Decametoxin or a water-soluble salt thereof, simultaneously. The stabilized solution further contains at least one pharmaceutically acceptable additive.

Description

technical field [0001] The invention belongs to the field of medicine, and particularly relates to a composition with anti-inflammatory, antibacterial, regeneration and moisturizing effects and can be used for treating skin and organ lesions, more particularly, it has inhibitory activity on the adhesion process. Background technique [0002] Adhesions are pathological fusions of tissue formed by fragments of scar tissue and appear in atypical foci of injury due to surgical trauma, infection, ischemia, or foreign body action. Adhesions may be thin bands of tissue resembling polyethylene membranes, or thick ribbons. The formation of adhesions is called the adhesion process. [0003] The formation of adhesions is caused by inflammatory processes that occur in diseases of internal organs, after surgery, infection and trauma. Although adhesions may occur between different organs, they most commonly occur in intestinal loops, fallopian tubes, ovaries, uterus, bladder, and heart....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/728A61K31/14A61K47/02
CPCA61K9/0014A61K9/0034A61K9/08A61K31/14A61K31/223A61K31/728A61K47/02A61K47/10A61K47/12A61K31/31A61K2300/00
Inventor 娜塔莉亚·米克拉维娜·德卡奇
Owner 娜塔莉亚·米克拉维娜·德卡奇