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Drug for preventing and treating fatty liver and obesity and application thereof in drug preparation

A technology of fatty liver, medicine, applied in the field of medicine

Active Publication Date: 2017-06-13
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the pharmacological effects of borapetoside E in the treatment of fatty liver and obesity

Method used

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  • Drug for preventing and treating fatty liver and obesity and application thereof in drug preparation
  • Drug for preventing and treating fatty liver and obesity and application thereof in drug preparation
  • Drug for preventing and treating fatty liver and obesity and application thereof in drug preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Tinospora chinensis was collected in Simao, Yunnan in 2012, with a dry weight of 15 kg, crushed, and extracted three times with 95% ethanol at room temperature by cold soaking (25 liters each time), for 5 days each time. Recover and concentrate under reduced pressure to obtain 1100 g of the extract, which was subjected to silica gel column chromatography and eluted with petroleum ether / acetone mixed solvent gradient (99:1 to 0:100) to obtain 7 components A-G. Component E (180 g) was subjected to silica gel column chromatography and eluted with a gradient of chloroform / methanol mixed solvent (40:1 to 5:1) to obtain three components E1-E3. Component E1 was repeatedly chromatographed on a Sephadex LH-20 column and eluted with methanol to obtain 5.3 g of pure compound borapetoside E. Identification of compound structures was confirmed by comparison and interpretation of spectral data.

[0031] 1. Effect of Borapetoside E on fatty liver in mice induced by high fat and high ...

Embodiment 2

[0047] Preparation of health food:

[0048] Take 15.5 mg of borapetoside E, add 200 mg of starch, 66.6 mg of lactose, 1 mg of menthol, and 50.6 mg of sodium carboxymethyl starch to make lozenges as a health food.

Embodiment 3

[0050] Preparation of injection preparations:

[0051] According to the method of Example 1, 50 mg of the compound borapetoside E of the present invention was first obtained, which was dissolved in 2 milliliters of propylene glycol, and the resulting solution was filtered and filled into ampoules under aseptic conditions.

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Abstract

The invention relates to new application of borapetoside E in preparing drugs for preventing and treating metabolic diseases of fatty liver, obesity and the like. A research discovers that a compound borapetoside E of which the dosage is40 mg / kg is capable of obviously reducing the level of triglyceride, cholesterol and free fatty acid in livers of HFGD (High Fat and Glucose Diet) induced mice; the obesity symptom of the HFGD induced mice is remarkably relieved, and energy metabolism of the HFGD induced mice is promoted; the action mechanism can be related to SREBP (Sterol Regulatory Element Binding Proteins) inhibition. The curative effect of the compound borapetoside E under the dosage is superior to that of 200mg / kg of metformin, and the compound borapetoside E can be used for preparing the drugs, healthcare products and functional food for preventing and treating the fatty liver and the obesity.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of medicine, and specifically relates to a compound borapetoside E and a new application of a pharmaceutical composition using the compound as an active ingredient in the preparation of drugs for preventing and treating fatty liver and obesity. [0003] technical background: [0004] In 2008, the World Health Organization estimated that there were 1.4 billion overweight adults, of which 500 million were obese patients. In 2030, the number of obese patients will reach 1 billion. Obesity is the main cause of metabolic diseases such as fatty liver, type 2 diabetes, cardiovascular disease and hypertension, which seriously affect people's quality of life and cause a lot of medical costs. Recent studies have found that sterol regulatory element binding proteins (SREBPs, Sterol regulatory element binding proteins transcription factors) have an important impact on maintaining the body's energy metabolism bala...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61P1/16A61P3/04A61P3/00A23L33/10
CPCA23V2002/00A61K31/365A23V2200/30A23V2200/332
Inventor 刘吉开熊文勇许宇辉逯艳婷王芳
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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