Water-dispersible acid-responsive lymphatic targeted slow-release carrier nano-carbon, preparation method and application
A technology of lymphatic targeting and slow-release carrier, which is applied in preparations for in vivo experiments, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of nano-carbon redispersion and preparation steps And time-consuming, nano-carbon is easy to agglomerate and other problems, to achieve excellent sustained-release effect, good drug loading rate, and avoid potential threats
Active Publication Date: 2020-08-04
SICHUAN UNIV
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Problems solved by technology
[0011] To sum up, in order to improve the clinical use value of nano-carbon, at least the following shortcomings of the existing technology must be solved: (1) nano-carbon is easy to agglomerate and difficult to redisperse; (2) the existing nano-carbon has failed to realize the significance of tumor treatment Drug loading on
However, this patent does not solve the problem of redispersion of nano-carbon; at the same time, there are fewer applicable drugs, which need to be anti-cancer drugs with amino, imino or hydroxyl groups with better activity; in addition, its preparation steps and time-consuming are long and the reaction process It is easy to cause waste of anticancer drugs in
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Embodiment 1
[0069] (1) Raw materials and reagents
[0070] Commercial activated carbon (Shanghai Hainuo Carbon Industry Co., Ltd.), conventional reagents were purchased from Haihong Experimental Instrument Co., Ltd.; mPEG-NH 2 (MW 2000) was purchased from Suzhou NordPayson Pharmaceutical Technology Co., Ltd., and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC, ≥99.0%) was purchased from J&K Chemical Ltd.; N-hydroxysuccinimide (HOSu, ≥98%) was purchased from AlfaAesar; 3-(4,5-dimethylthiazole-2)-2,5-diphenyltetrazolium bromide (MTT, commercial Name: thiazolyl blue) was purchased from Sigma; DMEM (Dulbecco's Modified Eagle Medium) high glucose medium was purchased from HyClone; fetal bovine serum (FBS) was purchased from HyClone; trypsin was purchased from Gibieo; ) was purchased from Gibico; fluorescein isothiocyanate (FITC, 90%) was purchased from Acros Organics; colon cancer cells (SW480) were purchased from West China Medical College of Sichuan University; epithelial cells (L929) ...
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Abstract
The invention provides a water-soluble acid-responsive lymphatic targeting drug sustained-release carrier nano-carbon, which is obtained by grafting activated carbon with a surface carboxyl content of 0.10-1.00 mmol / g and amino polyethylene glycol monomethyl ether. The grafting amount is 1.00-10.00%, and the particle diameter of the nano-carbon is 50-500nm. The invention also provides a preparation method of the nano-carbon, a medicament for tumor tracing and treatment using the nano-carbon as a drug carrier and a preparation method. The invention provides the application of the nano-carbon in preparing lymphatic tracer preparations. The invention provides the use of the obtained medicament in the preparation of drugs for treating tumors and performing tumor tracing. The nano-carbon obtained in the present invention has very excellent water dispersibility and redispersibility; the obtained nano-carbon can be used as an excellent anticancer drug carrier, and has the advantages of high drug loading, good slow-release effect and acidity targeting; the present invention has Very good application prospects.
Description
technical field [0001] The invention belongs to the field of tumor targeting tracing and treatment, and specifically relates to a water-dispersible acid-responsive lymphatic targeting drug slow-release carrier nano-carbon and a preparation method thereof, and also relates to a medicament prepared by the nano-carbon and an anti-tumor drug. Its preparation method, as well as the use of the nano-carbon in the preparation of lymphatic tracing and tumor treatment preparations and the use of the obtained medicament in the preparation of lymphatic tracing and tumor treatment drugs. Background technique [0002] Cancer is one of the culprits that endanger human health and threaten human life. The intractability of tumors lies in its multiple, recurrence and metastasis. In the entire development process of tumors, tumor metastasis and dissemination occupy a key position, and it is also one of the main reasons why cancer will become the most difficult disease for human beings. Tumor ...
Claims
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IPC IPC(8): A61K47/18A61K45/00A61K31/513A61K31/555A61K49/00A61P35/00
CPCA61K31/513A61K31/555A61K45/00A61K47/183A61K49/00
Inventor 谭鸿杨烈宋远庆叶恒周总光李洁华罗锋傅强
Owner SICHUAN UNIV