Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Bone repairing material and preparation method thereof

A technology for bone repair and composite materials, which is applied in the field of bone repair materials and their preparation, and can solve problems such as not meeting the needs of bone repair.

Inactive Publication Date: 2017-06-13
BEIJING AKEC MEDICAL
View PDF7 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main purpose of the present invention is to provide a bone repair material and its preparation method to solve the problem that bone repair materials in the prior art do not meet the bone repair needs of human bone defects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bone repairing material and preparation method thereof
  • Bone repairing material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] In addition, according to another aspect of the present invention, there is also provided a method for preparing the above-mentioned bone repair material, which includes the following steps: taking mammalian cancellous bone and sequentially boiling it in water, soaking it in a phosphoric acid solution, cooking it, and drying it to obtain a prepared Treating cancellous bone; placing the pretreated cancellous bone in sodium hydrogen phosphate solution or disodium hydrogen phosphate solution for modification to obtain modified cancellous bone; calcining the modified cancellous bone to obtain hydroxyapatite- β-tricalcium phosphate composite material; after adjusting the pH of the mixture of hydroxyapatite-β-tricalcium phosphate composite material and collagen solution, adding β transforming growth factor solution to the mixture, and then performing the first ice bath treatment, dried to obtain a bone repair material.

[0028]In the above-mentioned treatment steps, after a s...

Embodiment 1

[0043] Step 1. Select healthy and fresh 9-month-old Tibetan yak spine cancellous bone, and cut the cancellous bone of the spine and femur into 1cm 3 Small pieces, boiled in a pot for 4 hours, rinsed several times with clean water, placed in a drying oven, and dried at 120-140°C for 6-8 hours. Soak the dried cancellous bone in a phosphoric acid solution, the mass concentration of the phosphoric acid solution is 3%, and the soaking time is 3 hours. Cancellous bone was cooked in a pressure cooker at 125°C for 3 hours. Dried to obtain pretreated cancellous bone;

[0044] Step 2, adding the pretreated cancellous bone to an aqueous solution of disodium hydrogen phosphate with a mass concentration of 2%, soaking for 2 hours to obtain the modified cancellous bone;

[0045] Step 3. Calcining the modified cancellous bone. Specifically, heat the modified cancellous bone high temperature furnace to 400°C and keep it warm for 0.5 hours; continue to heat up to 500°C and keep it warm for 2...

Embodiment 2

[0051] Preparation process is identical with embodiment 1, and difference is:

[0052] In step 2, the pretreated cancellous bone is added to an aqueous solution of disodium hydrogen phosphate with a mass concentration of 0.5%, and soaked for 2.5 hours to obtain the modified cancellous bone;

[0053] In the step of adjusting the pH of the mixture in step 4, adjust the pH value to 8; in the first ice bath treatment, the stirring speed is 5000r / min, and the treatment time is 1h; in the second ice bath treatment, the stirring speed is 5000r / min, the treatment time is 1h; after the second ice-bath treatment step and before drying, let stand at 15°C for 5 hours. Change the amount of collagen acetic acid solution and β-transforming growth factor added. The dosage of cross-linking agent is 0.1% of collagen.

[0054] In the finally obtained bone repair material, the weight ratio of hydroxyapatite and β-tricalcium phosphate is 8:2, and the content of β transforming growth factor is 3...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides a bone repairing material and a preparation method thereof. The bone repairing material is of a porous structure, and the bone repairing material comprises a beta-transforming growth factor, hydroxyapatite, beta-tricalcium phosphate and collagen. The porous structure is good for proliferation and differentiation of bone cells. Meanwhile, the bone repairing material comprises the hydroxyapatite and the beta-tricalcium phosphate, and the disadvantages that the hydroxyapatite is too stable and the beta-tricalcium phosphate is too rapidly degraded are overcome; and the degradation speed of the material is balanced and is matched with a human skeleton repairing speed very well. The collagen can be used for promoting cell migration, adhesion and differentiation and adjusting cell growth. The beta-transforming growth factor can be used for promoting the proliferation and differentiation of periosteum mesenchymal cells, and the proliferation of the bone cells is promoted, so that the beta-transforming growth factor plays a very important role in a bone tissue metabolic process. To sum up, the bone repairing material provided by the invention has various advantages and can be matched with the human skeleton repairing speed, and the bone repairing requirements of human bone defects are met.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a bone repair material and a preparation method thereof. Background technique [0002] my country is entering an aging society, and age-related changes and accompanying diseases will lead to a large number of bone defect reconstruction needs. Traditional bone graft scaffold materials include xenograft bone, allograft bone, synthetic materials, etc. All of the above materials have certain limitations. Limitations: Allogeneic bone sources are limited; xenogeneic bone has source and price issues, and there are risks of spreading diseases and causing host immune rejection; the porosity, pore traffic, and pore size of synthetic materials are different from those of human cancellous bone. Different, it is unfavorable to the adhesion and proliferation of cells, and it is difficult to promote the differentiation and maturation of osteoblasts. [0003] Hydroxyapatite (HA) is the main ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/56A61L27/54A61L27/36A61L27/12A61L27/24
CPCA61L27/12A61L27/24A61L27/3608A61L27/365A61L27/3687A61L27/54A61L27/56A61L2300/252A61L2300/414A61L2430/02
Inventor 王刚
Owner BEIJING AKEC MEDICAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com