Chemical synthesizing method of creatine monohydrate

A technology of chemical synthesis and creatine monohydrate, which is applied in chemical instruments and methods, organic chemistry, cyanide reaction preparation, etc., can solve the problems of high cost and large waste of materials, and achieve low cost, good quality and simple process Effect

Inactive Publication Date: 2017-06-13
安徽省鸿运生物医药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Creatine monohydrate has a wide range of uses, but in the actual chemical synthesis, there are many kinds, but there is no high-purity and efficient synthesis method, so the traditional synthesis method has great disadvantages, such as a large waste of materials ,high cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A chemical synthesis method of creatine monohydrate, comprising the following steps:

[0021] ①. Prepare aqueous solutions of chloroacetic acid and methylamine, then take chlorine aqueous solution and methylamine aqueous solution at a mass ratio of 1:8, then react at a temperature of 5°C for 7 hours, and then discharge to obtain sarcosine The solution is ready for use;

[0022] ②. Heat the above-mentioned mixed solution to 45-95°C, and distill all the methylamine in the mixed solution;

[0023] 3. In the remaining solution in the material in the above-mentioned steps 2, add a neutralization decomposition reagent, carry out the methylamine chloride in the solution after the neutralization reaction;

[0024] ④. Concentrate the above solution under reduced pressure, control the temperature to 100° C., and concentrate under reduced pressure for 1 hour to obtain an aqueous solution of sarcosine;

[0025] ⑤. Filter the sarcosine aqueous solution obtained above, filter out t...

Embodiment 2

[0029] A chemical synthesis method of creatine monohydrate, comprising the following steps:

[0030] ①. Prepare aqueous solutions of chloroacetic acid and methylamine, then take chlorine aqueous solution and methylamine aqueous solution at a mass ratio of 1:12, then react at a temperature of 45°C for 15 hours, and then discharge to obtain sarcosine The solution is ready for use;

[0031] ②. Heat the above-mentioned mixed solution to 95°C, and distill all the methylamine in the mixed solution;

[0032] 3. In the remaining solution in the material in the above-mentioned steps 2, add a neutralization decomposition reagent, carry out the methylamine chloride in the solution after the neutralization reaction;

[0033] ④. Concentrate the above solution under reduced pressure, control the temperature to 120° C., and obtain an aqueous solution of sarcosine after the time of concentration under reduced pressure is 2 hours;

[0034] ⑤. Filter the sarcosine aqueous solution obtained ab...

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PUM

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Abstract

The invention discloses a chemical synthesizing method of creatine monohydrate, and relates to the technical field of processing of medical intermediates. The chemical synthesizing method comprises the following steps of preparing a methylamine solution and a chloroacetic acid solution to react; obtaining a creatine solution, thinning and filtering, washing and drying, so as to obtain a crude product of creatine monohydrate; recrystallizing, so as to obtain the creatine monohydrate. The chemical synthesizing method has the advantages that the technology is simple, and the method is scientific and systematic; by utilizing chloroacetic acid and methylamine to prepare the creatine monohydrate, the cost is low; the prepared creatine monohydrate has high purity and good quality, and obtaining rate is better.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical intermediate processing, in particular to a chemical synthesis method of creatine monohydrate. Background technique [0002] Creatine monohydrate is a pharmaceutical raw material and health product additive. It can inhibit the generation of muscle fatigue factors, reduce fatigue and tension, restore physical fitness, accelerate human protein synthesis, make muscles stronger, enhance muscle elasticity, reduce cholesterol, blood fat, and blood sugar levels, improve muscular atrophy in middle-aged and elderly people, and delay aging. Creatine monohydrate can be used as food additive, cosmetic surfactant, feed additive, beverage additive, pharmaceutical raw material and health product additive, and can also be directly made into capsules and tablets for oral administration. Creatine monohydrate has a wide range of uses, but it is diverse in actual chemical synthesis, but there is no high-purit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C277/08C07C279/14
CPCC07C277/08C07C227/08C07C279/14C07C229/12
Inventor 黄华
Owner 安徽省鸿运生物医药股份有限公司
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