Preparation method for pyridine ring sulfimide alkali metal salt
A technology of pyridine ring sulfonimide base and pyridine ring sulfonyl chloride is applied in the field of preparation of pyridine ring sulfonimide alkali metal salt, which can solve the problems of difficult separation and purification of products, complicated steps and the like, and achieves high yield and purity , the operation steps are short, the effect of easy separation and purification
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[0028] This embodiment provides a method for preparing alkali metal salt of pyridine cyclic sulfonimide, comprising the following steps:
[0029] (1) Under the protection of argon, mix pyridine ring sulfonyl chloride, sulfonamide, acid-binding agent and appropriate amount of organic solvent in the reaction flask under stirring conditions for reaction, the reaction temperature is -20 ~ 60 ℃, and the reaction time is 8-48h, forming an organic solution containing an imine compound, and removing the solid by-products generated in the organic solution after decompression and filtration;
[0030] (2) Under stirring conditions, the anhydrous alkali metal compound solid that will be 1.0 to 3 times the stoichiometric amount of the imine compound is added to the organic solution in step (1) in batches, and the reaction is continued for 5 to 20 hours. The insoluble matter was filtered off to obtain the crude product of alkali metal salt of pyridine cyclic sulfonylimide;
[0031] (3) sel...
Embodiment 1
[0050] The preparation of (2-pyridinesulfonyl) imide lithium, synthetic reaction route is as follows:
[0051] step one:
[0052]
[0053] Step two:
[0054]
[0055] Add 2-pyridinesulfonamide (79g, 0.5mol), 2-pyridinesulfonyl chloride (88.7g, 0.5mol), triethylamine (50.5g, 0.5mol), and 300mL acetonitrile into a 1000mL three-necked flask, stir magnetically, and react at room temperature After 12 hours, filter under reduced pressure to obtain a light brown solution.
[0056] Magnetic stirring, lithium carbonate (18.5g, 0.25mol) was added at room temperature, and after 10 hours of reaction, the insoluble matter was removed by filtration, and the organic solvent was removed by rotary evaporation to obtain a light yellow solid, which was recrystallized from acetonitrile / methylene chloride to obtain 130g white Solid product, 85% yield.
Embodiment 2
[0058] Preparation of Sodium (2-Pyridinesulfonyl)imide
[0059] step one:
[0060]
[0061] Step two:
[0062]
[0063] Add 2-pyridinesulfonamide (79g, 0.5mol), 2-pyridinesulfonyl chloride (88.7g, 0.5mol), triethylamine (50.5g, 0.5mol), and 300mL acetonitrile into a 1000mL three-necked flask, stir magnetically, and react at room temperature After 12 hours, filter under reduced pressure to obtain a light brown solution.
[0064] Magnetic stirring, sodium carbonate (26.5g, 0.25mol) was added at room temperature, and after 10 hours of reaction, the insoluble matter was removed by filtration, and the organic solvent was removed by rotary evaporation to obtain a light yellow solid, which was recrystallized from acetonitrile / methylene chloride to obtain 141g white Solid product, 88% yield.
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