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A preparation method of effective parts of traditional Chinese medicine for treating hyperlipidemia
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A technology of effective parts and hyperlipidemia, applied in the field of preparation of effective parts of traditional Chinese medicine, can solve the problems of large waste of medicinal material resources, long production cycle, instability, etc., achieve rational utilization, simple preparation method, and good application value Effect
Active Publication Date: 2020-10-16
GUANGZHOU YIPINHONG PHARMA +4
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[0003] However, due to the instability of the quality of Polygonum cuspidatum, the stability of the production process is reported to be very poor, and a large amount of third-class organic solvents ethyl acetate and acetone are used in the process, which has caused a certain burden on product quality control and environmental protection. The process is relatively complicated and the production cycle is long. Only the active ingredients of stilbenes in Polygonum cuspidatum are mainly developed and utilized, which wastes a lot of medicinal resources
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Embodiment 1
[0022] Embodiment 1: The preparation method of effective part composition:
[0023] 1. Take the prescribed amount of Polygonum cuspidatum medicinal material (with low emodin content), and grind it into coarse powder. Add 95% ethanol, heat and reflux for extraction three times (5 times, 1.5h, 4 times, 1h, 3 times, 0.5h), and filter.
[0024] 2. Concentrate the filtrate in vacuum (at a temperature of 50-65°C) to a clear paste with a relative density of 1.15-1.20.
[0025] 3. Add 8 times the amount of water to the clear paste, heat to a slight boil for 10 minutes, stir well, cool to room temperature, let stand for 12 hours, and centrifuge to obtain supernatant and sediment. treatment), add 0.5% activated carbon and boil for 10 minutes, filter it with a titanium rod while it is hot, and concentrate the filtrate in a vacuum at a temperature of 50-65°C to a clear paste with a relative density of 1.17-1.20.
[0026] 4. Add 3% ethanol in clear paste, stir evenly, let the crystals st...
Embodiment 2
[0032] Embodiment 2: The preparation method of effective part composition:
[0033] 1. Take the prescription amount of Polygonum cuspidatum medicinal material (with higher emodin content), and grind it into coarse powder. Add 95% ethanol, heat and reflux for extraction three times (5 times, 1.5h, 4 times, 1h, 3 times, 0.5h), and filter.
[0034] 2. Concentrate the filtrate in vacuum (at a temperature of 50-65°C) to a clear paste with a relative density of 1.15-1.20.
[0035] 3. Add 8 times the amount of water to the clear paste, heat to a slight boil for 10 minutes, stir well, cool to room temperature, let stand for 12 hours, and centrifuge to obtain supernatant and sediment. treatment), add 0.5% activated carbon and boil for 10 minutes, filter it with a titanium rod while it is hot, and concentrate the filtrate in a vacuum at a temperature of 50-65°C to a clear paste with a relative density of 1.17-1.20.
[0036] 4. Add 3% ethanol in clear paste, stir evenly, let the crysta...
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Abstract
The invention provides a method for preparing effective parts of traditional Chinese medicines for treating hyperlipemia. The method comprises the following steps: extracting polygonum cuspidatum with ethanol, filtering so as to obtain supernate and precipitate, decoloring the supernate, concentrating, adding ethanol, and crystallizing so as to obtain an effective part 1; and centrifuging the precipitate, extracting, and filtering, thereby obtaining an effective part 2. The effective part 2 prepared by using the method can overcome the defect that the medicinal effect is insufficient as the content of rheum emodin in conventional supernate is insufficient, in addition, the problems that the stability of production processes is poor as the quality of the medicinal material polygonum cuspidatum is instable can be overcome, and the defects that in the prior art solvents are retained and the environment is polluted as a great number of solvents such as ethyl acetate and acetone are used can be overcome. The method provided by the invention is simple, the traditional Chinese medicine resource, namely polygonum cuspidatum, is sufficiently utilized, reasonable utilization of the traditional Chinese medicine, namely polygonum cuspidatum, is achieved, and relatively good application values can be created.
Description
technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extraction, and more specifically relates to a preparation method of an effective part of a traditional Chinese medicine for treating hyperlipidemia. Background technique [0002] The traditional Chinese medicinePolygonum cuspidatum is the dry rhizome and root of the perennial herbPolygonum cuspidatum. It has a long history of being used in my country. Bitter and cold in nature and taste, it belongs to the liver, gallbladder, and lung meridian, beneficial to the gallbladder and reducing jaundice, clearing heat and detoxification, promoting blood circulation and removing blood stasis, eliminating phlegm and relieving cough, etc. It is clinically used to treat damp-heat jaundice, stranguria, leukorrhea, blood stasis, amenorrhea, and lung heat Cough, hot knot constipation and other diseases. Pharmacological studies have shown that Polygonum cuspidatum has pharmacological effec...
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