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Preparation method of artificial lens body material with anti-bacterial function and good biocompatibility

An intraocular lens, biocompatibility technology, applied in the direction of prosthesis, tissue regeneration, medical science, etc., can solve the problem of not being able to kill bacteria, achieve good biocompatibility, reduce the incidence, and improve antibacterial properties. Effect

Active Publication Date: 2017-06-27
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Our research team has conducted systematic research on the preparation and surface modification of intraocular lenses, and found that although the intraocular lens treated with plasma can change the wettability of the intraocular lens, it has a certain timeliness; Control bacterial adhesion for a certain period of time, but cannot kill bacteria

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Add 100ml of ethanol to a 250ml small beaker, stir magnetically, slowly add MMA, PEGMA and DMAEMA respectively, the concentrations of the three are 10 mg / ml, 2mg / ml and 2mg / ml, slowly add 20mg of initiator azo while stirring Diisobutyronitrile (AIBN), the reaction was carried out at 65°C for 24h. The method of cyclic precipitation-dissolution is used to realize the separation and purification of the product, and the obtained terpolymer is extruded to obtain the body material of the intraocular lens. After the body material is soaked in 1-bromoheptane ethanol solution, it is then used After washing with ethanol and water for several times and drying at room temperature, the final material was obtained.

[0021] The field emission scanning electron microscope test shows that the surface of the intraocular lens body material is smooth. The static contact angle test material surface water contact angle is 98±1.2 ° , The light transmittance is 91%. The atomic force micros...

Embodiment 2

[0023] Add 100ml of ethanol to a 250ml small beaker, stir magnetically, slowly add MMA, PEGMA and DMAEMA respectively, the concentrations of the three are 10 mg / ml, 5mg / ml and 1mg / ml, slowly add 20mg AIBN while stirring, the reaction 24h at 65°C. The method of cyclic precipitation-dissolution is used to realize the separation and purification of the product, and the obtained terpolymer is extruded to obtain the body material of the intraocular lens. After the body material is soaked in 1-bromoheptane ethanol solution, it is then used After washing with ethanol and water for several times and drying at room temperature, the final material was obtained.

[0024] The static contact angle test film layer shows a certain degree of hydrophilicity, and the contact angle is 75±1.5 ° , The light transmittance is 93%. The atomic force microscope observed the morphology and found that the surface has a very low roughness, and the RMS is 3.52±0.24 nm. The results showed that the materi...

Embodiment 3

[0026] Add 100ml of ethanol to a 250ml small beaker, stir magnetically, slowly add MMA, PEGMA and DMAEMA respectively, the concentrations of the three are 15 mg / ml, 1mg / ml and 10mg / ml respectively, slowly add 20mg AIBN while stirring, the reaction 24h at 65°C. The method of cyclic precipitation-dissolution is used to realize the separation and purification of the product, and the obtained terpolymer is extruded to obtain the body material of the intraocular lens. After the body material is soaked in 1-bromoheptane ethanol solution, it is then used After washing with ethanol and water for several times and drying at room temperature, the final material was obtained.

[0027] The surface of the material tested by the field emission scanning electron microscope is smooth and uniform. The static contact angle test film layer shows a certain degree of hydrophilicity, which is 105±2.3 ° , The light transmittance is 90%. The atomic force microscope observed the morphology and foun...

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Abstract

The invention relates to a preparation method of an artificial lens body material with an anti-bacterial function and good biocompatibility. The material is prepared simply and conveniently, pollution-free operation can be realized, the material is prepared in an extrusion forming mode, and industrial production can be realized to prepare the functional artificial lens body material; the antibacterial property, the anti-adhesion property and the biocompatibility of the surface of the artificial lens material can be improved; the body material is stable in chemical structure, resists fatigue and shearing, and can adapt to the internal environment of a human body; and by the anti-adhesion and sterilizing functions of the surface of the material, occurrence rate of posterior capsular opacification and entophthalmia is reduced after the artificial lens body material is implanted in eyes for a long time.

Description

technical field [0001] The invention specifically relates to the technical field of new materials, in particular to a preparation method of an intraocular lens body material with antibacterial function and good biocompatibility. Background technique [0002] Cataract is the first blinding eye disease in the world and also in my country. The current surgical treatment mainly uses phacoemulsification combined with intraocular lens (IOL) implantation. Although cataract surgery has been very successful in restoring the vision of patients, there are bacterial infections (such as endophthalmitis, Endophthalmitis), foreign body inflammatory reactions, surface inflammatory cell adsorption and postoperative complications due to the implantation of intraocular lens materials. Posterior capsule opacification (PCO) and other complications are the main reasons for severe impairment of visual function after intraocular lens implantation. Improving the antibacterial performance and biocom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/50A61L27/54C08F265/06C08F220/14C08F220/34
CPCA61L27/16A61L27/50A61L27/54A61L2300/404A61L2430/16C08F265/06C08L51/003C08F220/14C08F220/34
Inventor 王佰亮孙林叶子徐青文南开辉陈浩
Owner WENZHOU MEDICAL UNIV
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