Application of silkworm excrement sodium iron chlorophyllin in preparation of drugs for treating chronic inflammation type anemia
A technology for iron chlorophyllin and chronic inflammation, which is applied in the field of preparation of medicines for treating chronic inflammatory anemia, can solve the problem of not treating chronic inflammatory anemia, etc., and achieve the effects of improving blood routine level, increasing body weight, and improving binding force.
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Embodiment 1
[0020] The preparation of embodiment 1 silkworm excrement sodium iron chlorophyllide
[0021] 1) Rough extraction: grind the silkworm excrement, then add 4 times the weight of acetone to the powder, infiltrate for 2 hours, then perform seepage extraction, control the seepage rate to 3ml / min, collect the seepage, and recover the acetone to get a dark green color paste crude extract;
[0022] 2) Refining: Dissolving the above-mentioned crude extract with No. 120 gasoline and then going to the NKA-2 type macroporous adsorption resin column, and eluting with 50% ethanol (referring to containing 50 g of ethanol in 100 g of ethanol aqueous solution) and ethyl acetate successively, Discard the ethanol eluate, collect the ethyl acetate eluate, adjust the pH value of the ethyl acetate eluate to 3 with hydrochloric acid, let the layers stand, filter, discard the upper filtrate, and collect the filter residue;
[0023] 3) Saponification: Dissolve the filter residue with No. 120 gasoline...
Embodiment 2
[0026] Therapeutic effect of embodiment 2 silkworm excrement sodium iron chlorophyllin on chronic inflammatory anemia model rats
[0027] 1. Experimental method
[0028] The blood routine, serum iron metabolism indicators and inflammatory factor levels of the rat model of rheumatoid arthritis (CFA) established by injecting Freund's complete adjuvant into the toes are all in line with the characteristics of chronic inflammatory anemia, so we use the method of injecting Freund's complete adjuvant to the rats. Anemia of chronic inflammatory disease (ACD) model was established with complete adjuvant.
[0029] 40 male Sprague-Dawley rats were divided into 5 groups with 8 rats in each group, weighing 150-200g. Free feeding and drinking water were kept in standard polypropylene cages, the temperature of the animal room was 21-24°C, the relative humidity was 58-62%, and the light time was 12 hours per day.
[0030] Modeling of experimental rats: 8 rats in the blank control group wer...
Embodiment 3
[0045] Example 3 The clinical therapeutic effect of silkworm excrement sodium iron chlorophyllin on chronic inflammatory anemia
[0046] In order to prove the therapeutic effect of this medicine, select various chronic inflammatory anemia cases to take the medicine of the present invention and observe, take 30 days as a course of treatment, treat 2 courses of treatment, carry out system inspection respectively.
[0047] 1. The clinical effect of drugs on patients with hemodialysis inflammatory anemia
[0048] ⑴ General Information
[0049] Select 60 patients with hemodialysis inflammatory anemia, including 36 males and 24 females, with an average age of (53.6±3.5) years old. The above medical records were confirmed by routine blood tests, C-reactive protein, hepcidin, serum ferritin, and total iron binding capacity.
[0050] ⑵ treatment method
[0051] Take 4 tablets of silkworm iron sodium chlorophyllin each time, 3 times a day; take the medicine 1 hour after the meal, avo...
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