Emamectin benzoate effervescent tablets and preparation method thereof

A technology of benzoate effervescent tablet and emamectin, applied in the field of preparation of emamectin benzoate effervescent tablet, can solve the problems of cumbersome procedures and waste of organic solvents , to achieve the effect of good safety, simple processing, and slow disintegration

Inactive Publication Date: 2017-07-14
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, effervescent tablets mainly use wet granulation, the process is cumbersome, and some wet granulation wastes a lot of organic solvents

Method used

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  • Emamectin benzoate effervescent tablets and preparation method thereof
  • Emamectin benzoate effervescent tablets and preparation method thereof
  • Emamectin benzoate effervescent tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1) Take 1g emamectin benzoate technical, 4g tartaric acid, 4g sodium bicarbonate, 0.8g alkyl naphthyl sodium salt, 0.8g sodium lignosulfonate, 1.2g polyvinylpyrrolidone, 2g of diatomaceous earth and 6.2g of kaolin are added to the pulverizer to pulverize more than 200 meshes to prepare 20g powder.

[0025] 2) Take 8.5 g of the powder in step (1) and add it to a tablet press to make 8.5 g emamectin benzoate effervescent tablets. See the production process figure 1 , See the product appearance figure 2 .

Embodiment 2

[0027] 1) Take 1g of the original drug of emamectin benzoate, 4g of tartaric acid, 4g of sodium bicarbonate, 0.8g of alkylnaphthyl sodium salt, 0.8g of 2-naphthalenesulfonic acid formaldehyde polymer sodium salt, 1.2 g polyvinylpyrrolidone, 2 g diatomaceous earth, and 6.2 g kaolin are added to a pulverizer to pulverize 200 meshes to prepare 20 g powder.

[0028] 2) Take 8.5 g of the powder in step (1) and add it to a tablet press to make 8.5 g emamectin benzoate effervescent tablets. See the production process figure 1 , See the product appearance figure 2 .

Embodiment 3

[0030] 1) Take 1g emamectin benzoate technical, 4g tartaric acid, 4g sodium bicarbonate, 0.8g alkyl naphthyl sodium salt, 0.8g modified lignin sulfonate, 1.2g polyethylene Pyrrolidone, 2g of diatomaceous earth, and 6.2g of kaolin were added to a pulverizer and pulverized to 200 meshes to prepare 20g powder.

[0031] 2) Take 8.5g of the powder in step (1) and add it to a tablet press to make 8.5g emamectin benzoate effervescent tablets. See the production process figure 1 , See product appearance figure 2 .

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Abstract

The invention discloses a preparation method of emamectin benzoate effervescent tablets. The emamectin benzoate effervescent tablets comprise the following components in percentage by mass: 1-5% of an emamectin benzoate active compound, 10-20% of an acid source, 10-20% of an alkali source, 2-6% of a dispersant, 2-4% of a wetting agent, 2-6% of an adhesive, 3-20% of a disintegrant and 19-70% of stuffing. The preparation method comprises the following steps: (1) uniformly mixing and adding the raw materials into a crusher to be crushed to obtain powder; and (2) adding the powder into a tablet press to tablet. The emamectin benzoate effervescent tablets have the characteristics of being simple to process, accurate to meter, stable in performance, convenient to store, convey and use, good in safety and the like, and meanwhile, solves the problem that emamectin benzoate is easily optically degraded, and the storage period of the preparation is prolonged.

Description

Technical field [0001] The invention relates to a preparation technology of emamectin benzoate effervescent tablets. Background technique [0002] Emamectin benzoate has stomach toxicity and contact killing effect, is extremely active against lepidopteran insect larvae, and has good control effect on vegetable root knot nematodes. As a biological pesticide, emamectin benzoate has the characteristics of super high efficiency, low toxicity, and low residue. It is currently an important species for pest control on crops such as vegetables, fruit trees, cotton and rice. [0003] Emamectin benzoate has a broad insecticidal spectrum, high biological activity, low toxicity, environmental protection, and resistance to drugs. However, the existing processing formulations of emamectin benzoate are mainly emulsifiable concentrates, microemulsions, water emulsions and suspensions. Among them, a large number of organic solvents and emulsifiers are used in the processing of emulsifiable concent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/90A01N25/34A01P7/04
CPCA01N43/90A01N25/34
Inventor 冯建国沈亚明刘芳曹洪恩陈麒丞
Owner YANGZHOU UNIV
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