Method for preparing paeonol-ozagrel conjugate lipidosome through ethanol injection method

A technology of paeonol and conjugates, which is applied in the field of pharmaceutical preparation, can solve the problems of limitations, poor water solubility and fat solubility, etc., and achieve the effects of easy mastery, high drug loading and stable performance
CN106943352AInactive Publication Date: 2017-07-14上海海虹实业(集团)巢湖今辰药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
上海海虹实业(集团)巢湖今辰药业有限公司
Publication Date
2017-07-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for preparing a paeonol-ozagrel conjugate lipidosome through an ethanol injection method. The paeonol-ozagrel conjugate lipidosome is prepared from a paeonol-ozagrel conjugate, a phospholipid material, cholesterol, an inorganic solvent and a buffer solution. The method comprises the steps of stirring a prescription dosage of phosphate buffer solution and setting the temperature to 40 DEG C; weighing a prescription dosage of paeonol-ozagrel conjugate, soybean lecithin and cholesterol into the absolute ethyl alcohol for ultrasonic treatment for 4min, slowly adding the drug to the phosphate buffer solution by using a 1mL injector at a constant speed, further stirring for two hours and granulating the finally obtained suspension through a 0.80micron microfiltration membrane to obtain the paeonol-ozagrel conjugate lipidosome. According to the method, the bioavailability and the stability of a paeonol-ozagrel conjugate are improved, thrill is reduced and the drug action time is prolonged.
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Description

technical field

[0001] The invention relates to a method for preparing paeonol-ozagrel conjugate liposome by an ethanol injection method, and belongs to the technical field of medicine preparation. Background technique

[0002] Cardiovascular and cerebrovascular diseases are the main cause of death of the global population and seriously endanger human health. With the aging of the social population, the incidence is increasing day by day. Effective prevention and treatment of cardiovascular and cerebrovascular diseases are the focus of contemporary medical research

[0003] Thromboembolism is one of the important factors leading to cardiovascular and cerebrovascular diseases. Thromboembolic disease is a pathological process in which various intrinsic and extrinsic factors lead to intravascular thrombus formation and embolism, resulting in impaired tissue and organ function. Thromboembolic diseases centered on coronary artery thrombosis and cerebral thrombosis have high morbi...

Claims

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