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Uses of Pepper Essential Oil

A plant essential oil, the technology of the genus Piper, which is applied in the field of the preparation of medicines and health products for the treatment and prevention of Alzheimer's disease of the essential oil of the genus Piper, can solve the problems such as the treatment or prevention of Alzheimer's disease that have not been reported in the literature, and achieve improvement Effects of toxicological safety, long half-life, good fat solubility

Active Publication Date: 2020-10-27
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the literature has mainly reported that the essential oils of the genus Piper have biological activities such as insecticidal, antibacterial, antioxidant, and mosquito repellent activities, but there is no report in the literature that the essential oils of the genus Piper can treat or prevent Alzheimer’s disease in this patent
In addition, there is no previous patent related to the use of the essential oil of pepper plants in this patent to treat or prevent Alzheimer's disease

Method used

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  • Uses of Pepper Essential Oil
  • Uses of Pepper Essential Oil
  • Uses of Pepper Essential Oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 : Preparation of Essential Oils from Pepper Plants by Steam Distillation

[0029] The South China pepper (Piper.austrosinense), the mangosteen (Pseudo konjac, P.sarmentosum Roxb), the mangosteen (P.hancei Maxim), the heather (P.wallichii), the big leaf konjac (P.laetispicum), the gland vein Konjac (P.bavinnum), P.puberulum, P.betle, P.senporeiense Yamam.inContrib.Fl.Kainan., American tree pepper (P.aduncum), Hainan Konjac (P.hainanense), P.thomsonii (C.DC.) Hook.f., P.boehmeriaefolium (Miq.) C.DC, P.flaviflorum C. DC.), pepper (P.nigrum L.), P. hispidimervium C.DC. stems and leaves were crushed by a small pulverizer, weighed 2kg of the powder and placed it in a steam distillation flask. Soak in pure water overnight, reflux for 6 hours on a volatile oil extractor (keep slightly boiling), collect the refluxed liquid and extract it with ether for 3 times, then dry it with anhydrous sodium sulfate, and evaporate the ether solvent to obtain the essential oil of pe...

Embodiment 2

[0030] Example 2: Preparation of Essential Oils from Pepper Plants by Carbon Dioxide Supercritical Extraction

[0031] The South China pepper (Piper.austrosinense), the mangosteen (Pseudo konjac, P.sarmentosum Roxb), the mangosteen (P.hancei Maxim), the heather (P.wallichii), the big leaf konjac (P.laetispicum), the gland vein Konjac (P.bavinnum), P.puberulum, P.betle, P.senporeiense Yamam.inContrib.Fl.Kainan., American tree pepper (P.aduncum), Hainan Konjac (P.hainanense), P.thomsonii (C.DC.) Hook.f., P.boehmeriaefolium (Miq.) C.DC, P.flaviflorum C. DC.), pepper (P.nigrum L.), P. hispidimervium C.DC. stems and leaves were crushed by a small pulverizer, weigh 2kg of powder and place it in a carbon dioxide supercritical extractor, extract, Get pepper essential oil.

Embodiment 3

[0032] Example 3: Preparation of Essential Oils from Pepper Plants by Solvent Extraction

[0033] The South China pepper (Piper.austrosinense), the mangosteen (Pseudo konjac, P.sarmentosum Roxb), the mangosteen (P.hancei Maxim), the heather (P.wallichii), the big leaf konjac (P.laetispicum), the gland vein Konjac (P.bavinnum), P.puberulum, P.betle, P.senporeiense Yamam.inContrib.Fl.Kainan., American tree pepper (P.aduncum), Hainan Konjac (P.hainanense), P.thomsonii (C.DC.) Hook.f., P.boehmeriaefolium (Miq.) C.DC, P.flaviflorum C. DC.), pepper (P.nigrum L.), pepper (P.hispidimervium C.DC.) stems and leaves were crushed by a small pulverizer, weighed 2kg powder and placed it in the extractor, and added 4 times the amount of petroleum ether, cold-soaked and extracted three times for 48 hours each time, combined the extracts, reduced pressure to recover the solvent, and obtained the essential oil of the genus Piper.

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Abstract

The invention discloses application of pepper plant essential oil, namely application of pepper plant essential oil in the preparation of drugs or health products for treating and preventing Alzheimer's disease; the application of the pepper plant essential oil in the preparation of drugs or health products for treating and preventing Alzheimer's disease is attributed to the action mechanism of the pepper plant essential oil in significantly inhibiting acetylcholinesterase activity, and in-vivo activity experiment further verifies that the pepper plant essential oil can significantly improve Alzheimer's disease and its symptoms, and the application is totally different from that of existing drugs or health products of pepper plant essential oil.

Description

technical field [0001] The present invention relates to new uses of essential oils of plants belonging to the genus Piper, especially to the use of essential oils of the genus Piper in preparing medicines and health products for treating and preventing Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD), also known as Alzheimer's disease, is a progressive neurodegenerative disease with an insidious onset. Clinically, it is characterized by generalized dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and changes in personality and behavior. The etiology of AD is still unknown. In recent years, many researchers at home and abroad have put forward various hypotheses from different angles, such as hypocholinergic hypotheses, inflammation and immunity hypothesis, gene mutation hypothesis, amyloid hypothesis, oxidative stress and excitotoxicity hypothesis. At present, the incidence of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/67A61P25/28
CPCA61K36/67
Inventor 许敏韩佳欣向彩朋李海舟杨崇仁
Owner KUNMING UNIV OF SCI & TECH
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