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Pepsin coating tablet containing traditional Chinese medicine extract

A technology of pepsin and extract, applied in the field of medicine, can solve the problems of unsatisfactory effect of pepsin tablets, too little pepsin, increased reactivity of various stimuli, etc., and achieve the effect of solving indigestion symptoms

Inactive Publication Date: 2017-07-25
THE THIRD PEOPLES HOSPITAL OF QINGDAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Abnormal gastric sensory function and hypersensitivity of visceral nerves may increase the responsiveness of FD patients to various stimuli
The existing pepsin tablets only simply provide the pepsin needed by the human body, but they cannot fundamentally solve the essential problem of too little pepsin secreted by the principal cells of the gastric glands. In addition, pepsin needs to be activated by gastric acid to make pepsinogen Become active pepsin and provide a suitable acidic environment for pepsin. The secretion of gastric acid and pepsin reflects the digestive function of the stomach for food
At the same time, different enzymes have different optimal pH values, and the optimal pH value of pepsin is 1.8. Therefore, if a suitable gastric environment cannot be provided first, the effect of simply taking pepsin tablets is often not ideal, and the symptoms are not cured.

Method used

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  • Pepsin coating tablet containing traditional Chinese medicine extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A pepsin-coated tablet containing traditional Chinese medicine extract, consisting of a tablet core and a coating film, based on the mass of the coated tablet, the tablet core contains 5% of Nitraria japonica extract and 7% of cinnamon extract , rose fruit extract 5%, pepsin 0.01%, sucrose powder 70%, sodium starch glycolate 2%, magnesium stearate 0.2%.

[0023] The Nitraria extract is prepared by the following method: prepare the dried Nitraria japonica as raw material, wash, mix and cold-soak with 60% ethanol for 4 hours, filter to obtain the filtrate, compress the filtrate to 1 / 5 of the original volume, and then purify Rinse with water and reuse to obtain the initial extract; the initial extract is adsorbed with macroporous resin, and then eluted with 50% ethanol to the macroporous resin column, and the eluents are combined and mixed to obtain the crude extract; then the crude extract is reduced Concentrate under pressure to 1 / 5 of the original volume, then stand sti...

Embodiment 2

[0030] A pepsin-coated tablet containing traditional Chinese medicine extract, consisting of a tablet core and a coating film, based on the mass of the coated tablet, the tablet core contains 8% of Nitraria japonica extract and 8% of cinnamon extract , rose fruit extract 7%, pepsin 0.01%, sucrose powder 65%, sodium starch glycolate 3%, magnesium stearate 0.1%.

[0031] The Nitraria extract is prepared by the following method: prepare dried Nitraria japonica as raw material, wash, mix and cold-soak with 80% ethanol for 3 hours, filter to obtain a filtrate, compress the filtrate to 1 / 5 of the original volume, and then purify Rinse with water and reuse to obtain the initial extract; the initial extract is adsorbed with macroporous resin, and then eluted with 40% ethanol to the macroporous resin column, and the eluents are combined and mixed to obtain the crude extract; then the crude extract is reduced Concentrate under pressure to 1 / 5 of the original volume, then stand still, fi...

Embodiment 3

[0038] A pepsin-coated tablet containing traditional Chinese medicine extract, consisting of a tablet core and a coating film, based on the mass of the coated tablet, the tablet core contains 10% of Nitraria japonica extract and 10% of cinnamon extract , Rosa rose fruit extract 10%, pepsin 0.01%, sucrose powder 60%, sodium starch glycolate 2%, magnesium stearate 0.5%.

[0039] The Nitraria extract is prepared by the following method: prepare dried Nitraria japonica as raw material, wash, mix and cold-soak with 90% ethanol for 3 hours, filter to obtain a filtrate, compress the filtrate to 1 / 4 of the original volume, and then purify Rinse with water and reuse to obtain the initial extract; the initial extract is adsorbed with macroporous resin, and then eluted with 60% ethanol to the macroporous resin column, and the eluents are combined and mixed to obtain the crude extract; then the crude extract is reduced Concentrate under pressure to 1 / 4 of the original volume, then stand s...

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Abstract

The invention belongs to the field of medicines, and particularly relates to a pepsin coating tablet containing a traditional Chinese medicine extract. The pepsin coating tablet consists of a tablet core and a coating film, wherein according to the mass of the coating tablet, the tablet core comprises 5 to 10% of nitraria schoberi fruit extract, 5 to 10% of cortex cinnamomi extract, 5 to 10% of rosa davurica fruit extract, and 0.01 to 0.02% of pepsin. The pepsin coating tablet has the advantages that a new pepsin tablet formula is provided; by adding the nitraria schoberi fruit extract, the cortex cinnamomi extract and the rosa davurica fruit extract, the energy of main cells and parietal cells of gastric gland can be stimulated, the normal pepsinogen and gastric acid excretion ability is restored, and the problem of less excretion of pepsin is fundamentally solved; a proper acid environment is provided for the pepsin, the function of the pepsin is fully realized, and the symptom of poor digestion is solved.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a pepsin-coated tablet containing traditional Chinese medicine extracts. Background technique [0002] Functional dyspepsia (FD) is a group of clinical syndromes with upper abdominal pain, discomfort, fullness, belching, loss of appetite and nausea as the main symptoms, and organic diseases causing these symptoms are excluded after examination. In recent years, the prevalence rate has been high, and the statistics in European and American countries have reached 19%-41%, with an average of 32%; in China, it has been 18%-45%, accounting for 20%-40% of patients with digestive tract diseases. [0003] The pathogenesis of FD is still unclear, and it may be closely related to gastrointestinal motor dysfunction and sensory dysfunction. Psychological and neurological factors, as well as environment, diet, gastrointestinal hormones, gastric acid and HP infection are involved in the pathogenesis, w...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K9/36A61P1/14A61K36/738
CPCA61K38/488A61K9/2826A61K36/489A61K36/54A61K36/738A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 张国联
Owner THE THIRD PEOPLES HOSPITAL OF QINGDAO
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