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Chitosan-containing fibroin tissue repair material

A technology of silk protein and tissue repair, which is applied in the field of silk protein tissue repair materials, can solve the problems that it is difficult to achieve blood vessel formation and tissue repair functions, and achieve good tissue repair functions and good effects of promoting blood vessel formation

Inactive Publication Date: 2017-07-28
WUHU YANGZHAN NEW MATERIAL TECH SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing technologies are pure silk fibroin materials, and it is difficult to achieve the ideal function of promoting angiogenesis and tissue repair.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A chitosan-containing silk protein tissue repair material, which is a membrane containing silk protein, with an average internal pore density of 1-3000 / mm 2 , The average pore diameter is 1-500μm, and the membrane contains the following raw materials in parts by weight: 105 parts of silk protein solution, 9 parts of silk protein nanofiber solution, 2 parts of chitosan acetic acid solution, 1 part of nimesulide .

[0023] The chitosan acetic acid solution is prepared by mixing chitosan and acetic acid with a weight concentration of 1% in a mass ratio of 1:8.

[0024] The silk protein nanofiber solution is prepared by the following method: take the silk protein solution in a 60°C constant temperature box and concentrate to half of the original volume, then transfer it to a fume hood and concentrate to a mass fraction of 20% to obtain a concentrated solution. The solution is stored in a refrigerator at 4°C for 2 days, and then the concentrated solution is diluted with water to ...

Embodiment 2

[0032] A chitosan-containing silk protein tissue repair material, which is a membrane containing silk protein, with an average internal pore density of 1-3000 / mm 2 , The average pore diameter is 1-500μm, and the membrane contains the following raw materials in parts by weight: 150 parts by weight of silk protein solution, 10 parts of silk protein nanofiber solution, 3 parts of chitosan acetic acid solution, and 2 parts of nimesulide .

[0033] The chitosan acetic acid solution is prepared by mixing chitosan and acetic acid with a weight concentration of 1% in a mass ratio of 1:8.

[0034] The silk protein nanofiber solution is prepared by the following method: take the silk protein solution in a 60°C constant temperature box and concentrate to half of its original volume, then transfer it to a fume hood and concentrate it to a mass fraction of 30% to obtain a concentrated solution. The solution is stored in a refrigerator at 4°C for 2 days, and the concentrated solution is diluted ...

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PUM

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Abstract

A chitosan-containing fibroin tissue repair material is a fibroin-containing membranoid substance. Internal average pore density is 1-3000 per mm2, average pore size is 1-500um, and the membranoid substance comprises, by weight, 105-150 parts of fibroin solution, 9-10 parts of fibroin nanofiber solution, 2-3 parts of chitosan acetic acid solution and 1-2 parts of nimesulide. The invention relates to the field of biomaterials and fibroin. The biomaterials for repairing damaged large tissue and complex organs must be capable of promoting blood vessel formation to enable the large tissue and the complex organs to have biological functions. However, in the prior art, pure silk fibroin repair materials are in the majority and are difficult to realize ideal functions in promoting blood vessel formation and tissue repair, and that the chitosan-containing fibroin tissue repair material has better tissue repair effect.

Description

Technical field [0001] The invention relates to the field of biological materials and silk protein, in particular to a silk protein tissue repair material containing chitosan. Background technique [0002] Tissue engineering technology is a new method used to treat tissue and organ defects, which is composed of biological scaffolds, cells, growth factors and other elements. Among them, biological scaffolds play an important role in tissue engineering as a physical support for cell growth, proliferation and formation of new tissues. Tissue engineering aims at restoring and reconstructing the structural and functional integrity of damaged tissues or organs, but the repair of complex tissues and organs cannot be solved today. Large tissues and complex organs are not like simple thin tissues that can obtain nutrients and oxygen through the diffusion of small molecules. They need to pass through a huge vascular system to obtain nutrients and oxygen. Biomaterials for repairing damage...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/54A61L27/22A61L27/20
CPCA61L27/56A61L27/20A61L27/227A61L27/54A61L2300/216A61L2300/232A61L2300/404A61L2300/41A61L2430/34C08L89/00C08L5/08
Inventor 吴长应
Owner WUHU YANGZHAN NEW MATERIAL TECH SERVICE CO LTD
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