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Preparation method of high biocompatibility GQD/Trolox composite material

A composite material and adaptable technology, applied in the direction of luminescent materials, chemical instruments and methods, etc., can solve the problems of the final quantum dot fluorescence performance, the thickness of the "shell" is difficult to control, and the experimental conditions are harsh. The effect of uniform dispersion and good biological adaptability

Inactive Publication Date: 2017-08-04
WUHAN UNIV OF TECH
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Moreover, the current method generally adopted is to prepare quantum dots with a "core-shell structure". The experimental conditions are harsh, and materials such as strong acids and alkalis are usually used, and the thickness of the "shell" of the final material is difficult to control, which may affect the final quantum dots. The fluorescent performance of the

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  • Preparation method of high biocompatibility GQD/Trolox composite material
  • Preparation method of high biocompatibility GQD/Trolox composite material
  • Preparation method of high biocompatibility GQD/Trolox composite material

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Embodiment 1

[0034] Preparation of sterile solution steps:

[0035] Preparation of sterile high-purity graphene quantum dot solution: Take 10 mg of graphene quantum dots and irradiate with ultraviolet light for 2 days, add 9.8 ml of sterile water to constant volume, and then 300W high-frequency ultrasound. The graphene quantum dot solution was obtained by dialysis with a 1WDa dialysis membrane under the condition of ultraviolet irradiation, and then freeze-dried to obtain a powder, which was prepared into a sterile high-purity graphene quantum dot solution of 1 mg / ml with sterile deionized water for use.

[0036] Take 10mg Trolox powder and irradiate it with ultraviolet light for 2 days. After adding 9.8ml of absolute ethanol to constant volume, 300W high-frequency ultrasound was used to obtain sterile Trolox absolute ethanol solution for use.

[0037] Preparation steps of GQD / Trolox composite material: The obtained graphene quantum dot solution and Trolox solution are mixed according to 2:...

Embodiment 2

[0039] Preparation of sterile solution steps:

[0040] Preparation of sterile high-purity graphene quantum dot solution: Take 10 mg of graphene quantum dots and irradiate them with ultraviolet rays for 2 days, add 9.8 ml of sterile water to constant volume, and then 400W high-frequency ultrasound. The graphene quantum dot solution was obtained by dialysis with a dialysis membrane of 8000 Da under the condition of ultraviolet irradiation, and the powder was obtained by freeze-drying, and a 1 mg / ml sterile high-purity graphene quantum dot solution was prepared with sterile deionized water for use.

[0041] Take 10mg Trolox powder and irradiate it with ultraviolet light for 2 days. Add 9.8ml of absolute ethanol to constant volume, and then 400W ultrasonic to obtain sterile Trolox absolute ethanol solution for use.

[0042] Preparation steps of GQD / Trolox composite material: The obtained graphene quantum dot solution and Trolox solution are mixed according to 3:1, stirred and mix...

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Abstract

The invention relates to a preparation method of a high biocompatibility GQD / Trolox composite material. The GOD / Trolox composite material comprises graphene quantum dots GQD and Trolox modified on the graphene quantum dots GQD. The preparation method comprises the following steps: 1) preparing a sterile high purity graphene quantum dot solution and a sterile Trolox absolute ethyl alcohol solution under a condition of ultraviolet radiation; 2) mixing and stirring the graphene quantum dot solution and the Trolox absolute ethyl alcohol solution obtained in the step 1); and 3) stirring the mixture at a controlled temperature, and performing ultrasonic treatment, washing, dialysis and freezing and drying to obtain Trolox modified graphene quantum dots. A GQD / Trolox compound prepared by the preparation method is stable to combine and uniform in grain size dispersibility, and the obtained GQD / Trolox composite material has good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of organic materials, and in particular relates to a preparation method of a highly biologically adaptable GQD / Trolox composite material. Background technique [0002] Nanomaterials are widely used in various fields, and the application of nanomaterials in biology is gradually rising. Nanoscale materials have the characteristics of small particle size and large specific surface area, and quantum effects dominate the physical and chemical properties of materials. Now more and more experiments have begun to confirm that not all nanomaterials are beneficial and harmless. Because the particle size of nanomaterials is very small, the possibility of their interaction with biological tissues will be greatly increased. Materials at the nanometer level can produce unexpected toxic side effects. Lin uses about 20nm SiO 2 When nanoparticles stimulated human bronchial carcinogenic cells, it was found that the develop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65C09K11/02
CPCC09K11/025C09K11/65
Inventor 王一龙严韬阳晓宇叶翠芳王倚天张钊赵悦谌玉莲
Owner WUHAN UNIV OF TECH