Unlock instant, AI-driven research and patent intelligence for your innovation.

A temperature sensing and multi-channel imaging method based on up-conversion materials

A conversion material and multi-channel technology, applied in the field of temperature sensing and multi-channel imaging based on up-conversion materials, can solve the problems of poor practicability and less information

Active Publication Date: 2020-05-05
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the traditional up-conversion temperature sensor is less practical
[0009] In addition, although there are many applications of up-conversion materials in biological internal topography imaging, pure topographic imaging itself can only give us a basic understanding of the location of a certain substance in a living organism, while other information about its location (For example, temperature) is unknown, resulting in too little information obtained during the local detection process of the organism, and it is impossible to comprehensively and effectively judge the overall situation of the invisible (referring to the naked eye observation level) area in the organism, such as the detection of HeLa in the body. Cell spreading area and survival temperature

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] We synthesize upconversion materials via a hydrothermal method:

[0066] (1) First, 0.4mmol YCl 3 , 0.4mmol YbCl 3 and 0.4 mmol ErCl 3 The solutions were mixed, added to a flask mixed with 1-octadecene and oleic acid, and the solution was heated to 160° C. for 30 min under the protection of argon, and then cooled to room temperature.

[0067] (2) Then 5 mL of methanol solution (containing 1.6 mmol of NH 4 F and 1 mmol of NaOH) were added to the flask and continued to stir for 30 min. After the methanol was evaporated off, the solution was heated to 310° C. for 1 h under the protection of argon, then cooled to room temperature. By adding ethanol, the upconversion material nanoparticles ytterbium-erbium double-doped NaYF 4 The precipitate was collected by centrifugation.

[0068] The ytterbium-erbium double-doped NaYF of the present embodiment 4 Abbreviated as NaYF 4 :Er 3+ ,Yb 3+ , wherein the mass percentage of ytterbium ions is 20%, and the mass percentage of...

Embodiment 2

[0084] Except that the concentration of the up-conversion material is 1 mM, and the concentration of rhodamine 6G is 0.5 mM, other preparation and test methods and conditions are the same as in Example 1.

Embodiment 3

[0086] Except that the concentration of the up-conversion material is 1 mM, and the concentration of rhodamine 6G is 0.83 mM, other preparation and test methods and conditions are the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a temperature sensing and multichannel imaging method based on an upconversion material and particularly relates to a composite material based on the upconversion material, a preparation method of the composite material and application of the composite material in temperature sensing and multichannel imaging. The composite material comprises the upconversion material and a fluorescent material, wherein the upconversion material serves as the donor material, the fluorescent material serves as the receptor material, and a fluorescence resonance energy transfer (FRET) phenomenon forms between the upconversion material and the fluorescent material. The composite material has the advantages that high-precision organism in-vivo temperature sensing is achieved by changing temperature by the aid of the influence of temperature on the FRET phenomenon; by controlling the particle size of quantum dots in the composite material or rhodamine concentration ratio, multicolor-adjustable light emitting of the composite material can be achieved; the biological morphology imaging of the upconversion material in traditional application is combined with the newly introduced temperature sensing technology, and accordingly multichannel imaging in one excitation process can be achieved.

Description

technical field [0001] The invention relates to a temperature sensing and multi-channel imaging method based on an up-conversion material, in particular to a composite material based on an up-conversion material, its preparation method and its application in temperature sensing and multi-channel imaging. Background technique [0002] Upconversion materials are a class of materials that can emit short-wavelength (high photon energy) light under long-wavelength (low photon energy) light excitation, which is completely opposite to the traditional short-wavelength excitation long-wavelength materials. effect, and this anomalous phenomenon is called anti-Stokes luminescence. This kind of material mostly uses near-infrared light to excite visible light. Near-infrared light source has a high penetration depth and is not easy to cause the background effect of biological fluorescence, so it has an important application prospect in biological imaging. [0003] Up-conversion materials...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/85C09K11/88C09K11/06G01K11/00
CPCC09K11/06C09K11/7773C09K11/883C09K2211/1007C09K2211/1088G01K11/00
Inventor 陈锐喻萱池周冠臣赵逢焕
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA