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A helical icosahedral substrate for laser desorption ionization mass spectrometry

An icosahedral, ionizing mass spectrometry technique, applied in the field of helical tetrahedral structure substrates, can solve problems such as energy dissipation enhancement, and achieve enhanced light absorption process, enhanced ionization process, and large specific surface area. Effect

Active Publication Date: 2019-11-08
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The research group of Professor Lu Nan of Jilin University has prepared an ordered array of silicon nanocones by photolithography. Experiments have found that the laser absorption efficiency is related to the microstructure of the substrate. Increasing the specific surface area can increase the absorption rate, but the energy dissipation will also increase.

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  • A helical icosahedral substrate for laser desorption ionization mass spectrometry
  • A helical icosahedral substrate for laser desorption ionization mass spectrometry
  • A helical icosahedral substrate for laser desorption ionization mass spectrometry

Examples

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Embodiment 1

[0028] Example 1 Surface-assisted laser desorption ionization substrate based on helical icosahedral structure for detection of trace explosives

[0029] figure 1 The working principle of the three-dimensional substrate based on the helical icosahedral structure for surface-assisted laser desorption ionization detection is schematically shown. Among them, the main body 11 of the substrate is generally selected from highly doped single crystal silicon, its resistivity is 0.01-100 Ω·cm, and its thickness is 525 μm; the two-photon printed helical tetrahedron structure skeleton 12 has a structural period L of 1 μm. The precision (bone beam diameter) is 200nm, and a layer of colloidal gold particles with a thickness of 100nm is adsorbed on the surface of the skeleton by electroless plating. The helical tetrahedral structure was heat-treated at 150°C for 5 minutes in an inert gas atmosphere, and then cooled naturally to room temperature. The sample containing the substance to be d...

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Abstract

The invention discloses a spiral icositetrahedron structure substrate applied to laser desorption ionization mass spectrometry. The substrate is a three-dimensional network-like structure; a layer of noble metal is covered on the surface of the substrate; the substrate can be coupled with the laser and is capable of absorbing and transferring laser energy to analyte molecules as well as desorbing and cracking into charged molecular fragments; the spiral icositetrahedron structure (Gyroid structure) meets the following relation expressed as a formula as shown in description. In the formula, L is the cycle of the spiral icositetrahedron structure; t is adjustment of the shape of the spiral icositetrahedron structure.

Description

technical field [0001] The invention belongs to the field of matrix-free mass spectrometry analysis, and in particular relates to a helical icosahedral substrate used for laser desorption ionization mass spectrometry. Background technique [0002] Laser Desorption / Ionization (LDI) is an important "soft ionization" technology in the field of mass spectrometry, which is mainly used for the analysis and identification of biological macromolecules (such as polypeptides, proteins, etc.) and cells and tissues. The laser desorption ionization (MALDI) technology won the 2002 Nobel Prize in Chemistry. The matrix is ​​a double-edged sword. Although it facilitates the LDI process, it is easily affected by the salt content in the sample and seriously interferes with the analyte signal in the low charge-to-mass ratio region. Therefore, matrix-free substrates are of great significance for laser desorption ionization mass spectrometry. The basic design idea is to use the microstructure o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/64
CPCG01N27/64
Inventor 顾忠泽顾洪成丁海波刘慈慧
Owner SOUTHEAST UNIV