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Medicine for treating insulin resistance and preparation method and application

An insulin resistance and drug technology, applied in the application, drug combination, medical formula and other directions, can solve the problems such as the research report on the prevention and treatment of insulin resistance and the like, and achieve the effect of lowering blood sugar.

Active Publication Date: 2017-08-15
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] According to the literature search, so far, there has been no research report on the prevention and treatment of insulin resistance by Gingeria japonica

Method used

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  • Medicine for treating insulin resistance and preparation method and application
  • Medicine for treating insulin resistance and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation of Gingeria japonica extract

[0025] Take 1Kg of Zingiber officinalis medicinal material, dry it in an oven at 60°C for 24 hours, and then pulverize it. Add 1000ml of ethanol aqueous solution with a volume fraction of 70% to the pulverized medicinal materials, soak at room temperature for 2 hours, heat in a water bath to reflux, and extract by reflux for 2 hours each time, and reflux extraction for 3 times in total; collect the ethanol extract and recover the ethanol until it has no alcohol smell. Dry the crude extract, dissolve the crude extract in water to obtain an aqueous solution, extract with petroleum ether to obtain a petroleum ether layer and a water layer; extract with ethyl acetate to obtain an ethyl acetate layer and a water layer; add n-butanol for extraction, The n-butanol extract is obtained, and the n-butanol extract is subjected to solvent recovery and dried to obtain the extract of the present invention.

[0026] The crude extr...

Embodiment 2

[0027] Example 2: Experimental study on the hypoglycemic effect of the extract of Gingeria officinalis

[0028] 50 9-week-old male ob / ob mice were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., under normal feeding conditions (standard mouse feed, room temperature 23°C, humidity 70%, 12h / 12h day / night) After acclimating to the environment for 1 week, fasting for 6 hours and measuring tail vein blood glucose levels, 30 animals with fasting blood glucose above 10mmol / L were included in this study. 30 male mice were randomly divided into 5 groups, 6 animals in each group: model group, metformin group and extract high (200mg / Kg), medium (100mg / Kg) and low (50mg / Kg) dose groups, another Six wild-type C57BL / 6J mice served as the normal control group. The normal control group and the model group were given distilled water, the positive drug group was given rosiglitazone (10 mg / kg), and the extract high, middle and low dose groups were given correspond...

Embodiment 3

[0033]Example 3 The preparation example of the Gingeria japonica extract powder in the present invention

[0034] The prepared Zingiber officinalis extract was ground into fine powder and sieved, and 1 part of the sifted Chinese medicine extract fine powder was taken, 3.5 parts of starch and 6.5 parts of lactose were added and mixed evenly by the method of equal addition and mixing, The powder is prepared in divided doses according to the volumetric method.

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Abstract

The invention relates to a medicine for treating insulin resistance and a preparation method and an application. The medicine for treating insulin resistance contains a medicinal plant lauraceae litsea glutinosa extract of Lingnan. Meanwhile, the invention further discloses a preparation method of the lauraceae litsea glutinosa extract. The lauraceae litsea glutinosa extract prepared by the method has a significant effect of reducing the blood sugar, and corresponding auxiliary materials can be added to prepare multiple kinds of medicines or health products for improving insulin resistance.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for treating insulin resistance, a preparation method and an application. Background technique [0002] Insulin resistance (Insulin Resistance, IR) is a decrease in the ability of insulin to promote the body's use of glucose due to various reasons. In order to maintain normal blood sugar, pancreatic B cells compensatoryly secrete excessive insulin, which in turn causes hyperinsulinemia. Insulin resistance is the most important factor leading to the development of type 2 insulin resistance and its complications. With the change of people's lifestyle, the incidence of insulin resistance has increased significantly, and its prevention and treatment has become a public health issue of social concern. Drugs are an effective means of treating insulin resistance, but only metformin and thiazolidinediones are the only drugs that can directly improve insul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61P5/50A23L33/105
CPCA23V2002/00A61K36/54A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A23V2200/328A23V2250/21
Inventor 张小坡李友宾张彩云吴悠楠金燕
Owner HAINAN MEDICAL COLLEGE
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