A kind of high-efficiency hemostatic sponge and preparation method thereof

Abstract

The invention discloses efficient hemostatic sponge. The efficient hemostatic sponge is prepared from the following raw materials in percentage by mass: 35%-60% of chitosan, 0.1%-0.5% of thrombin, 1%-3% of polyglutamic acid, 9% of sodium chloride, 20%-35% of sodium alginate, 5%-15% of sodium hyaluronate and 1%-5% of calcium chloride. The efficient hemostatic sponge comprises a surface layer and an inner layer, wherein the surface layer is an antibacterial hemostatic layer containing chitosan, thrombin, polyglutamic acid and sodium chloride; and the inner layer is a gel layer containing sodium alginate, sodium hyaluronate and calcium chloride. The inner layer of the hemostatic sponge is in direct contact with a wound and is capable of absorbing moisture in blood to form gel to block the wound so as to realize primary hemostasis; concentrated blood penetrates through the gel layer to enter the surface layer so as to realize further hemostasis with the combined action of thrombin and chitosan; immobilized thrombin on an outer layer in the hemostatic sponge is capable of enhancing the stability, preserves efficient hemostatic activity and is unlikely to enter blood to cause a thrombus risk; and the efficient hemostatic sponge is particularly applicable to rapid hemostasis of serious bleeding caused by deep wounds, arteriorrhexis and the like.

Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and more specifically relates to a high-efficiency hemostatic sponge and a preparation method thereof. Background technique

[0002] In the hemostasis in trauma treatment of sudden accidents and clinical operations, especially in the on-site rescue of injured persons in wars, rapid and efficient hemostasis can effectively reduce casualties and alleviate later complications. Traditional hemostatic materials have unsatisfactory hemostatic effects on wounds such as irregular shapes, deep, narrow, and ruptured arteries. Therefore, there is a need for a fast, safe and efficient hemostatic material suitable for on-site and clinical first aid to replace traditional hemostatic materials.

[0003] Chitosan is a natural biological polysaccharide produced after deacetylation of chitin. It is the only alkaline polysaccharide in nature so far, and its natural resources are very rich. Due to its excellen...

Images