45 results about "Thrombotic risk" patented technology

The invention provides a multi-module collaborative clinical blood coagulation function intelligent evaluation and drug recommendation system, and relates to the technical field of medical information processing. Comprising a data acquisition and fusion module, a state recognition module, a drug intervention effect evaluation module, a decision recommendation module and a system visualization module. According to the system, continuous integration of clinical scattered data is realized by constructing a unified time sequence structure of multi-source detection indexes and medication records; generating a blood coagulation state vector containing the bleeding risk and the thrombus risk through a state recognition mechanism combining rule judgment and data calculation, outputting a confidence score and an index contribution degree, and forming a state track evolving along with time; performing causal evaluation on the difference of the state change before and after intervention to obtain a drug average treatment effect; and individualized drug suggestion or early warning information is generated based on the state track and the intervention effect. And dynamic evaluation and drug intervention measurement and calculation of the blood coagulation risk are realized.

The invention relates to a blood rheological parameter online monitoring and thrombus risk assessment method, which comprises the following steps: introducing a blood sample into a microfluidic channel with a periodic geometric mutation structure, applying unsteady shear disturbance through a piezoelectric oscillation device, inducing blood to enter a non-equilibrium rheological state, and exciting a microcosmic coagulation tendency; the red blood cell aggregation behavior, the cell layer slippage phenomenon and the plasma shearing stability are recognized through the photo-thermal interference technology, and the rheological structure layer differentiation characteristics in blood are obtained; the blood subjected to shear disturbance is guided to a micro-channel high-pressure area provided with a flow-limiting threshold structure, and pressure mutation and microcoacervation nucleation generation behaviors induced by local stress disturbance are detected through a nanoscale piezoresistive sensor so as to identify sub-phase change response characteristics of the blood; and constructing a rheological instability index system on the basis of physical response signals obtained by shear disturbance, slippage and variable response, and when linkage abnormity of any two indexes is detected, judging that a high-risk event of thrombosis occurs and outputting a risk prompt signal.

The invention discloses an integrated valvular catheter and a preparation method thereof, relates to the technical field of medical instruments, and aims to solve the problems that in a traditional valvular catheter operation, suturing is tedious, tearing and thrombus risks exist, and adaptability is insufficient. The integrated valve-containing pipeline is composed of a valve leaflet and a pipeline body which are integrated through the sintering effect, sewing is not needed, and the reflux and thrombus risks caused by sewing gaps are effectively avoided; a metal memory alloy support is embedded in the wall of the pipeline, so that support can be provided for the valved pipeline to stabilize haemodynamics and prevent the pipeline from collapsing, endovascular intervention delivery can be achieved, and the device is adaptive to a surgical opening mode or an endovascular implantation mode and is used for replacing the valved pipeline at parts such as pulmonary artery and lower limb deep vein of a human body and recovering the function of the damaged valve.

This invention discloses an intelligent control method for a catheter pump based on electrical parameters. By collecting electrical parameters such as the current, voltage, and speed of the drive motor, and applying a neural network constructed using the Matlab toolbox or written code, the output flow rate is accurately estimated, eliminating the risks of infection and thrombosis associated with traditional invasive flow detection. The nonlinear mapping capability of the neural network effectively overcomes the shortcomings of traditional indirect measurement methods in complex operating conditions due to insufficient accuracy. The model developed based on the Matlab platform has good portability and can be converted into embedded code for real-time execution on a microcontroller, reducing system cost and power consumption. Finally, through closed-loop feedback control, automatic and precise adjustment of the catheter pump flow rate is achieved, completing the technical closed loop from non-invasive sensing to intelligent control, meeting the needs of precise clinical treatment.

The application discloses a method and system for identifying abnormalities in the coagulation process based on big data analysis, comprising: combining standard coagulation detection and thromboelastography dynamic monitoring to realize the leap from static indicators to functional whole-process evaluation, while combining patient individual characteristics to screen similar historical cases, and accurately identifying key coagulation indicators; introducing correlation analysis to dynamically screen key indicators, and using clustering analysis to establish an adaptive normal range, and finally evaluating abnormalities by quantifying the degree of deviation, the application significantly improves the accuracy and timeliness of coagulation state monitoring, provides individualized early warning and intervention basis for clinical practice, effectively prevents bleeding or thrombosis risk, and promotes the intelligent and refined development of coagulation management.

The present invention provides compositions and methods for inhibiting thrombosis in subjects at risk of thrombosis, such as those with a genetic, acquired, or environmental risk of thrombosis. [Solution] The present invention provides RNAi agents, such as double-stranded RNAi agents, that target kallikrein B, plasma (Fletcher factor) 1 (KLKB1) gene, factor XII (Hageman factor (F12) gene, or kininogen 1 (KNG1) gene, as well as methods for inhibiting the expression of the KLKB1 gene, F12 gene, and / or KNG1 gene using such RNAi agents, and methods for treating subjects with hereditary angioedema (HAE) and / or contact activation pathway-related disorders.

The invention relates to the technical field of medical data processing, in particular to a children thrombus risk prediction model and an active monitoring system. The model comprises a first network used for screening an initial data set collected in real time according to names of child medical indicators in a preset first data set, and setting a time sequence mark for data with a time sequence change characteristic in the screened data to obtain the first data set; extracting a second feature from the data provided with the time sequence mark based on the time change trend of the data, and adding the second feature into the first data set; the second network is used for inputting the first data set into a plurality of first models, and the first models comprise a plurality of different path relations learned through pre-training; probability values in the path relation are obtained through a first feature learned by a first model in a pre-training stage, and a risk probability is calculated based on the multiple probability values; by introducing dynamic real-time data, the prediction model better fits the clinical logic of children's thrombus attack, and the prediction accuracy is improved.

The invention relates to the field of medical health and intelligent optimization, and discloses a dialysis anticoagulation risk intelligent early warning method and system fused with multi-modal physiological signals, and the method comprises the steps: S1, synchronously collecting the multi-modal data of a patient in the dialysis process, and standardizing the multi-modal data into a unified time sequence matrix; s2, inputting the unified time sequence matrix into an anticoagulation risk prediction model, performing first-class feature extraction on continuous monitoring signals, performing second-class feature extraction on discrete detection signals, and extracting embedding features of patient individualization and treatment scene data; performing cross-modal fusion on the three types of extracted features to generate a fusion feature vector, and outputting a thrombus risk probability and a bleeding risk probability in a future preset time period; s3, when the risk probability exceeds the corresponding early warning threshold value, performing search optimization on the administration parameter of the current anticoagulant, and generating a dose adjustment instruction; and S4, executing the adjustment instruction, predicting the anti-coagulation risk again, and evaluating the regulation and control effect. Therefore, the safety and effectiveness of the hemodialysis process are remarkably improved.

The application discloses a sports nutrition food composition for blood vessel health and post-exercise recovery. Each 40g contains soybean protein isolate, whey protein, resistant dextrin, inulin, ginkgo biloba extract, hawthorn extract, grape seed extract, sea buckthorn peptide, natto powder (containing natto kinase), coenzyme Q10, natural vitamin E, vitamin C, bacillus subtilis DE111 and mineral probiotic premix. The application realizes blood vessel cleaning and post-exercise recovery through the synergy of multiple pathways such as direct thrombolytic effect of natto kinase, anti-platelet aggregation of ginkgo biloba / hawthorn / grape seed, protection of blood vessel endothelium by coenzyme Q10 / VE / VC, and regulation of intestinal tract by bacillus subtilis DE111. In-vitro thrombolysis experiment shows that the composition has clear fibrinolytic activity. All components meet the national standard of sports nutrition food, are safe and compliant, and are suitable for people with thrombosis risk and people who need blood vessel repair after high-intensity exercise.

The invention discloses a left iliac total vein extravascular stent and an operation method, and belongs to the field of medical instruments. The stent comprises a middle section connecting sleeve frame, an inferior vena cava sleeve frame and a left iliac vein sleeve frame which are integrally formed, the included angle between the three is 135-145 degrees, an elastic silica gel limiting clamping belt is arranged and made of a silicon rubber material, and the crosslinking density and flexibility are regulated and controlled by adjusting the vinyl content. The surgical method comprises the following steps of: minimally invasive laparoscopic approach, implanting a stent after exposing a target blood vessel, and adjusting the position. Direct contact between the built-in stent and the intima is avoided, the intima hyperplasia and thrombus risks are reduced, fatigue resistance and creep resistance are achieved, the stent is attached to the anatomical structure, fixation is stable, minimally invasive recovery is fast, customizable adaptation can be achieved, and the clinical treatment effect and safety are improved.

This invention discloses a limb care device after cardiovascular interventional surgery, belonging to the field of medical auxiliary device technology. It includes a positioning unit, a compression unit, and a control unit. Through targeted structural design and collaborative control logic, it solves the contradiction between hemostasis and ischemia prevention in postoperative care, while improving nursing efficiency, stability, and safety. It uses the functional zoning of the central balloon in the puncture core area and the annular balloon in the surrounding auxiliary area, combined with the control logic that prioritizes the central balloon over the annular balloon, the annular balloon immediately stops circulation to maintain pressure when the pressure of the central balloon fluctuates. This ensures continuous hemostasis at the puncture site and avoids the risk of ischemia and thrombosis caused by long-term compression. The pressure threshold limitation, circulation reflux design, and emergency pause mechanism form multiple safety protections, reducing the risk of complications such as swelling and pain. It is also suitable for multiple puncture sites and patients of different body types, taking into account both medical and nursing efficiency and patient comfort.

The invention discloses a stent based on a full-drug-based structure function integrated composite coating and a preparation method and application thereof, and belongs to the technical field of medical instruments.The stent comprises a stent body, tannic acid coatings and EP-C9 polypeptide coatings are sequentially arranged on the outer surface of the stent body from inside to outside, the tannic acid coatings and the EP-C9 polypeptide coatings are alternately arranged, and the tannic acid coatings and the EP-C9 polypeptide coatings are sequentially arranged on the outer surface of the stent body from inside to outside. One tannic acid coating and one EP-C9 polypeptide coating are marked as one group, N groups are arranged in total, and N is greater than or equal to 1. The stent has excellent antithrombotic and anti-inflammatory functions and has no carrier residue side effect, components of the coating are functional molecules and structural molecules and are completely absorbed by a body after playing pharmacological action, and the problem that a traditional stent has inflammation and thrombus risks is fundamentally solved.

The invention discloses a chest catheter expansion stent and an expansion stent system, and belongs to the technical field of medical instruments, the chest catheter expansion stent comprises a cylindrical grid stent section and a flower-shaped stent section, the cylindrical grid stent section is used for being implanted into a chest catheter arch, and the flower-shaped stent section is used for being indwelled in veins; the flower-shaped stent section comprises hollowed-out petals arranged in the circumferential direction, and the hollowed-out petals are bent towards the far end of the cylindrical grid stent section. The dilation stent system comprises a conveying device and a chest catheter dilation stent. The near end of the thoracic duct expansion stent is in a flower shape, hollow petals are bent outwards, the thoracic duct-vein angle tissue can be attached more tightly, the contact area is increased, radial stress is dispersed, progressive supporting force is provided, stent displacement is avoided, a good anchoring effect is achieved, and the stability of the thoracic duct expansion stent is improved. The continuous injury to the intravenous intima is reduced, the thrombus risk is reduced, the elastic retraction of the chest catheter wall is effectively resisted, and the restenosis is prevented from the source of mechanical design.

The application provides a track type three-leaflet mechanical valve. The track type three-leaflet mechanical valve comprises a ring-shaped support and valve leaves, the ring-shaped support is a hollow columnar structure, the valve leaves comprise trailing edges and leading edges connected to the ring-shaped support; the valve leaves are three, the three valve leaves are sequentially and spacedly arranged along the circumference on the inner wall of the ring-shaped support, the inner wall of the ring-shaped support is provided with movement tracks matched with the valve leaves, the movement tracks accommodate and receive the leading edges of the valve leaves; the inner wall of the ring-shaped support is provided with a partition body between adjacent valve leaves, the partition body separates the valve leaves and supports the end portions of the valve leaves. The application optimizes the structure, improves the fluid dynamics performance, reduces the interference to blood flow, optimizes the blood flow performance, enhances self-cleaning, and reduces the thrombosis risk.

Methods of reducing the risk of venous thromboembolism (VTE) in a subject undergoing anticoagulant treatment by selectively depleting Factor V Leiden (FVL) in a subject that is heterozygous for FVL, or replacing FVL in the genome of a subject that is homozygous for FVL with a functional Factor V gene, and methods of identifying a subject undergoing anticoagulant treatment who is at risk of developing VTE are disclosed herein.

The utility model provides an anti-skidding back cushion for adjusting an intraoperative body position, which belongs to the technical field of the intraoperative body position back cushion and comprises a support component with an inclined plane design, a magic tape hook claw arranged at the bottom of the support component and a polyurethane coating coated on the surface of the support component, the supporting assembly comprises a supporting part, shoulder supports located on the two sides of the top of the supporting part, an arc-shaped groove located between the two shoulder supports and a supporting inclined face located at the front end of the supporting part. By means of the supporting assembly with the inclined face design, the situation that a patient slides down in the operation can be prevented, the head posture adjusting function is achieved, the head is kept in a slightly-raised posture all the time, and the thrombus risk in the operation can be reduced; the polyurethane coating can increase friction force between a patient and the surface of the back cushion, the shoulder supports and the arc-shaped grooves provide stable shoulder and head support, blood circulation is optimized, and therefore safe and comfortable body position support is provided for the patient in a complex operation environment.

This invention discloses a home-based intelligent monitoring and rehabilitation training system, method, terminal, and medium for arteriovenous fistulas (AVFs), relating to the field of smart medical technology. The system includes: home-based devices, a cloud server, and a software interactive management platform. The home-based devices include an AVF monitoring wristband and an intelligent arm exerciser. The AVF monitoring wristband collects AVF blood flow acoustic signature data and provides early warnings to the patient. The intelligent arm exerciser collects motion parameters and provides rehabilitation training and movement guidance functions for the patient. The cloud server processes the collected AVF blood flow acoustic signature data and motion parameters, performs thrombosis risk analysis, and generates a rehabilitation training plan. The software interactive management platform allows real-time viewing of the patient's AVF status, rehabilitation training plan, and exercise records. This invention fills the gap in integrated home-based AVF monitoring, early warning, rehabilitation training, and feedback, providing an intelligent solution for reducing AVF failure rate and extending AVF lifespan.

The application relates to the technical field of nerve electrophysiological monitoring, and discloses an intravascular brain electrode. The electrode comprises a flexible net-shaped support adopting an M-shaped weaving structure, a micro recording point independently arranged at a node of the support, and a flexible wire system. The support has a zero axial shortening characteristic and generates a mild radial supporting force after expansion; and the recording point has a directional collection structure for blocking blood shunt. The application realizes mechanical decoupling through M-shaped structure and node fixation, eliminates motion artifacts, improves the signal-to-noise ratio by using directional collection, and reduces the risk of thrombosis by cooperating with a high open hole rate, so that the technical problems of "uncertain measurement", "incomplete measurement" and "insecurity" are solved in one station.

The application belongs to the technical field of medical decision support, and discloses a knee joint postoperative distal deep vein thrombosis prediction system; by acquiring multi-dimensional parameters such as coagulation function, metabolic function, inflammation ratio index and intra-articular injection history, the sodium hyaluronate injection history is converted into an articular lesion severity score, an inflammation-coagulation coupling characteristic vector and a metabolic disturbance correction model are innovatively constructed, and the synergistic effect among multiple systems is captured. A penalty regression model with cross-validation is used for sparse prediction factor screening, redundant variables are screened out through a regularization path shrinkage technology, and key prediction factors are reserved. Finally, an individualized thrombosis risk probability nomogram is constructed, and the prediction accuracy is verified through resampling calibration. The application realizes the multi-system integration of inflammation, coagulation, metabolism and joint degeneration factors, converts the complex statistical model into a clinically friendly tool, and optimizes the postoperative thrombosis prevention and control strategy.

The invention provides a thrombus prevention intelligent equipment linkage monitoring quality control method and system based on the Internet of Things, and relates to the technical field of the Internet of Things, and the method comprises the steps: obtaining the physiological state data of a target monitoring object, carrying out the analysis processing of the data based on a preset thrombus risk assessment model, and determining the thrombus risk level. The model is established according to an association relationship between limb activity state data and blood circulation state data; matching a corresponding equipment linkage control strategy from a preset equipment control strategy library according to the thrombus risk level; according to a cooperative control relationship defined in the strategy, generating a linkage control instruction sequence for the plurality of Internet of Things devices; and finally, distributing the instruction sequence to a plurality of Internet of Things devices, and driving the devices to execute thrombus prevention intervention operation according to the time sequence dependency relationship and the execution condition constraint relationship. According to the intelligent thrombus prevention and monitoring system, intelligent thrombus prevention and monitoring of multi-device cooperative linkage are realized, and the accuracy and timeliness of prevention and intervention are improved.

The invention provides a left atrial appendage typing and risk assessment method and system based on a medical image. The method comprises the following steps: acquiring three-dimensional medical image data; carrying out preprocessing and registration on the multi-modal image; automatically segmenting a left atrial appendage and positioning an opening plane based on a deep neural network; extracting and fusing anatomical, dynamic and textural features to form a standardized feature vector; performing four types of standardized typing on the left atrial appendage by using the training model, calculating an individualized thrombus risk by combining the typing probability, the image features and the clinical score, and outputting a risk level; and finally realizing three-dimensional visualization and generating a structured report. The system comprises an image acquisition module, a preprocessing and registration module, a segmentation and positioning module, a feature extraction and fusion module, a typing module, a risk assessment module and a visualization and report module, and all the modules cooperate in sequence to complete the method. The method realizes automation and objectification of left atrial appendage typing and risk assessment, and has the advantages of high accuracy, strong repeatability and high clinical application value.

The invention discloses a portable thrombus risk monitor and a using method thereof, and relates to the field of medical detection.The portable thrombus risk monitor comprises a protective shell, a protective cover is hinged to the top of the protective shell, monitoring equipment is connected into the protective shell, an operation key is connected to the upper surface of the monitoring equipment, and a handle is connected to the side face of the protective shell; and an upper push block and a guide block are symmetrically and slidably connected to the bottom of the monitoring equipment, the upper push block and the guide block both penetrate through the inner side of the monitoring equipment in a sliding mode, and the guide block is fixed to the inner side of the protective shell. According to the portable thrombus risk monitor and the use method thereof, when the portable thrombus risk monitor is used, a top protective cover is opened through a hinge, the top protective cover drives a bottom connecting belt to move, then a rotating block is driven to rotate, a coil spring is tightened, the connecting belt extends along a guide wheel, the rotating block drives a bevel gear to be meshed, and a back-and-forth convex column is promoted to rotate and extrude an extrusion block; when the extrusion block is extruded, the upper push block and the monitoring equipment can be pushed to move upwards, the monitoring equipment can be used without being taken out after moving upwards, and operation is convenient.

The utility model discloses a kind of vascular surgery medical care wrist strap, including wrist strap body, the both ends of wrist strap body are detachably connected, the center of wrist strap body is detachably connected with blood flow monitoring component, the blood flow monitoring component includes at least 2 PPG sensors and pressure buffer pad of symmetrical distribution, the pressure buffer pad is arranged at the bottom end of PPG sensor, the PPG sensor is adhered to skin by pressure buffer pad by buffer pad but does not compress blood vessel. The utility model is combined with wrist strap body, at least 2 PPG sensors and pressure buffer pad and the like structure of symmetrical distribution, avoid the compression of traditional finger clamp type probe to blood vessel, ensure that blood flow signal is real and reliable, and the detection of the above-mentioned blood flow signal can help medical staff to judge whether patient has thrombosis risk in time. The structure of pressure buffer pad is arranged, can avoid PPG sensor to compress patient skin when using, increase the comfort degree of medical care wrist strap in long-term wearing process.

The application discloses a platelet detection kit based on multi-parameter flow cytometry and a use method thereof, relates to the technical field of in-vitro diagnosis, and covers the core pathological links of thrombosis and downstream key events of thrombosis by simultaneously detecting the proportion of PNH clone cells, the platelet activation state and the proportion of platelet-leukocyte aggregates (PLAs), thereby efficiently and accurately evaluating the thrombosis risk of PNH patients. The application directly detects cell surface markers and cell-cell interaction by using multi-color flow cytometry, can early and sensitively identify abnormal activation signals, and avoids the limitations of traditional coagulation indexes (such as D-dimer) in PNH thrombosis early warning.

The invention relates to the technical field of intrauterine adhesion treatment, and discloses a traditional Chinese medicine composition for treating intrauterine adhesion, an enema and application, and the traditional Chinese medicine composition is prepared from the following raw materials: sargentgloryvine stem, patrinia, honeysuckle stem, fructus forsythiae, vinegar-processed rhizoma sparganii, curcuma zedoary, cortex moutan, radix paeoniae rubra, spina gleditsiae, selfheal, beautiful sweetgum fruit, folium artemisiae argyi, oldenlandia diffusa, honeysuckle, coix seed and peach kernel. A pure traditional Chinese medicine formula is used for replacing large-dose estrogen for adjuvant therapy, so that hormone-related side effects (such as endocrine disorder, thrombus risk and the like) are avoided, adhesion and relapse are reduced through the overall conditioning effect of traditional Chinese medicines, and the clinical problems of'unstable curative effect and easiness in relapse 'in traditional therapy are solved; and a safer and long-acting choice is provided for intrauterine adhesion treatment.

The utility model discloses a safe blood sampling type indwelling needle, which relates to the technical field of medical instruments, and comprises a blood sampling block and an indwelling block, a needle handle is obliquely provided with an indwelling interface, the indwelling interface is connected with an indwelling hose, the needle handle is provided with a main body part and a shell which are movable end to end, and the side surface of the main body part is provided with an elastic buckle structure for limiting. The side face of the shell extends to form an inverted buckle block matched with the buckle structure, the variable-diameter sleeve is arranged outside the puncture needle tube in a sleeving mode and connected to the shell, a sealing interlayer is arranged above the indwelling connector in the shell, and the puncture needle tube and the sealing interlayer are tightly arranged. The technical problem to be solved by the utility model is to provide the safe blood sampling type indwelling needle, a channel in a blood sampling function cannot be communicated with an infusion channel of the indwelling needle, the thrombus risk after blood flows to an infusion pipeline is reduced, the puncture risk and the blood splashing risk caused by tube replacement in the blood sampling process of medical personnel are reduced, and the safety of the medical personnel is improved. And the buckle structure forms safe path limiting, so that the safety is improved.

This invention belongs to the field of thrombosis risk prediction technology, and relates to a method and system for thrombosis risk prediction based on the coupling of drinking water and exercise data. This invention integrates wearable devices and intelligent sensing devices to collect real-time temporal data of the user's lower limb movement and water intake, and combines this with individual physiological parameters to construct a personalized physiological dynamic model. This personalized physiological dynamic model dynamically simulates continuous changes in blood viscosity, lower limb blood flow velocity, and blood retention, generating a risk prediction trajectory for future time periods. When the risk exceeds a threshold, multiple intervention strategy packages are tested in a virtual environment to evaluate their impact on physiological state, and a preferred intervention strategy package that balances risk elimination effectiveness and execution cost index is selected based on a multi-objective optimization algorithm. Finally, personalized risk control guidance information containing the preferred intervention strategy is output, effectively improving the timeliness and personalization of thrombosis prevention.

The invention discloses a home internal arteriovenous fistula intelligent monitoring and rehabilitation training system and method, a terminal and a medium, and relates to the technical field of smart medicine, the system comprises a home device, a cloud server and a software interaction management platform; the home equipment comprises an internal fistula monitoring bracelet and an intelligent arm exerciser; the internal fistula monitoring bracelet is used for collecting internal fistula blood flow voiceprint data and giving an early warning prompt to a patient; the intelligent arm exerciser is used for collecting motion parameters and providing a rehabilitation training function and an action guiding function for a patient; the cloud server is used for processing the collected internal fistula blood flow voiceprint data and motion parameters, performing thrombus risk analysis and generating a rehabilitation training scheme; the software interaction management platform is used for checking the internal fistula condition, the rehabilitation training scheme and the exercise record of the patient in real time. According to the invention, the integrated blank of home internal fistula monitoring, early warning, rehabilitation training and feedback can be filled up, and an intelligent solution is provided for reducing the power loss of internal fistula and prolonging the service life of internal fistula.

This invention discloses a three-dimensional MoBT x @CuS heterostructure nanocomposite wound repair material, its preparation method and application, relating to the field of biomedical materials. The preparation method includes the following steps: S1, preparing MoBT by alkaline etching. x MBene nanosheets; S2, MoBT x MBene nanosheets were dispersed in water, and a copper source, surfactant, and reducing agent were added to adjust the pH. A sulfur source was then added, and the reaction proceeded. After solid-liquid separation, washing, and drying, MoBT was obtained. x @CuS; S3, MoBT x @CuS reacts with a borate esterification reagent to yield borate-esterified MoBT. x @CuS, by grafting zwitterionic polymers onto its surface, yields MoBT. x @CuS heterojunction nanocomposite materials. This invention can solve the problem of reactive oxygen species imbalance in existing acoustic dynamic materials and MoBT. x The material poses a risk of thrombosis. Achieving a synergistic balance between antibacterial, anti-inflammatory, and biosafety properties allows it to be used to prepare wound repair drugs against drug-resistant bacterial infections.

This invention discloses an exercise device for preventing lower limb thrombosis in heart failure, comprising a support plate, a lower limb fixation part, and a foot movement part. A vibrating part is installed inside the support plate, including a support plate that is raised and lowered within the support plate and a vibration motor that drives the support plate to vibrate. The lower limb fixation part is located on top of the support plate and includes an arc-shaped plate fixed to the top of the support plate. Multiple first airbags are equidistantly fixed inside the arc-shaped plate for segmented independent compression massage. The foot movement part is located at one end of the support plate and includes a foot fixing box for fixing the foot. A driving part is installed at the bottom of the foot fixing box for driving the foot fixing box to swing back and forth and left and right. In summary, this invention has the advantages of deep massage effect, promoting blood circulation, reducing the risk of thrombosis, reliable fixation, diverse exercise methods, and promoting lower limb blood circulation.