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Carbamido pyrimidone modified gelatin injectable self-healing hydrogel and preparation method thereof

A ureidopyrimidinone and hydrogel technology, which can be used in pharmaceutical formulations, non-active components of polymer compounds, medical science, etc., can solve problems such as few injectable hydrogels, and achieve easy large-scale production and practical application. , The raw materials are cheap and easy to obtain, and the self-healing performance is good.

Inactive Publication Date: 2017-08-15
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fe 3+ Although ionic interactions with carboxyl groups have been used to prepare high-strength hydrogels, there are few reports on the preparation of injectable hydrogels

Method used

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  • Carbamido pyrimidone modified gelatin injectable self-healing hydrogel and preparation method thereof
  • Carbamido pyrimidone modified gelatin injectable self-healing hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation of ureidopyrimidinone modified gelatin injectable self-healing hydrogel, comprising the steps of:

[0038] (1) Dissolve 2.0 g of gelatin in 40 mL of dimethyl sulfoxide (DMSO) under heating and stirring at 50°C. After the gelatin is completely dissolved, stop heating, cool the solution to room temperature, and weigh 0.1 g of 2 -(6-isocyanate hexylamine amide)-6-methyl-4-[H]-pyrimidinone (UPy-NCO) (5% of the gelatin mass) was added to the solution, stirred and reacted at room temperature for 12 hours;

[0039] (2) Add the reaction solution dropwise to 8 times the amount (volume ratio) of absolute ethanol to precipitate the polymer, and filter under reduced pressure to obtain UPy modified gelatin (Gelatin-UPy); dissolve Gelatin-UPy Dialyze in 20 mL deionized water and add 1000 mL deionized water for 3 days (change the water every other day) to remove the solvent DMSO; after the dialysis is completed, put the dialyzed polymer solution in a refrigerator at -18°...

Embodiment 2

[0044] A preparation of ureidopyrimidinone modified gelatin injectable self-healing hydrogel, comprising the steps of:

[0045] (1) Dissolve 4.0 g of gelatin in 50 mL of DMSO under heating and stirring at 60°C. After the gelatin is completely dissolved, stop heating, cool the solution to room temperature, and weigh 0.3 g of UPy-NCO (7.5% of the gelatin mass). %) was added to the solution, stirred and reacted at room temperature for 8 hours;

[0046] (2) Add the reaction solution dropwise to 8 times the amount (volume ratio) of absolute ethanol to precipitate the polymer, and filter under reduced pressure to obtain the modified polymer Gelatin-UPy. Dissolve Gelatin-UPy in 20 mL of deionized water, and add 1000 mL of deionized water for dialysis for 5 days (change the water every other day), and remove the solvent DMSO; Hour, then vacuum drying obtains pure polymer Gelatin-UPy for 36 hours;

[0047] (3) Dissolve the pure polymer Gelatin-UPy in deionized water at 40°C to prepar...

Embodiment 3

[0050] A preparation of ureidopyrimidinone modified gelatin injectable self-healing hydrogel, comprising the steps of:

[0051] (1) Dissolve 4.0 g of gelatin in 60 mL of DMSO under heating and stirring at 50 °C. After the gelatin is completely dissolved, stop heating, cool the solution to room temperature, and weigh 0.2 g of UPy-NCO (5% of the gelatin mass). %) was added to the solution, stirred and reacted at room temperature for 12 hours;

[0052] (2) Add the reaction solution dropwise to 8 times the amount (volume ratio) of absolute ethanol to precipitate the polymer, and filter under reduced pressure to obtain the modified polymer Gelatin-UPy. Dissolve Gelatin-UPy in 40 mL of deionized water, and add 1000 mL of deionized water for dialysis for 6 days (change the water every other day), and remove the solvent DMSO; Hour, then vacuum drying obtains pure polymer Gelatin-UPy for 36 hours;

[0053] (3) Dissolve the pure polymer Gelatin-UPy in deionized water at 37°C to prepar...

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Abstract

The invention discloses a carbamido pyrimidone modified gelatin injectable self-healing hydrogel and a preparation method thereof. The method comprises the following steps: by taking gelatin as a main chain of a hydrogel polymer, introducing nucleophilic reaction into a side chain and acquiring UPy modified gelatin through quadrupolar hydrogen bond crosslinked carbamido pyrimidone (UPy); and meanwhile, adding ferric ion into the prepared UPy modified gelatin and forming ionic crosslinking, on the basis of a large amount of carboxylic acid groups of the main chain of the gelatin, thereby preparing a multiple hydrogen bond ion interacting double-physical cross-linking hydrogel. The preparation method disclosed by the invention has the advantages of low-cost easily acquired raw materials, simple process, mild preparation condition, low cost and equipment requirements, easiness in scale production and practical application and excellent application prospect. The prepared double-physical cross-linking hydrogel has an excellent self-repairing property and is injectable.

Description

technical field [0001] The invention belongs to the field of injectable hydrogels, in particular to a ureidopyrimidinone-based modified gelatin hydrogel and a preparation method thereof. Background technique [0002] Due to its unique physical cross-linking method, injectable hydrogels maintain a series of basic properties of traditional hydrogels, and have injectability, shear thinning, and in-situ gels that traditional hydrogels do not have. Therefore, it has a very broad application prospect in the fields of drug delivery, tissue repair, and biosensing. However, the traditional covalent bond cross-linked hydrogel usually uses toxic catalysts and cross-linking monomers in the preparation process, which will cause damage to biological tissues, cells, and drugs, thus limiting its application in the biological field. In addition, due to the irreversibility of covalent bonds, covalently bonded hydrogels are difficult to inject and gel in situ, which is difficult to meet the n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08K3/16C08H1/00A61L27/52A61L27/50A61L27/22A61K47/42C08L89/00
CPCC08J3/075A61K47/42A61L27/222A61L27/50A61L27/52A61L2400/06C08H1/00C08J3/24C08J2389/00C08K3/16C08L89/00
Inventor 王朝阳张光照
Owner SOUTH CHINA UNIV OF TECH
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