Method for preparing etoricoxib crystal form V

Abstract

The invention discloses a method for preparing an etoricoxib crystal form V. The method comprises the steps that etoricoxib is dissolved in an appropriate solvent, little acid is added to induce crystallization, and filtering and drying are performed to obtain the etoricoxib crystal form V. The method is simple in operation, good in reproducibility, high in yield and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and specifically relates to a method for preparing etoricoxib crystal form V, a pharmaceutical composition and a medical application. Background technique [0002] Etoricoxib is a selective inhibitor of cyclooxygenase-2, which has anti-inflammatory, antipyretic and analgesic effects. Its chemical structure is as follows. [0003] [0004] At present, the film-coated tablets of etoricoxib have been marketed in many countries such as the United Kingdom, Spain, Australia, and China, and are mainly used as non-steroidal anti-inflammatory drugs in clinical practice. [0005] The crystal form of etoricoxib has a great influence on the properties of the drug. Patent WO2001092230A1 discloses the properties and preparation methods of eight crystal forms of etoricoxib, including crystal form I, crystal form II, crystal form III, crystal form IV, Form V, hemihydrate, sesquihydrate and amorphous state,...

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Problems solved by technology

However, there is no mention of the preparation method of crystal form V

[0008] The above-mentioned existing literature has carried out many studies on the crystal form of etoricoxib, but there are few references to the preparation of the crystal form V that can be used in pharmaceutical preparations. Only WO2001092230A1 discloses a very simple method, and after the inventor's efforts It is difficult to reproduce the crystal form V after many attempts

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