A dropper solid-phase extraction device and method and the preparation method of the device

Abstract

The invention discloses a dropper solid phase extraction device which comprises a power device and a solid phase extraction container. The dropper solid phase extraction device is applied to a non-aqueous medium solid phase extraction and the solid phase extraction container is made from glass. A solvent held in the solid phase extraction container is a non-polar or weakly polar solvent; the power device is arranged above the solid phase extraction container, and solid phase extraction in the solid phase extraction container is realized by squeezing the power device. The invention also comprises a dropper solid phase extraction method and a preparation method and application of the dropper solid phase extraction device. By taking the glass container as the dropper solid phase extraction container, interference of a plasticizer during non-aqueous medium extraction in a conventional plastic container is effectively avoided.

Description

technical field

[0001] The invention relates to the technical field of sample pretreatment, in particular to a dropper solid-phase extraction device and method and a preparation method of the device. Background technique

[0002] Miniaturized solid-phase extraction technologies, such as tip solid-phase extraction and syringe solid-phase extraction, have the characteristics of simple operation, fast speed, and small sample volume, and have good application prospects in the field of sample pretreatment. However, most of the existing miniaturized solid-phase extraction devices use plastic products such as tips and syringes as extraction device containers. Organic solvents used in extraction experiments tend to dissolve plasticizers and other substances from the plastic surface into the extraction system, which interferes with analysis and testing. For example, experiments have shown that the use of plastic products when extracting acidic substances in crude oil will introduce a...

Examples

Embodiment 1

[0035] Please refer to figure 1 , the embodiment of the present invention provides a kind of burette solid phase extraction device, comprises power unit 4 and solid phase extraction container 10, and described burette solid phase extraction device is applied to non-aqueous medium solid phase extraction, and described solid phase extraction The manufacturing material of container 10 is glass, and the solvent contained in described solid-phase extraction container 10 is non-polar or weakly polar solvent, and described power unit 4 is arranged on the top of solid-phase extraction container 10, by extruding power unit 4 The solid phase extraction in the solid phase extraction container 10 is realized. The device uses glass as the material for the solid-phase extraction container 10, so that the device can effectively avoid the interference of the plasticizer during the extraction of the non-aqueous medium during the solid-phase extraction process. For example, when the sample is a...

Embodiment 2

[0052] The difference between this embodiment and embodiment 1 is that the length of the first connecting pipe 1 is preferably 4 cm, the length of the second connecting pipe 2 is preferably 8 cm, the amount of the particle adsorbent is 20 mg, and the cotton The dosage is 2mg. The rest are basically the same as in Example 1.

Embodiment 3

[0054] The difference between this embodiment and embodiment 1 is that the length of the first connecting pipe 1 is preferably 7cm, the length of the second connecting pipe 2 is preferably 18cm, the amount of the fiber adsorbent is 20mg, and the cotton The dosage is 4mg. The rest are basically the same as in Example 1.

[0055] 10 μL of silanization derivatization reagent (N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide, MTBSTFA) was added to the desorption solution obtained above, shaken at room temperature for 5 min, and then analyzed by gas chromatography-mass spectrometry.

[0056] image 3 It is a comparison chart of the extraction efficiency of the filler in the filler layer 31 in the present invention is an amino silica gel dropper and a cotton functionalized dropper. The results show that the extraction effect of the present invention is obviously better, and this is because the effective site for adsorbing petroleum acid on the surface of amino silica gel is mu...

technical field

[0001] The invention relates to the technical field of sample pretreatment, in particular to a dropper solid-phase extraction device and method and a preparation method of the device. Background technique

[0002] Miniaturized solid-phase extraction technologies, such as tip solid-phase extraction and syringe solid-phase extraction, have the characteristics of simple operation, fast speed, and small sample volume, and have good application prospects in the field of sample pretreatment. However, most of the existing miniaturized solid-phase extraction devices use plastic products such as tips and syringes as extraction device containers. Organic solvents used in extraction experiments tend to dissolve plasticizers and other substances from the plastic surface into the extraction system, which interferes with analysis and testing. For example, experiments have shown that the use of plastic products when extracting acidic substances in crude oil will introduce a...

Examples

Embodiment 1

[0035] Please refer to figure 1 , the embodiment of the present invention provides a kind of burette solid phase extraction device, comprises power unit 4 and solid phase extraction container 10, and described burette solid phase extraction device is applied to non-aqueous medium solid phase extraction, and described solid phase extraction The manufacturing material of container 10 is glass, and the solvent contained in described solid-phase extraction container 10 is non-polar or weakly polar solvent, and described power unit 4 is arranged on the top of solid-phase extraction container 10, by extruding power unit 4 The solid phase extraction in the solid phase extraction container 10 is realized. The device uses glass as the material for the solid-phase extraction container 10, so that the device can effectively avoid the interference of the plasticizer during the extraction of the non-aqueous medium during the solid-phase extraction process. For example, when the sample is a...

Embodiment 2

[0052] The difference between this embodiment and embodiment 1 is that the length of the first connecting pipe 1 is preferably 4 cm, the length of the second connecting pipe 2 is preferably 8 cm, the amount of the particle adsorbent is 20 mg, and the cotton The dosage is 2mg. The rest are basically the same as in Example 1.

Embodiment 3

[0054] The difference between this embodiment and embodiment 1 is that the length of the first connecting pipe 1 is preferably 7cm, the length of the second connecting pipe 2 is preferably 18cm, the amount of the fiber adsorbent is 20mg, and the cotton The dosage is 4mg. The rest are basically the same as in Example 1.

[0055] 10 μL of silanization derivatization reagent (N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide, MTBSTFA) was added to the desorption solution obtained above, shaken at room temperature for 5 min, and then analyzed by gas chromatography-mass spectrometry.

[0056] image 3 It is a comparison chart of the extraction efficiency of the filler in the filler layer 31 in the present invention is an amino silica gel dropper and a cotton functionalized dropper. The results show that the extraction effect of the present invention is obviously better, and this is because the effective site for adsorbing petroleum acid on the surface of amino silica gel is mu...

Images