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Sodium gualenate composition, oral-care product and preparation method thereof

A technology of sodium azulene sulfonate and oral products, applied in the field of dental preparations, can solve the problems of irritation, no oral composition, poor taste of oral products and the like

Inactive Publication Date: 2017-08-29
CHONGQING DENCARE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of zinc citrate alone in the oral cavity can cause problems such as poor mouthfeel, sourness, irritation, etc.
[0009] Although sodium azulene sulfonate and zinc citrate are commonly used raw materials in toothpaste, there is currently no oral composition combining sodium azulene sulfonate and zinc citrate. The combination ratio of sodium and zinc citrate has been studied, and it has achieved the effect of preventing and treating oral ulcers and gingivitis, and improving the taste of oral products

Method used

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  • Sodium gualenate composition, oral-care product and preparation method thereof
  • Sodium gualenate composition, oral-care product and preparation method thereof
  • Sodium gualenate composition, oral-care product and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] In the first step, add 10g of moisturizing agent glycerin, then add 0.7g of binder sodium carboxymethylcellulose, stir quickly and homogenize, then add 35g of sweetener sorbitol, 0.4g of sodium saccharin, and 0.001g of sodium azulenesulfonate , zinc citrate 0.01g, surfactant sodium lauryl sulfate 2g, antiseptic sodium benzoate 0.3g, and stir evenly;

[0039] In the second step, vacuumize and add 24 g of friction agent silicon dioxide, stir and homogenize;

[0040] In the third step, add 1g of mint essence, stir and homogenize, degas, and the toothpaste is finished.

[0041] Except for the differences in Table 1 and Table 2, the preparation methods of Example 2 to Example 7 and Comparative Example 1 to Comparative Example 7 are the same.

[0042] Experiment 1: Antibacterial test

[0043] Candida albicans (C.a) can cause thrush, oral ulcer etc., Porphyromonas gingivalis (P.g) is the main bacterium that causes periodontitis, utilizes the embodiment 1~implementation of ev...

Embodiment 8

[0064] Now with the embodiment 8 of a kind of azulene sulfonate sodium composition mouthwash of the present invention, illustrate the preparation method of the present invention:

[0065] The preparation steps are:

[0066] Step 1: First mix 5.5g of moisturizing agent glycerin, 79.289g of water, and 0.2g of sweetener neotame to form a water phase.

[0067] Step 2: Add 0.001g of sodium azulene sulfonate, 0.01g of zinc citrate, 1g of mint essence, 12g of sorbitol, and 2g of poloxamer to mix until there is no turbidity, then slowly add the water phase during stirring, and filter Dispensing, mouthwash preparation is complete.

[0068] Experiment 1: Antibacterial test

[0069] Select Candida albicans and Porphyromonas gingivalis to carry out antibacterial experiment to the mouthwash of embodiment 8~embodiment 14, comparative example 8~comparative example 12 of table 6, table 7, experimental method is according to " technical specification for disinfection " 2.1 .8.2 Carry out th...

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Abstract

The invention discloses a sodium gualenate composition. The sodium gualenate composition is mainly prepared from the following raw materials including sodium gualenate and zinc citrate; the sodium gualenate composition is prepared from the raw materials in parts by mass: 0.001 to 3 parts of the sodium gualenate and 0.01 to 8 parts of the zinc citrate. Aiming at solving the technical problems, the invention provides the sodium gualenate composition with optimal bacteriostatic and desensitizing effects, an oral-care product and a preparation method thereof.

Description

technical field [0001] The invention relates to the technical field of dental preparations, in particular to a sodium azulene sulfonate composition, an oral product and a preparation method thereof. Background technique [0002] Swollen gums, oral ulcers, and painful tongue erosions are often referred to as symptoms of oral "burning". The occurrence of oral ulcers is the result of a combination of factors, including local trauma, mental stress, food, drugs, malnutrition, changes in hormone levels, and vitamin or trace element deficiency. Among them, systemic diseases, heredity, immunity and microorganisms The occurrence and development of oral ulcers may play an important role, such as lack of trace elements zinc, iron, folic acid, vitamin B12, and malnutrition, which can reduce immune function and increase the possibility of oral ulcers; streptococcus, Helicobacter pylori, Candida albicans, etc. are also closely related to oral ulcers. [0003] Gingivitis refers to the ac...

Claims

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Application Information

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IPC IPC(8): A61K8/46A61K8/365A61Q11/00A61P1/02
CPCA61K8/466A61K8/365A61Q11/00
Inventor 田政肖博文郑伟张环蒋玮邓嵘
Owner CHONGQING DENCARE CORP
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