Ceramide liposome and application thereof to preparation of intelligent moisturizing cosmetic

A technology of ceramide lipid and ceramide, which is applied to ceramide liposome and its application field in the preparation of cosmetics, can solve the problems of low solubility of ceramide, poor physical stability, uneven moisturizing, etc., and achieves improvement of skin moisture content , small particle size, good drug loading effect

Active Publication Date: 2017-09-01
HUNAN YUJIA COSMETICS MFG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubility of ceramide in oil is very low, even if it is made into liposomes, there will be problems of low drug loading, large particle size, and poor physical stability
[0005] In addition, moisturizing ingredients are considered in the development of traditional cosmetic formulations to ensure that the product has moisturizing effect, but the skin characteristics of oily skin, dry skin, and combination skin are rarely considered in the development of moisturizing cosmetics, especially for dry skin, mixed skin For sensitive skin, there is a difference in skin moisture content between the T zone and the U zone of the face. The same moisturizing ingredients often cannot be used for special care for particularly dry areas, such as cheeks and eyes, and uneven moisturizing often occurs.

Method used

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  • Ceramide liposome and application thereof to preparation of intelligent moisturizing cosmetic
  • Ceramide liposome and application thereof to preparation of intelligent moisturizing cosmetic
  • Ceramide liposome and application thereof to preparation of intelligent moisturizing cosmetic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0064] The preparation of embodiment 1~3 liposome

[0065] The formula is shown in Table 1

[0066] Table 1 Embodiment 1~3 formula

[0067]

[0068] For the oil phase, weigh ceramide, MCT oil and candelilla wax according to the ratio, heat to 90°C to completely melt the oil, and then stir evenly. The temperature of the oil phase was maintained at 90°C.

[0069] Weigh palmitoyl hydroxypropyltrimethylammonium pullulan / glycerol crosslinked polymer, quaternized honey, chitosan, Tween-60, glycerin and water according to the ratio, and heat to 90 ℃ Make palmitoyl hydroxypropyltrimethylammonium pullulan / glycerol cross-linked polymer, quaternized honey, chitosan, Tween-60 completely dispersed in water. The temperature of the aqueous phase was maintained at 90°C and the amount of water lost was made up before emulsification.

[0070] The temperature of the oil phase was maintained at 90°C, the water phase at 90°C was put into the oil phase, the temperature was maintained at 90°C...

Embodiment 4～6

[0075] The preparation of embodiment 4~6 cosmetics

[0076] The formula is shown in Table 2

[0077] Table 2 Embodiment 4~6 formula

[0078] components Example 4 Example 5 Example 6 glycerin 3g 1g 20g Propylene Glycol 3g 1g 5g Butanediol 5g 1g 10g amino acid 1g 0.05g 5g Trehalose 0.5g 0.5g 0.5g hyaluronic acid 0.01g 0.01g 1g Betaine 2g 0.01g 5g Allantoin 0.1g 0.01g 1g Adenosine 0.5g 0.1g 2g Ceramide (Catiosphere) 0.5g (embodiment 1) 0.1g (embodiment 2) 3g (Example 3)

[0079] 1. Weigh glycerin, propylene glycol, butylene glycol, amino acids, betaine, allantoin, and hyaluronic acid according to the formula, add 0.1 g of Carbopol 940, and 0.1 g of arginine;

[0080] 2. Add deionized water to 99mL, raise the temperature to 80-85°C, stir at 180-200rpm, and stir for 30min.

[0081] 3. Cool down to 45 degrees Celsius, add adenosine, ceramide (Katiocarrier), 1g preservative PHL, s...

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Abstract

The invention relates to the technical field of cosmetics, in particular to a moisturizing composition and application thereof to preparation of a cosmetic. The ceramide is prepared into a liposome, and the prepared liposome has a relatively small particle size and high drug loading capacity; and the surface of the liposome is positively charged, and the liposome can recognize dry skin and enrich and release a moisturizing component at a dry position. The liposome is prepared into the moisturizing composition, and the composition can increase the moisture content of the skin and has the effect of reducing the moisture loss of the skin. Experiments show that the composition provided by the invention can increase the moisture content of the skin to 176.69%, and 2 h later, the moisture content of the skin can maintain an increase being higher than 96.78%.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to ceramide liposomes and their application in the preparation of cosmetics. Background technique [0002] The quality of the skin's moisturizing ability can reflect whether the skin barrier function is normal or not. The reduction of skin moisturizing ability leads to the decrease of skin barrier function, and the decrease of skin barrier function further reduces skin moisturizing ability, resulting in a vicious circle. Therefore, moisturizing is the basis and key of skin care. The decline of skin moisturizing function will lead to a variety of skin problems. It is the bottom layer of the skin care pyramid and the foundation of skin care. When the skin lacks water, cell metabolism and information transmission are affected, and even obstacles appear. The physiological structure of the skin changes such as dryness, roughness, loss of luster, reduced elasticity, increased or deepen...

Claims

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Application Information

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IPC IPC(8): A61K8/68A61K8/14A61K8/92A61K8/37A61K8/34A61Q19/00A61Q19/10
CPCA61K8/14A61K8/345A61K8/37A61K8/68A61K8/922A61K2800/10A61K2800/412A61K2800/5922A61Q19/00A61Q19/004A61Q19/10
Inventor 戴跃锋康文术何广文颜少慰
Owner HUNAN YUJIA COSMETICS MFG CO LTD
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