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Adsorption resin and its modification method after secondary crosslinking, hemoperfusion device

A technology of secondary cross-linking and adsorption resin, which is applied in the field of biomedical adsorption materials to achieve the effects of improved hydrophilicity, high strength and stable spatial structure

Active Publication Date: 2020-02-21
佛山市博新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore all there is serious shortcoming in these two kinds of methods in above-mentioned prior art

Method used

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  • Adsorption resin and its modification method after secondary crosslinking, hemoperfusion device
  • Adsorption resin and its modification method after secondary crosslinking, hemoperfusion device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1.1 Epoxy activation of adsorption resin:

[0035] Take polystyrene divinylbenzene resin (synthetic crosslinking agent is divinylbenzene with a purity of 80wt%), add 40mL of dichloroethane to soak overnight, add 20mL of dichloroperoxybenzoic acid containing 1.5% dropwise The ethyl chloride solution was stirred and reacted for 24 hours in an ice-water bath (the temperature was controlled at 0-4° C.), and the rotation speed was 200 rpm. After the reaction is completed, it is washed with edible alcohol and deionized water respectively to obtain an epoxidized modified polystyrene divinylbenzene resin.

[0036] 1.2 Hydrolysis of adsorption resin:

[0037] The above-mentioned epoxy-activated adsorption resin was added into 100 mL of 5% sodium hydroxide solution, soaked overnight, and then washed with water until neutral.

[0038] 1.3 Secondary crosslinking of adsorption resin:

[0039] Take 40 g of the above hydrolyzed polystyrene divinylbenzene resin in a 500 mL Erlenmeye...

Embodiment 2

[0041] 2.1 Epoxy activation of adsorption resin:

[0042] Take polystyrene divinylbenzene resin (the synthetic cross-linking agent is divinylbenzene with a purity of 80wt%) and add 40mL of dichloroethane to soak overnight, then add 5mL of 30% hydrogen peroxide and 5g of 1-( 3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) was stirred and reacted at 60° C. for 4 hours, and the rotation speed was 200 rpm. After the reaction is completed, it is washed with edible alcohol and deionized water respectively to obtain an epoxidized modified polystyrene divinylbenzene resin.

[0043] 2.2 Hydrolysis of adsorption resin:

[0044] The above-mentioned epoxy-activated adsorption resin was added into 100 mL of 5% sodium hydroxide solution, soaked overnight, and then washed with water until neutral.

[0045] 2.3 Secondary crosslinking of adsorption resin:

[0046]Take 40 g of the above hydrolyzed polystyrene divinylbenzene resin in a 500 mL Erlenmeyer flask with a stopper, ad...

Embodiment 3

[0047] Example 3: Immobilized ligand after secondary crosslinking of adsorption resin

[0048] 3.1 Immobilized polymyxin B

[0049] Take the secondary cross-linked adsorption resin prepared in Example 1, add 200 mL of an aqueous solution of 2 g of polylysine, and react at 50° C. for 24 h. After the reaction is completed, wash with edible alcohol and deionized water.

[0050] 3.2 Immobilized polyethyleneimine

[0051] Take the secondary cross-linked adsorption resin prepared in Example 1, add 200 mL of an aqueous solution of 3 g of polylysine, and react at 60° C. for 24 h. After the reaction is completed, wash with edible alcohol and deionized water.

[0052] 3.3 Immobilized polylysine

[0053] Take the secondary cross-linked adsorption resin prepared in Example 1, add 200 mL of an aqueous solution of 4 g of polylysine, and react at 55° C. for 24 h. After the reaction is completed, wash with edible alcohol and deionized water.

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Abstract

The invention discloses a secondary crosslinking post-modification method of a polymeric adsorbent. The secondary crosslinking post-modification method comprises the following steps: epoxying and activating a residual double bond on a poly styrene-co-divinyl benzene resin, forming a polyhydroxy surface through hydrolysis, and enabling a hydroxide radical and an epoxy group to perform secondary crosslinking. The hydrophobic polymeric adsorbent forms the polyhydroxy surface through activation and hydrolysis, the hydrophily is improved, the modified functional group is also provided, and the polymeric adsorbent does not need to be modified on a benzene ring. The epoxy chloropropane is used for secondary crosslinking to obtain a poly styrene-co-divinyl benzene resin microsphere with higher strength and more stable space structure. The chloromethyl ether with strong cancerogen or the expensive vinylbenzyl chloride is not used, and the cost is relatively low. The invention further discloses the polymeric adsorbent prepared through the secondary crosslinking post-modification method and a blood perfusion device using the polymeric adsorbent.

Description

technical field [0001] The invention relates to the field of biomedical adsorption materials, in particular to a method for modifying an adsorption resin after secondary post-crosslinking. Background technique [0002] Hemoperfusion mainly uses adsorbents to remove toxins and pathogenic substances in the blood, so as to achieve the purpose of purifying the blood, relieving and treating diseases. Hemoperfusion has obvious clinical curative effect and is an indispensable treatment method at present. [0003] The hemoperfusion device is a commonly used consumable in hemoperfusion, and its filled adsorbent is mainly polystyrene divinylbenzene adsorbent resin, but generally domestically produced polystyrene divinylbenzene adsorbent resin is prepared with 56% purity Divinylbenzene is used as a crosslinking agent, so that the strength of the resin produced is not enough, so it is necessary to modify polystyrene divinylbenzene for further crosslinking. [0004] Post-crosslinking i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/36
CPCA61M1/36B01J20/267B01J20/28083B01J20/28085
Inventor 姜建明李设桥
Owner 佛山市博新生物科技有限公司
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