8 results about "Cancer Causing Agents" patented technology

Provided herein included methods and systems to identify exposure to environmental carcinogens, compounds, and other toxins are disclosed. Additionally provided, include methods and systems to identify risk associated with such environmental carcinogens, compounds, and other toxins. Various embodiments include machine learning models to identify cellular morphometric biomarkers (CMBs). Various methods and systems described herein are capable of using CMBs for diagnostic, prognostic, or forensic purposes. Some embodiments are directed to training a machine learning model for such using CMBs for diagnostic, prognostic, or forensic purposes, including (but not limited to) generating images of biological responses that can be used as a training data set. Additional embodiments are directed to computing devices and / or software that are capable of performing methods as described herein.

The invention relates to the technical field of cosmetics, in particular to vegetable dye pigment and hair dye based on an alcohol-water system and an application method of the vegetable dye pigment and hair dye. The pigment comprises a vegetable dye extract; the raw materials of the plant dye extract comprise at least one of madder, pomegranate rind and rheum officinale. Compared with a traditional chemical synthetic hair dye, the hair dye completely adopts natural plant pigments, food-grade mordants, natural substances such as tannic acid, pH regulators and the like, does not contain aniline cancerogens, greatly reduces the allergy risk and irritation to scalp, and is safe to human bodies.

The invention discloses beta-glucuronidase, a nucleotide sequence of a gene of the beta-glucuronidase and application of the beta-glucuronidase, the gene of the beta-glucuronidase and a protein sequence of the beta-glucuronidase are related to food-borne hazardous substances, and the beta-glucuronidase capable of efficiently and specifically activating cancerogens such as heterocyclic amine HAAs is constructed. The inhibitor designed aiming at the enzyme can reduce interference on intestinal effective microbial communities and human body GUS activity to the maximum extent, side effects are smaller, a research and development basis is provided for further high-throughput drug screening, computer-aided drug design and antibody drug development, and the inhibitor has a great application prospect.

Provided herein included methods and systems to identify exposure to environmental carcinogens, compounds, and other toxins are disclosed. Additionally provided, include methods and systems to identify risk associated with such environmental carcinogens, compounds, and other toxins. Various embodiments include machine learning models to identify cellular morphometric biomarkers (CMBs). Various methods and systems described herein are capable of using CMBs for diagnostic, prognostic, or forensic purposes. Some embodiments are directed to training a machine learning model for such using CMBs for diagnostic, prognostic, or forensic purposes, including (but not limited to) generating images of biological responses that can be used as a training data set. Additional embodiments are directed to computing devices and / or software that are capable of performing methods as described herein.

Provided herein included methods and systems to identify exposure to environmental carcinogens, compounds, and other toxins are disclosed. Additionally provided, include methods and systems to identify risk associated with such environmental carcinogens, compounds, and other toxins. Various embodiments include machine learning models to identify cellular morphometric biomarkers (CMBs). Various methods and systems described herein are capable of using CMBs for diagnostic, prognostic, or forensic purposes. Some embodiments are directed to training a machine learning model for such using CMBs for diagnostic, prognostic, or forensic purposes, including (but not limited to) generating images of biological responses that can be used as a training data set. Additional embodiments are directed to computing devices and / or software that are capable of performing methods as described herein.

The present disclosure demonstrates that cancer cells secrete succinate into the extracellular environment, which in turn increases the migration ability of macrophages and mediates cancer-associated macrophage polarization. In mouse models, succinate not only induces cancer cell epithelial-mesenchymal transition, enhances cancer cell migration ability, but also promotes cancer metastasis. The present disclosure also indicates that the concentration of succinate in the serum of lung cancer patients is higher than that of healthy subjects, which means that cancer cells release a large amount of succinate into the circulatory system during the development and progression of cancer. As shown in the present disclosure, serum succinate has high discriminative power and can be used as a new class of circulating metabolic carcinogen for predicting non-small cell lung cancer. In addition, in LLC tumor models, the increase in succinate concentration is accompanied by an increase in TAMs in subcutaneous tumors and more severe cancer metastasis, so the serum succinate may be an effective therapeutic biomarker for treating NSCLC. Therefore, the present disclosure also provides an anti-succinate antibody that can be used as a cancer therapeutic agent.

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses a betahistine mesylate tablet composition and a preparation method thereof. The composition comprises a drug-containing resin compound formed by betahistine mesylate and high-molecular polymer resin and pharmaceutical auxiliary materials, and the mass ratio of the drug to the resin is 1: 6-1: 1, preferably 1: 3-1: 2; the resin is sodium polystyrenesulfonate. The preparation method comprises the following steps: blending the medicine and the resin in water, drying to obtain a compound, and mixing and tabletting with the disintegrating agent, the filling agent and the like. The core of the invention lies in that the generation of a cancerogen N-nitrosobetahistine is effectively inhibited from the source by physically isolating the medicine through the resin compound, and the problem of stability caused by the use of oily auxiliary materials in the prior art is solved. The obtained tablet is rapid and complete in dissolution, uniform in content, few in related substances, capable of remarkably slowing down nitrosamine growth under the accelerated stability condition, simple and convenient in process and suitable for industrial production, and is used for treating dizziness or equilibrium disorder.

The invention relates to the technical field of animal models, and particularly discloses a multi-stage bladder cancer model and a construction method and application thereof. According to the application, specific components of common cigarette extracts popular in the market are identified, urine components of clinical smokers are collected and detected, the fact that benzene and NKK exist in the cigarettes and the urine of the smokers at the same time is successfully found, and the cigarette components benzene and NKK are selected for bladder cancer modeling; benzene and NNK are strong cancerogens existing in tobacco components and urine of smokers, the content of the components is high, the physiological and pathological process of bladder cancerization caused by long-term stimulation after the smokers inhale smoke, enter blood through lungs and form urine through kidneys can be directly simulated, and real life conditions are better met. The multi-stage bladder cancer model is closer to biological characteristics of bladder cancer, has specific exposure factors, and is short in preparation period, high in tumor formation rate, high in operability and good in repeatability.