The invention provides a chlorine dioxide-containing disinfectant hand sanitizer, which consists of a surfactant, a chelating agent, a moisturizing agent, a thickener, a water-soluble emollient, a bactericide precursor, a pH regulator, an essence and deionized water Made according to a certain weight ratio. The disinfectant hand sanitizer provided by the invention is mild in nature, safe and environmentally friendly, and realizes cleaning, skin care, and sterilization simultaneously. Chlorine dioxide is selected as the bactericide component, and the bactericidal effect is good, the action time is short, and the sterilizing rate is high, and bacteria will not Tolerance to it is produced, and it takes effect immediately after use. In addition, the hand sanitizer of the present invention will not produce carcinogens such as chloroform during use, and the biodegradation rate of all surfactants is also more than 90%, which meets national requirements and is environmentally friendly. Toxic, harmless, safe and environmentally friendly, people can safely use this product for a long time.