The invention belongs to the technical field of health food and biological medicine, and particularly relates to a composition for detoxifying stomach and intestine and losing weight and application of the composition. The composition provided by the invention comprises three or any two of the following three components: cellulose, grease and adsorbents, wherein the components in the composition are mixed, excipients and additives are added to prepare capsules, pills, tablets, granules, suspensions, jellies, beverages and the like, and the composition can be used as common food, health-care food and / or medicine, and can promote human bodies to discharge various harmful toxicants, such as harmful microorganisms, heavy metals, harmful gases, harmful organic matters and inorganic matters, cancerogens and the like in gastrointestinal tracts; The composition is beneficial for improving sleep, low emotion, acne, chloasma, cyasma, skin itch, constipation, less defecation, diarrhea, wet, stink and itching anus, intestinal flatulence and too much fart, stinky fart and excrement, and reducing blood ammonia, and can be used for obese people and has a weight-losing effect.