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Cyclodextrin additive as well as preparation method and application thereof

A technology of cyclodextrin and additive, applied in the field of cyclodextrin additive and its preparation

Pending Publication Date: 2021-04-20
宁波合康生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3,4-Benzopyrene is a highly active compound that exists in mainstream smoke and side stream smoke: BaP is considered to be a highly active carcinogen, but it is not a direct carcinogen, and must pass through the cells in μL granules. Inactivation of mixed-function oxidases is carcinogenic
[0014] In summary, there is currently no additive on the market that can remove most of the harmful components in tobacco products or / and betel nut products, and maintain the flavor and aroma of tobacco products or / and betel nut products

Method used

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  • Cyclodextrin additive as well as preparation method and application thereof
  • Cyclodextrin additive as well as preparation method and application thereof
  • Cyclodextrin additive as well as preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0103] Method 1: The cyclodextrin additive product is liquid, and the preparation method includes the following steps:

[0104] Weigh a certain amount of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin and other envelope carriers, dissolve in distilled water and other solvents to obtain a cyclodextrin solution; weigh a certain amount of glutathione , cysteine, selenocysteine, zinc gluconate, SOD and other antioxidants are dissolved in distilled water to obtain a synergistic antioxidant aqueous solution; weigh a certain amount of nicotine, organic acids, spices and other active substances and dissolve them in a suitable solvent A solution was obtained in ; mix the above solution, pass N 2 Protect, seal and avoid light, stir at 50-70°C for 5 hours, and cool the viscous solution to room temperature to obtain a liquid additive with carcinogen adsorption function, synergistic anti-oxidation function and flavor release function.

[0105] Method 2: The cyclodextrin additive produc...

Embodiment 1

[0119] Use a 3x10ml Erlenmeyer flask and a balance to weigh at room temperature: (1) Weigh 2.0 g of α-cyclodextrin and 2.0 g of γ-cyclodextrin, dissolve them in a mixed solvent of 1.5 g of distilled water and 2.5 g of glycerin, and heat Stir to obtain cyclodextrin aqueous solution; (2) weigh glutathione 0.01g, L-cysteine ​​0.01g, selenocysteine ​​0.001g, zinc gluconate 0.1g, SOD (superoxide dismutase) 0.01g (200I.U.) was dissolved in 0.5g distilled water to obtain a synergistic antioxidant solution; (2) weigh 0.0mg nicotine, 100.0mg citric acid, and 0.05g menthol were dissolved in 0.5g glycerin to obtain an active substance solution; mix the above Two solutions, through N 2 Protect, seal and avoid light, stir at 40-50°C for 2.5 hours, and cool to room temperature to obtain a liquid additive that simultaneously includes carcinogen adsorption function, synergistic anti-oxidation function, flavor and other active substance release functions.

Embodiment 2

[0121] Weigh respectively with a 3x10ml Erlenmeyer flask and a balance at room temperature: (1) 2.0g of α-cyclodextrin and 2.0g of γ-cyclodextrin, dissolve in 1.5g of distilled water and 2.5g of glycerol mixed solvent, heat and stir to obtain cyclodextrin Dextrin aqueous solution; (2) take glutathione 0.01g, L-cysteine ​​0.01g, selenocysteine ​​0.001g, zinc gluconate 0.01g, SOD (superoxide dismutase) 0.01g ( 200I.U.) was dissolved in 0.5g distilled water to obtain a synergistic antioxidant solution; (3) nicotine 200.0mg, citric acid 0.0mg, menthol 0.05g were dissolved in 0.5g glycerin to obtain an active substance solution; the above three solutions were mixed , through N 2 Protect, seal and avoid light, stir at 40-50°C for 2.5 hours, and cool to room temperature to obtain a liquid additive including carcinogen adsorption function, synergistic anti-oxidation function, flavor and other active substance release functions, and nicotine content in cyclodextrin additives The conce...

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Abstract

The invention relates to a cyclodextrin additive with a cancerogen filtering function, an antioxidant function and a slow release function. The cyclodextrin additive comprises the following raw materials in parts by weight: a cyclodextrin compound, an antioxidant component, a bioactive component and a solvent, wherein cyclodextrin has the function of adsorbing and filtering carcinogenic harmful substances after dissolving in the solvent; after the antioxidant component is enveloped or adsorbed by the cyclodextrin compound, the synergistic antioxidant function is kept; and bioactive substances enveloped by the cyclodextrin compound achieve the purpose of slow release. Compared with the prior art, the cyclodextrin additive has the advantages that harmful cancerogen (80-90%) in mainstream smoke and harmful ingredients in a food storage and smoking process can be remarkably reduced, and damage to the oral cavity, respiratory tract and lung of a consumer in the eating process is prevented and relieved. Besides, special original active substances can be prevented from being influenced by a filtering system or / and the newly added active substances are slowly released, and besides, the requirements of consumers for reducing health hazards and improving the product quality and functions are met.

Description

technical field [0001] The invention relates to the technical field of tobacco and food additives, in particular to a cyclodextrin additive with the functions of filtering out carcinogens, anti-oxidation and sustained release, its preparation method and application. Background technique [0002] Smoking is harmful to health. There are 1.1 billion smokers in the world, and the number of deaths caused by smoking is as high as 6 million every year, which exceeds the sum of deaths caused by AIDS, tuberculosis and malaria. Related diseases caused by smoking include lung cancer, oral cancer, laryngeal cancer, esophageal cancer, heart disease, tracheitis, emphysema, etc., which are difficult to cure. Among them, nearly 70-80% of lung cancer deaths are caused by smoking. According to the survey, there are nearly 350 million smokers in my country, and about 740 million non-smokers are exposed to the harm of second-hand smoke; the annual death toll due to smoking-related diseases exce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/125A24D3/06
Inventor 施雄伟
Owner 宁波合康生物医药科技有限公司
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