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A kind of preparation method of iodine dressing

An iodine element and microcapsule technology, which is applied in pharmaceutical formulations, bandages, microcapsules, etc., can solve problems such as improving the irritation of iodine-containing dressings, increasing solvent consumption, and unfavorable compliance, and achieving improved hydrophilicity and competitive advantages. , the effect of improving safety

Active Publication Date: 2020-09-18
江西3L医用制品集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to obtain a safer iodine-containing dressing, the method of directly adding iodine element to the adhesive will cause the iodine element to directly contact the skin, which will increase the irritation of the iodine-containing dressing, which is not conducive to improving the compliance of use
However, the method of using other solvents to pre-dissolve, such as benzene, carbon tetrachloride, and alcohol with good solubility of iodine elemental substance, the toxicity of benzene and carbon tetrachloride is large, and the alcohol system volatilizes during the preparation of iodine adhesive, and still exists. The problem of direct contact of iodine element with the skin, and increased solvent consumption
Moreover, iodine-containing dressings are prepared in the form of iodine element or solution, and its iodine will cause greater loss due to volatilization.

Method used

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  • A kind of preparation method of iodine dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of iodine-containing dressing, said preparation method comprising the following steps:

[0028] (1) Preparation of iodine microcapsules:

[0029] Pre-grind the iodine element into powder particles with a particle size of 1 μm, and then add the above raw materials according to the mass ratio of polyethylene glycol 1000: polyethylene glycol 800: glycerol: iodine particles at a ratio of 55:40:8:5, and heat at 35°C Stir and disperse evenly under the environment of 20°C to obtain iodine microcapsules;

[0030] (2) Preparation of iodine adhesive:

[0031] The mass ratio of the iodine adhesive is 20 parts of isooctyl acrylate; 2 parts of hydroxyethyl acrylate; 5 parts of vinyl acetate; 8 parts of acrylic acid; 34 parts of ethyl acetate; 32 parts of ethanol; 1 part of iodine microcapsules;

[0032] After stirring evenly, import it into the reaction kettle and pass it into the nitrogen protection. The flow rate of the nitrogen gas should be controlled at 1...

Embodiment 2

[0039] A preparation method of iodine-containing dressing, said preparation method comprising the following steps:

[0040] (1) Preparation of iodine microcapsules:

[0041] Pre-grind the elemental iodine into powder particles with a particle size of 3 μm, and then add the above raw materials according to the mass ratio of polyethylene glycol 1000: polyethylene glycol 800: glycerol: iodine particles at a ratio of 60:35:9:8, and heat at 35 °C Stir and disperse evenly under the environment of 20°C to obtain iodine microcapsules;

[0042] (2) Preparation of iodine adhesive:

[0043] The mass ratio of the iodine adhesive is 25 parts of isooctyl acrylate; 1 part of hydroxyethyl acrylate; 3 parts of vinyl acetate; 5 parts of acrylic acid; 40 parts of ethyl acetate; 25 parts of ethanol; 1.5 parts of iodine microcapsules;

[0044] After stirring evenly, import it into the reaction kettle and pass it into the nitrogen protection. The flow rate of the nitrogen gas should be controlled...

Embodiment 3

[0051] A preparation method of iodine-containing dressing, said preparation method comprising the following steps:

[0052] (1) Preparation of iodine microcapsules:

[0053] Pre-grind the iodine element into powder particles with a particle size of 5 μm, and then add the above raw materials according to the mass ratio of polyethylene glycol 1000: polyethylene glycol 800: glycerol: iodine particles in a ratio of 70:30:10:10. Stir and disperse evenly under the environment of 20°C to obtain iodine microcapsules;

[0054] (2) Preparation of iodine adhesive:

[0055] The mass ratio of the iodine adhesive is 30 parts of isooctyl acrylate; 0.5 parts of hydroxyethyl acrylate; 2 parts of vinyl acetate; 1 part of acrylic acid; 48 parts of ethyl acetate; 18 parts of ethanol; 2 parts of iodine microcapsules;

[0056] After stirring evenly, import into the reactor, and pass into nitrogen protection, the flow rate of nitrogen should be controlled at 165L / h; turn on the stirrer in the reac...

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Abstract

The invention discloses a preparation method of an iodine-containing dressing. According to the invention, glycerin and polyethylene glycol are used for coating iodine to form microcapsules; on the premise that an antibacterial effect is guaranteed, a slow release effect is improved, the irritation of the dressing to the skin is reduced, the hygroscopicity of the dressing can be improved, and theuse comfort of the dressing is improved. According to the preparation method, three types of carcinogens-polyvinylpyrrolidone can be avoided, so the obtained dressing is higher in safety.

Description

technical field [0001] The invention relates to a medical dressing, in particular to an iodine-containing dressing and a preparation method thereof. Background technique [0002] Clinically, the surgical or wound surface is an ideal environment for bacteria to grow and reproduce. Ordinary dressings can only protect the wound to a certain extent, so as to avoid being touched by objects and prevent external dust from polluting the wound. In the prior art, if the patent No. is 2008101071653, the patent name is "Its Preparation Method for Disposable Surgical Drapes Pasted with Povidone-iodine Glue", which provides a technical method for preparing surgical towels pasted with iodophors. In addition to the above functions, it can also have antibacterial and antibacterial effects on the skin around the wound, keep the wound in a sterile environment, prevent the wound from being infected by bacteria, and promote wound healing. [0003] But iodophor is an amorphous combination of ele...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/58A61L15/44A61L15/46A61L15/42A61L15/18A61L15/24
CPCA61L15/18A61L15/24A61L15/42A61L15/44A61L15/46A61L15/58A61L2300/106A61L2300/404A61L2300/622C08L33/02C08L33/08C08L33/04
Inventor 童晓凤熊小强赵岚
Owner 江西3L医用制品集团股份有限公司
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