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Layer-by-layer click bonding self-assembly-based polylactic acid material and preparation method thereof

A polylactic acid material and self-assembly technology, which is used in the fields of biomedical materials, polymer chemistry and biomacromolecule self-assembly to achieve the effect of maintaining natural conformation and biological activity, wide sources and strong stability

Active Publication Date: 2017-09-15
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Layer-by-layer click bonding self-assembly-based polylactic acid material and preparation method thereof
  • Layer-by-layer click bonding self-assembly-based polylactic acid material and preparation method thereof
  • Layer-by-layer click bonding self-assembly-based polylactic acid material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0031]Example 1: The polylactic acid material based on layer-by-layer click bonding self-assembly is composed of a substrate and a modification layer. It is obtained by surface modification through click-bonding self-assembly; wherein, the modification layer contains alkynyl-containing cellulose sulfate and azido-chitosan which are layer-by-layer click-bonding self-assembled on the surface of the substrate.

[0032] Such as figure 1 , 2 , Shown in 3, the preparation method of above-mentioned material is as follows:

[0033] (1) Azidation treatment on the surface of polylactic acid material

[0034] Preparation of polylactic acid diaphragm: Stir and mix the two raw materials according to the ratio of polylactic acid: dichloromethane = 5g: 50mL. After the polylactic acid is completely dissolved, pour the solution into a flat-bottomed glass cuvette, and dry it at room temperature for 24 hours. A polylactic acid film was obtained. Then, the film was stirred and cleaned with 50...

Embodiment 2

[0048] Embodiment 2: This polylactic acid material based on layer-by-layer click bonding self-assembly is composed of a substrate and a modification layer. The substrate is a surface azide polylactic acid material. It is obtained by surface modification through click-bonding self-assembly; wherein, the modification layer contains alkynyl-containing cellulose sulfate and azido-chitosan which are layer-by-layer click-bonding self-assembled on the surface of the substrate.

[0049] The preparation method of above-mentioned material is as follows:

[0050] (1) Azidation treatment on the surface of polylactic acid material:

[0051] Preparation of polylactic acid membrane: Stir and mix the two raw materials according to the ratio of polylactic acid: dichloromethane = 7.5g: 75mL. After the polylactic acid is completely dissolved, pour the solution into a flat-bottomed glass cuvette and dry it at room temperature for 36 hours. , to obtain a polylactic acid film; then stir and wash t...

Embodiment 3

[0063] Embodiment 3: The polylactic acid material based on layer-by-layer click bonding self-assembly is composed of a substrate and a modification layer. It is obtained by surface modification through click-bonding self-assembly; wherein, the modification layer contains alkynyl-containing cellulose sulfate and azido-chitosan which are layer-by-layer click-bonding self-assembled on the surface of the substrate.

[0064] The preparation method of above-mentioned material is as follows:

[0065] (1) Azidation treatment on the surface of polylactic acid material:

[0066] Preparation of polylactic acid membrane: Stir and mix the two raw materials according to the ratio of polylactic acid: dichloromethane = 10g: 100mL. After the polylactic acid is completely dissolved, pour the solution into a flat-bottomed glass cuvette and dry it at room temperature for 48 hours. A polylactic acid film was obtained. Subsequently, the film was stirred and cleaned with 50% ethanol aqueous soluti...

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Abstract

The invention discloses a layer-by-layer click bonding self-assembly-based polylactic acid material and a preparation method thereof. The polylactic acid material is prepared from a base material and a modified layer. The preparation method comprises the steps of (1) azidation treatment of the surface of the polylactic acid material; (2) preparation of azide chitosan and alkynyl-containing cellulose sulfate; (3) preparation of an azide chitosan solution and an alkynyl-containing cellulose sulfate solution; and (4) layer-by-layer click bonding self-assembly of the azide chitosan and the alkynyl-containing cellulose sulfate on the surface of the polylactic acid material, namely alternately soaking the treated polylactic acid material into the azide chitosan solution and the alkynyl-containing cellulose sulfate solution for a period of time separately, taking out the polylactic acid material, cleaning by using ultra-pure water, drying and repeating the processes, so that layer-by-layer click self-assembly modification of the chitosan and the cellulose sulfate on the surface of the polylactic acid material is achieved. The material prepared by using the method has excellent protein adsorption resistance, and the surface hydrophilicity is significantly improved, thereby improving the blood compatibility of the surface of the material.

Description

technical field [0001] The invention belongs to the technical fields of biomedical materials, polymer chemistry and biomacromolecule self-assembly, and specifically relates to a polylactic acid material with improved surface blood compatibility based on layer-by-layer click-bonding self-assembly and a preparation method thereof. Background technique [0002] Polylactic acid is a biomaterial with good biocompatibility, biosafety and degradability. It has been widely used in the field of biomedical materials such as bone fixation repair materials, assembly engineering scaffold materials, and drug controlled release carriers. However, polylactic acid materials are highly hydrophobic, and when in direct contact with blood, it is easy to cause a series of non-specific protein adsorption in plasma, platelet adhesion, and finally lead to coagulation, thereby forming adverse reactions of thrombus. Therefore, improving the blood of polylactic acid materials Compatibility is imminent....

Claims

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Application Information

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IPC IPC(8): C08G63/91
CPCC08G63/912
Inventor 彭林才李辉
Owner KUNMING UNIV OF SCI & TECH
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