Method for preparing polyurethane-nanometer silver long-acting antibacterial film by modification after heat treatment

Abstract

The invention relates to a method for preparing a polyurethane-nanosilver long-acting antibacterial film by a post-heat treatment modification method, which includes the following steps: (1) diisocyanate and polytetrahydrofuran are mixed to react; a cross-linking agent and an acetone solution of a chain extender are added, dimethylolpropionic acid and a catalyst are added, reaction takes place, and thereby PU (polyurethane) is obtained; a dimethylformamide solution of silver nitrate is added into a polyurethane solution, a film is formed after uniform stirring, heat treatment is carried out, and thereby a polyurethane-nanosilver film is obtained; (2) 4,4'-dihydroxybenzophenone reacts with long-chain alkyl halide, so that 4,4'-bis-long-chain alkoxy benzophenone is obtained; the 4,4'-bis-long-chain alkoxy benzophenone reacts with hydrazine hydrate, so that 4,4'-bis-long-chain alkoxy benzophenone hydrazone is obtained; and the 4,4'-bis-long-chain alkoxy benzophenone hydrazone undergoes oxidation reaction, so that long-chain alkyl diazomethane is obtained; (3) the long-chain alkyl diazomethane is dissolved into a solvent, and is uniformly applied onto the surface of the polyurethane-nanosilver film, and after heat treatment, the polyurethane-nanosilver long-acting antibacterial film is obtained. The method can be used for realizing long-acting bacteria resistance.

Description

technical field [0001] The invention relates to a method for preparing a polyurethane-nanometer silver long-acting antibacterial film by a modification method after heat treatment, and belongs to the technical field of antibacterial materials. Background technique [0002] Polyurethane is an important class of medical polymer materials with excellent blood compatibility, good biological stability and mechanical properties. Fu Qiang et al. (Tan Hong, Li Jiehua, Fu Qiang. Design, preparation and performance of biomedical phospholipidated polyurethane. Chinese Science: Chemistry, 42(5), pp 661-675, 2012.) showed that polyurethane has the same properties as natural blood vessels The best matching compliance, especially for blood contact devices, has an irreplaceable role in surgical treatment. However, interventional medical polymer materials need to have long-term antibacterial properties, otherwise it is easy to cause postoperative infection in clinical application, leading t...

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Problems solved by technology

However, this hydrophobic modification method requires special functional groups on the surface of the polymer, and in order to ensure the smooth implementation of subsequent modification reactions, the functional groups (such as alkynyl, alkenyl, azide, etc.) The chemical properties are often relatively active and prone to side reactions and deterioration, which makes the synthesis of this type of polymer difficult, and is not suitable for surface modification of ordinary polyurethane materials.

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