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Solution preparation for aerosol inhalation for treating child cough and preparation method thereof

A technology for atomized inhalation and infantile cough and asthma, applied in the field of pharmacy, can solve the problems of poor compliance, low bioavailability, and slow onset of oral liquid, etc. The effect of the drug route

Inactive Publication Date: 2017-09-22
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to the young age of children, the compliance of oral liquid is poor, and the onset of oral liquid is slow, and the bioavailability is low. Therefore, it is urgent to develop a safer dosage form, so that the medicine can directly enter the respiratory tract, and the dose is small. Quick effect, high bioavailability, and less adverse reactions, improving the safety of clinical medication

Method used

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  • Solution preparation for aerosol inhalation for treating child cough and preparation method thereof
  • Solution preparation for aerosol inhalation for treating child cough and preparation method thereof
  • Solution preparation for aerosol inhalation for treating child cough and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Preparation of active ingredients:

[0031] 50 parts of ephedra, 100 parts of bitter almond, 400 parts of gypsum, 50 parts of licorice, 167 parts of honeysuckle, 167 parts of forsythia, 167 parts of Anemarrhena, 167 parts of scutellaria, 167 parts of Radix Radix, 167 parts of Ophiopogon japonicus, 167 parts of Houttuynia cordata

[0032] Weigh the eleven herbs according to the above weight parts, add water to the gypsum and decoct for 0.5 hours, add the remaining ten herbs such as ephedra, add water and decoct twice, each time for 1 hour, combine the decoctions, filter, and concentrate the filtrate to a relative density of 80°C 1.10-1.15, let it cool, add ethanol to make the alcohol content reach 75%, stir well, let it stand for 24 hours, filter, recover ethanol from the filtrate and concentrate to 80°C to a clear paste with a relative density of 1.20-1.25, add appropriate amount of water, Stir evenly, refrigerate at 4-7°C for 36-38 hours, perform ultrafiltration, a...

Embodiment 2

[0037] (1) Preparation of active ingredient: same as Example 1.

[0038] (2) Preparation of solution for atomized inhalation:

[0039]

[0040] Weigh the active ingredient according to the prescription amount, add an appropriate amount of water for injection, and stir evenly to obtain solution 1; take sodium chloride, add appropriate amount of water for injection, stir to dissolve, and obtain solution 2; combine solution 1 and solution 2, and stir evenly to obtain solution 2. Solution 3: Take another appropriate amount of disodium hydrogen phosphate, add an appropriate amount of water for injection to prepare a 0.4mol / L solution, stir slowly and add it to solution 3, adjust the pH value to 4.0-6.0, add an appropriate amount of water for injection, fill and seal, Instantly.

Embodiment 3

[0042] (1) Preparation of active ingredient: same as Example 1.

[0043] (2) Preparation of solution for atomized inhalation:

[0044]

[0045] Weigh the active ingredient according to the prescription amount, add an appropriate amount of water for injection, and stir evenly to obtain solution 1; take magnesium chloride and citric acid, add appropriate amount of water for injection, stir to dissolve, and obtain solution 2; combine solution 1 and solution 2, stir evenly, Obtain solution 3; take another appropriate amount of disodium hydrogen phosphate, add appropriate amount of water for injection to prepare a 0.2mol / L solution, stir slowly and add it to solution 3, adjust the pH value to 5.0-6.0, add appropriate amount of water for injection, fill and seal , that is.

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PUM

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Abstract

The invention relates to a solution preparation for aerosol inhalation for treating child cough, and belongs to the field of pharmaceutics. The solution preparation for aerosol inhalation for treating child cough comprises effective constituents, an isotonic agent and a solvent, also may including a buffer. According to the solution preparation, the gap of the current domestic market is filled; moreover, the solution preparation is specially designed for patients need aerosol inhalation and is matched with a nebulizer in use, and use process is convenient; compared with a child lung-heat cough oral liquid, the administration route is different, the using dosage is reduced, and the safety is improved.

Description

technical field [0001] The invention relates to a solution preparation for atomized inhalation for treating infantile cough and asthma and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Children's Feire Kechuan Oral Liquid is composed of Maxing Shigan Decoction, Baihu Decoction, and Yinqiao San. Houttuynia cordata and Ophiopogon japonicus have eleven ingredients. Maxing Shigan decoction plus Baihu decoction can clear away heat and detoxify, clear the lungs and resolve phlegm. It is used for fever, sweating, slight aversion to wind and cold, cough, Phlegm yellow, or combined with wheezing, dry mouth and thirst, Houttuynia cordata and Scutellaria baicalensis are added to strengthen the effect of clearing lung heat. Cough is the target, and it is the first-selected Chinese patent medicine for the treatment of children's colds. [0003] However, due to the young age of children, the compliance of oral liquid is poor, and the ons...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/72A61P11/06A61P11/14A61K33/06
CPCA61K9/0078A61K9/08A61K33/06A61K36/17A61K36/195A61K36/315A61K36/355A61K36/484A61K36/539A61K36/634A61K36/736A61K36/78A61K36/8964A61K36/8968A61K47/02A61K47/12A61K2300/00
Inventor 张保献
Owner BEIJING INCREASEPHARM CORP LTD
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