Solution preparation for aerosol inhalation for treating child cough and preparation method thereof
A technology for atomized inhalation and infantile cough and asthma, applied in the field of pharmacy, can solve the problems of poor compliance, low bioavailability, and slow onset of oral liquid, etc. The effect of the drug route
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[0029] Example 1
[0030] (1) Preparation of active ingredients:
[0031] 50 parts of ephedra, 100 parts of bitter almond, 400 parts of gypsum, 50 parts of licorice, 167 parts of honeysuckle, 167 parts of forsythia, 167 parts of Anemarrhena, 167 parts of Radix Scutellariae, 167 parts of Radix isatidis, 167 parts of Ophiopogon japonicus, 167 parts of Houttuynia cordata
[0032] Weigh the eleven medicines according to the above weight portion, decoct gypsum in water for 0.5 hours, add the remaining ten flavors such as ephedra, add water and decoct twice for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 80°C It is 1.10-1.15, let cool, add ethanol to make the alcohol content reach 75%, stir well, let stand for 24 hours, filter, the filtrate recovers the ethanol and concentrates to 80°C with a relative density of 1.20-1.25. Add appropriate amount of water. Stir well, refrigerate at 4-7°C for 36-38 hours, ultrafiltration, and concen...
Example Embodiment
[0036] Example 2
[0037] (1) Preparation of active ingredients: the same as in Example 1.
[0038] (2) Preparation of aerosol inhalation solution:
[0039]
[0040] Weigh the active ingredients according to the prescription, add an appropriate amount of water for injection, and stir to obtain solution 1; take sodium chloride, add an appropriate amount of water for injection, and stir to dissolve to obtain solution 2; combine solution 1 and solution 2 and stir evenly to obtain Solution 3; take another appropriate amount of disodium hydrogen phosphate, add appropriate amount of water for injection to prepare a 0.4mol / L solution, stir and slowly add to solution 3, adjust the pH to 4.0-6.0, add appropriate amount of water for injection, fill and seal, Immediately.
Example Embodiment
[0041] Example 3
[0042] (1) Preparation of active ingredients: the same as in Example 1.
[0043] (2) Preparation of aerosol inhalation solution:
[0044]
[0045] Weigh the active ingredients according to the prescription, add an appropriate amount of water for injection, and stir to obtain solution 1; take magnesium chloride and citric acid, add an appropriate amount of water for injection, and stir to dissolve to obtain solution 2; combine solution 1 and solution 2, and stir evenly. Obtain solution 3; take another appropriate amount of disodium hydrogen phosphate, add appropriate amount of water for injection to prepare a 0.2mol / L solution, stir and slowly add to solution 3, adjust the pH to 5.0-6.0, add appropriate amount of water for injection, fill and seal , That is.
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