Preparation method of solid-phase micro-extraction fiber with specificity to sulfanilamide medicine

A technology for extracting sulfa drugs and fibers, applied in separation methods, chemical instruments and methods, alkali metal compounds, etc., to achieve strong specific adsorption capacity, high recovery rate, and solve the effects of poor selective adsorption

Active Publication Date: 2017-10-10
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is little disclosure about the specific solid-phase microextraction fiber for sulfa drugs.

Method used

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  • Preparation method of solid-phase micro-extraction fiber with specificity to sulfanilamide medicine
  • Preparation method of solid-phase micro-extraction fiber with specificity to sulfanilamide medicine
  • Preparation method of solid-phase micro-extraction fiber with specificity to sulfanilamide medicine

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Embodiment 1

[0054] The preparation method of solid phase microextraction fiber material is as follows:

[0055] The preparation method of the solid-phase microextraction fiber specific to sulfonamides comprises the following steps:

[0056] (1) Dissolve 556mg of sulfamethazine in 5.5mL of acetonitrile, ultrasonically dissolve it fully, then add 256μL of functional monomer methacrylic acid for 5min, and then add the cross-linking agent ethylene glycol dimethacrylic acid Esters 1.128mL and 1.188mL 3-(trimethoxysilyl)propyl acrylate, ultrasonic 5min to fully mix all reagents, then add 25mg of azobisisobutyronitrile, ultrasonically dissolved to obtain a pre-polymerization solution;

[0057] (2) Ultrasonicate the pre-polymerization solution prepared in step 1) for 2 minutes, pass nitrogen gas for 2 minutes, repeat the operation 5 to 10 times to remove oxygen, and store in a refrigerator at 4°C away from light;

[0058] Solid phase microextraction material preparation, its steps are as follows...

Embodiment 2

[0066] Characterization of Adsorption Properties of Solid Phase Microextraction Materials

[0067] (1) Dynamic adsorption experiment

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Abstract

The invention belongs to the field of extraction media, and particularly relates to a preparation method of a solid-phase micro-extraction fiber for extracting and separating a residue of a trace sulfanilamide medicine in a food sample. A preparation method of a solid-phase micro-extraction fiber with specificity to a sulfanilamide medicine comprises the following steps of (1), preparing a prepolymerization solution; (2), carrying out deoxidization operation on the prepolymerization solution prepared and obtained in the step (1); (3), preparing a solid-phase micro-extraction material. The preparation method has the beneficial effects that the solid-phase micro-extraction material prepared by the method provided by the invention has the characteristics of being convenient to operate and use, high in specific adsorption capacity, high in recovery rate and low in preparation cost; meanwhile, the defect that the amount of a solvent needed by a conventional sample pretreatment technique is large is also overcome. Moreover, the material prepared by the preparation method is simple in preparation process steps, and can be cyclically utilized for multiple times; the problem that a commercialized solid-phase micro-extraction fiber is poor in selective adsorption is solved.

Description

technical field [0001] The invention belongs to the field of extraction media, and in particular relates to a preparation method of a solid-phase microextraction fiber used for the extraction and separation of trace amounts of sulfonamide drug residues in food samples. Background technique [0002] Sulfonamide drugs have the advantages of low price, convenient use and remarkable drug effect, so they are widely used in clinical treatment and animal husbandry for the prevention and treatment of infectious diseases. The non-standard application of sulfonamide veterinary drugs is likely to cause its residues in animal tissues, and its potential carcinogenicity and drug resistance are gradually emerging, which will eventually affect human health. At the same time, the residues of sulfonamide veterinary drugs also limit my country's The export of animal food affects the economic development of our country. In order to ensure the quality and safety of food and the health of human b...

Claims

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Application Information

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IPC IPC(8): B01J20/285B01J20/28B01J20/30B01D15/20
CPCB01D15/206B01J20/28023B01J20/285B01J2220/52B01J2220/86
Inventor 何金兴王璇梁金玲
Owner QILU UNIV OF TECH
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