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A pharmaceutical composition of Shuangjinlian, a solution for atomized inhalation of Shuangjinlian, its preparation method and application

A technology of atomization inhalation and composition, applied in the field of medicine, can solve the problems of large dosage and low inhibition rate of viral pneumonia, and achieve the effects of reducing dosage of medicine, improving patient compliance, and avoiding first-pass effect.

Active Publication Date: 2018-05-29
HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent: 011382457, notification number CN1150931C, relates to a Shuangjinlian oral liquid for treating colds and flu and its preparation method. Table, the effect of heat-clearing and detoxification, used for fever, pain, cough and other diseases caused by exogenous wind pathogens and colds, can be used to treat respiratory and lung infections, tonsillitis, pharyngitis, viral pneumonia and influenza, but the patent said The Shuangjinlian oral liquid still has some problems, for example, large dosage, low inhibition rate to viral pneumonia, etc.

Method used

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  • A pharmaceutical composition of Shuangjinlian, a solution for atomized inhalation of Shuangjinlian, its preparation method and application
  • A pharmaceutical composition of Shuangjinlian, a solution for atomized inhalation of Shuangjinlian, its preparation method and application
  • A pharmaceutical composition of Shuangjinlian, a solution for atomized inhalation of Shuangjinlian, its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation method of the pharmaceutical composition of Shuangjinlian and the solution for nebulization inhalation of Shuangjinlian is as follows:

[0049] a. According to the weight ratio, crush 42% of the mountain silver flower, 8% of the nasturtium flower, 14% of the forsythia, and 10% of the Bupleurum bupleurum into the water with a temperature of 60°C. After soaking for 2 hours, the medicinal liquid is dynamically extracted by pump circulation, and the extracted medicinal liquid is then dynamically soaked in water at a temperature of 60°C for 1.5 hours, then decocted and filtered, and concentrated to relative density under vacuum when cooled to 60°C After the temperature is 1.20 (measured at 80°C), slowly add ethanol when the medicinal solution is cooled to 40°C, fully stir when the alcohol content reaches 70%, leave it for 12 hours, take the supernatant, reduce Press and recover the ethanol until there is no alcohol smell, and obtain the alcohol paste (relativ...

Embodiment 2

[0062] The preparation method of the pharmaceutical composition of Shuangjinlian and the solution for nebulization inhalation of Shuangjinlian is as follows:

[0063] a. Decocting 45% of the mountain silver flower, 5% of the nasturtium flower, 30% of the scutellaria baicalensis and 10% of the forsythia in water by weight, decocting twice, 60 minutes each time, filtering, then combining the filtrates, and standing for 12 hours; Take the filtrate supernatant and absorb it through a pre-treated colorless and clear macroporous resin column (flow rate 5ml / min), discard the cleaning solution, and then elute with 85% ethanol. When a yellow ethanol solution flows out, start to collect The eluent is free of baicalin; after that, the ethanol is recovered and concentrated to a liquid extract (relative density 1.10, accounting for 8% of the total volume of the solution for nebulization inhalation to be prepared, (v / v)) for subsequent use;

[0064] b. Extract Bupleurum volatile oil: Put 10...

Embodiment 3

[0099] a. Add water to decoct 45% of the mountain silver flower, 5% of the nasturtium flower, 30% of the scutellaria baicalensis, and 10% of the forsythia by weight, and decoct twice for 60 minutes each time, filter, and then combine the filtrates. Concentrate under reduced pressure and concentrate into a clear paste with a specific gravity of 1.20±0.05 (50°C).

[0100] b. Stir and mix the clear ointment obtained in a with a certain amount of low-concentration ethanol, then slowly add high-concentration ethanol to make the liquid alcohol content reach 60%-80%, let it stand for more than 24 hours, filter the supernatant, and Recycling ethanol to obtain alcohol ointment

[0101] c. 10% Bupleurum bupleuri extracts volatile oil by steam distillation for 3 hours, set aside;

[0102] d. Mix the alcohol extract obtained in b and the volatile oil obtained in c, and add water to make a fixed volume mixture, and pack it into 10ml / stick or 100ml / bottle.

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Abstract

The invention discloses a Shuangjinlian pharmaceutical composition and Shuangjinlian atomization inhalation solution as well as preparation methods and application of the Shuangjinlian pharmaceutical composition and the Shuangjinlian atomization inhalation solution. The Shuangjinlian pharmaceutical composition is characterized by comprising effective component extracts of 41 to 45 parts of flos lonicerae, 5 to 9 parts of trollius chinensis, 26 to 55 parts of radix scutellariae, 5 to 19 parts of forsythia and 5 to 14 parts of bupleurum in parts by weight. Compared with the honeysuckle, the flos lonicerae used in the raw materials of the invention has an obviously prominent synergistic effect with other medicinal materials in the formula, and the prepared product has an unexpected technical effect in the treatment of upper and lower respiratory tract infection and pneumonia; compared with the conventional Shuangjinlian mixture, the atomization inhalation solution can use a special atomization inhalant dosing device to enter into lungs through respiratory tracts, thereby being small in stimulation for the respiratory tracts, easy in storage, convenient to apply, good in patient compliance, and more ideal in treatment effects.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition of Shuangjinlian, a solution for nebulized inhalation of Shuangjinlian, a preparation method and application thereof. Background technique [0002] Respiratory tract infection and pneumonia are common diseases of the respiratory system. Chinese patent: 011382457, notification number CN1150931C, relates to a Shuangjinlian oral liquid for treating colds and flu and its preparation method. Table, the effect of heat-clearing and detoxification, used for fever, pain, cough and other diseases caused by exogenous wind pathogens and colds, can be used to treat respiratory and lung infections, tonsillitis, pharyngitis, viral pneumonia and influenza, but the patent said The Shuangjinlian Oral Liquid still has some problems, for example, a large dosage and a low rate of inhibition to viral pneumonia. Contents of the invention [0003] The purpose of the present inventi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K9/72A61K9/08A61P11/00A61P31/16
CPCA61K9/0078A61K9/08A61K36/233A61K36/355A61K36/539A61K36/634A61K36/71A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 张志平郭中华刘伟伟邢泽田其木格张冰冰陈秀平谢春燕赵欢欢
Owner HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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