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Tablet containing EGCG (epigallocatechin gallate)

A technology of tablets and tablet cores, applied in the field of EGCG-containing tablets, can solve problems affecting product quality such as EGCG product development, product preparation, storage, circulation, unfavorable and hidden dangers in the use of preparations, and achieve the promotion of synergy and mutual Effect of promoting, increasing absorption rate, and improving absorption efficiency

Inactive Publication Date: 2017-10-17
杭州茗朗生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the stability of EGCG is poor, and it is easily affected by factors such as temperature, water, pH, etc., especially in a liquid environment. Its hydrolysis / degradation is serious. Even in a solid state, although the stability will be relatively improved, it is more sensitive to temperature. , will gradually degrade in a hot environment, seriously affect product quality and the development of EGCG products, have serious adverse effects on product preparation, storage, circulation, etc., and bring disadvantages and hidden dangers to the use safety of preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A kind of extracting method of above-mentioned EGCG, comprises the following steps:

[0036] (1) Remove impurities from the tea raw materials, and then clean them; then crush them in a freezer grinder, and sieve them with a mesh size of 20-50 mesh;

[0037] (2) Then dry the pulverized raw materials until the water content is below 10%;

[0038] (3) Then supercritical CO 2 Fluid extraction, and collecting the extract;

[0039] (4) Add water to the extracted tea dregs first, the amount of water added is 1L of water per kilogram of tea dregs, then boil for 10 minutes, and then carry out extraction treatment. Specifically, add water and ethanol to it, and the ratio of water and ethanol is 3 : 1, the amount of liquid added per kilogram of tea residue is 3L, and sodium citrate is added in the mixed liquid, so that the weight percentage of sodium citrate in the mixed liquid is 3%, then, the temperature is raised to 60 ° C, leached for 30min, collected Extraction solution; ...

Embodiment 2

[0043] A kind of extracting method of above-mentioned EGCG, comprises the following steps:

[0044] (1) Remove impurities from the tea raw materials, and then clean them; then crush them in a freezer grinder, and sieve them with a mesh size of 20-50 mesh;

[0045] (2) Then dry the pulverized raw materials until the water content is below 10%;

[0046] (3) Then supercritical CO 2 Fluid extraction, and collect the extract; first use microwave treatment for 20-40s, and the microwave power is 500-600W;

[0047] (4) Add water to the extracted tea dregs first, the amount of water added is 1.5L of water per kilogram of tea dregs, then boil for 30 minutes, and then carry out extraction treatment. Specifically, add water and ethanol to it. The ratio of water and ethanol is 1:1, the amount of liquid added per kilogram of tea dregs is 5L, and sodium citrate is added to the mixed liquid, so that the weight percentage of sodium citrate in the mixed liquid is 1%, then, the temperature is ...

Embodiment 3

[0051] A kind of extracting method of above-mentioned EGCG, comprises the following steps:

[0052] (1) Remove impurities from the tea raw materials, and then clean them; then crush them in a freezer grinder, and sieve them with a mesh size of 20-50 mesh;

[0053] (2) Then dry the pulverized raw materials until the moisture content is below 10%, and then carry out irradiation treatment, and the irradiation dose is 3-6kGy;

[0054] (3) After irradiation, supercritical CO 2 Fluid extraction, and collecting the extract;

[0055] (4) First add water to the extracted tea residue, the amount of water added is 1L of water per kilogram of tea residue, and then use irradiation treatment, the irradiation dose is 3kGy, then boil for 10min, and then carry out extraction treatment, specifically, continue in it Add water and ethanol, the ratio of water and ethanol is 3:1, the amount of liquid added per kilogram of tea dregs is 3L, and sodium citrate is added to the mixed liquid, so that the...

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Abstract

The present invention relates to the technical field of health products and particularly relates to a tablet containing EGCG (epigallocatechin gallate). The tablet is a compound preparation including the EGCG and quercetin or quercetin glycoside derivatives. A ratio of the EGCG to the quercetin or quercetin glycoside derivatives is (3-8):(0.3-1). In the tablet, the EGCG and quercetin or quercetin glycoside derivatives are prepared into the compound preparation. The materials are synergistically and mutually promoted, and especially, absorptions of the quercetin or quercetin glycoside derivatives are promoted. At the same time, by adding resveratrol and sorbitol in the tablet, absorption efficiencies and absorption rates of the EGCG are improved.

Description

technical field [0001] The invention relates to the technical field of health products, in particular to a tablet containing EGCG. Background technique [0002] Tea, a famous drink unique to China, is sold all over the world. Tea Polyphenols is the general term for polyphenols in tea, including flavanols, anthocyanins, flavonoids, flavonols and phenolic acids. It is mainly flavanols (catechins), and catechins account for 60-80%. Tea polyphenols, also known as tea tannin or tea tannin, are one of the main components that form the color and aroma of tea, and are also one of the main components that have health care functions in tea. [0003] Tea polyphenols are a kind of fused-ring aromatic hydrocarbons, which can be divided into flavanols, hydroxy-[4]-flavanols, anthocyanins, flavonoids, flavonols and phenolic acids. Catechin, also known as catechin and tea tannin, is a derivative of flavanol and is the most important component of tea polyphenols, accounting for about 60%-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23L33/125A23L33/10A61K31/353A61K31/352A61K31/7048A61K9/36C07D311/62A61P35/00A61P39/06A61P39/00A61P3/06
CPCA23L33/10A23L33/105A23L33/125A23V2002/00A61K9/2866A61K31/352A61K31/353A61K31/7048A23V2250/21A23V2250/214A23V2250/642A23V2200/308A23V2200/318A23V2200/30A61K2300/00Y02P20/54
Inventor 丁志
Owner 杭州茗朗生物科技有限公司
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